1. Creatinine, arsenic metabolism, and renal function in an arsenic-exposed population in Bangladesh
- Author
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Vesna Slavkovich, Pam Factor-Litvak, Mary V. Gamble, Joseph H. Graziano, Tariqul Islam, J. Richard Pilsner, Xinhua Liu, Brandilyn A. Peters, Megan N. Hall, Vesna Ilievski, Y. Dana Neugut, and Diane Levy
- Subjects
Male ,S-Adenosylmethionine ,Epidemiology ,lcsh:Medicine ,010501 environmental sciences ,01 natural sciences ,Biochemistry ,chemistry.chemical_compound ,Chronic Kidney Disease ,Medicine and Health Sciences ,Public and Occupational Health ,lcsh:Science ,2. Zero hunger ,0303 health sciences ,Bangladesh ,Molecular Epidemiology ,Multidisciplinary ,Methylation ,Middle Aged ,Chemistry ,Nephrology ,Creatinine ,Toxicity ,Physical Sciences ,Female ,Kidney Diseases ,Environmental Health ,Glomerular Filtration Rate ,Research Article ,Chemical Elements ,Adult ,medicine.medical_specialty ,Adolescent ,Urinary system ,Renal function ,Arsenic ,Excretion ,03 medical and health sciences ,Young Adult ,Internal medicine ,medicine ,Humans ,030304 developmental biology ,0105 earth and related environmental sciences ,Arsenic toxicity ,business.industry ,lcsh:R ,Biology and Life Sciences ,Environmental Exposure ,medicine.disease ,Health Care ,Endocrinology ,Cross-Sectional Studies ,chemistry ,lcsh:Q ,business ,Water Pollutants, Chemical ,Biomarkers ,Kidney disease - Abstract
Kidney disease is emerging as an arsenic (As)-linked disease outcome, however further evidence of this association is warranted. Our first objective for this paper was to examine the potential renal toxicity of As exposure in Bangladesh. Our second objective relates to examining whether the previously reported positive association between urinary creatinine (uCrn) and As methylation may be explained by renal function. We had hypothesized that these associations relate to supply and demand for s-adenosylmethionine, the methyl donor for both creatine synthesis and As methylation. Alternatively, renal function could influence both As and creatinine excretion, or the As metabolites may influence renal function, which in turn influences uCrn. We conducted a cross-sectional study (N = 478) of adults, composed of a sample recruited in 2001 and a sample recruited in 2003. We assessed renal function using plasma cystatin C, and calculated the estimated glomerular filtration rate (eGFR). Consistent with renal toxicity of As, log-uAs had a marginal inverse association with eGFR in the 2003 sample (b = -5.6, p = 0.07), however this association was not significant in the 2001 sample (b = -1.9, p = 0.24). Adjustment for eGFR did not alter the associations between uCrn and the %uAs metabolites, indicating that GFR does not explain these associations. Increased eGFR was associated with increased odds of having %uInAs >12.2% (2001: OR = 1.01, 95%CI (1.00,1.03); 2003: OR = 1.04, 95%CI (1.01,1.07)). In the 2003 sample only, there was a negative association between eGFR and %uDMA (b = -0.08, p = 0.02). These results may indicate differential effects of renal function on excretion of InAs and DMA. Alternatively, a certain methylation pattern, involving decreased %InAs and increased %DMA, may reduce renal function. Given that these studies were cross-sectional, we cannot distinguish between these two possibilities. Discrepancies between the samples may be due to the higher As exposure, poorer nutrition, and lower As methylation capacity in the 2003 sample.
- Published
- 2014