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1. Prognostic Impact of CT-Quantified Muscle and Fat Distribution before and after First-Line-Chemotherapy in Lung Cancer Patients.

Author

Johanna Nattenmüller, Raoul Wochner, Thomas Muley, Martin Steins, Simone Hummler, Birgit Teucher, Joachim Wiskemann, Hans-Ulrich Kauczor, Mark Oliver Wielpütz, and Claus Peter Heussel

Subjects
Medicine, Science
Abstract

Cachexia and sarcopenia are associated with poor outcome and increased chemotherapy-induced toxicity in lung cancer patients. However, the complex interplay of obesity, sarcopenia and cachexia, and its impact on survival in the context of first-line-chemotherapy is not yet understood.In 200 consecutively recruited lung cancer patients (70 female, mean age 62y; mean BMI 25 kg/m2; median follow-up 15.97 months) with routine staging-CT before and after chemotherapy (CTX, mean interval: 4.3 months), densitometric quantification of total (TFA), visceral (VFA), and subcutaneous-fat-area (SFA), inter-muscular-fat-area (IMFA), muscle-density (MD), muscle-area (MA) and skeletal-muscle-index (SMI) was performed retrospectively to evaluate changes under chemotherapy and the impact on survival.We observed increases in TFA, VFA, SFA, VFA/SFA, and IMFA (p

Published
2017
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2. CT characteristics in pulmonary adenocarcinoma with epidermal growth factor receptor mutation.

Author

Jing Zhao, Julien Dinkel, Arne Warth, Roland Penzel, Niels Reinmuth, Philipp Schnabel, Thomas Muley, Michael Meister, Heike Zabeck, Martin Steins, Jian-Yong Yang, Qian Zhou, Heinz-Peter Schlemmer, Felix J F Herth, Hans-Ulrich Kauczor, and Claus Peter Heussel

Subjects
Medicine, Science
Abstract

Comprehensively investigate the association of CT morphology and clinical findings of adenocarcinoma with EGFR mutation status. Retrospectively included 282 patients who was pathologically proved as lung adenocarcinoma with known EGFR mutation status (mutations: 138 patients, female: 86, median age: 66 years; wildtype: 144 patients, female: 67, median age: 62 years) and their pre-treatment CT scans were analyzed. CT findings and clinical information were collected. Univariate and multivariable logistic regression analysis were performed. Adjusted for age, gender and smoking history of two groups, significantly more patients with pleural tags, pleural and liver metastases were found in the EGFR mutated group (P = 0.007, 0.004, and 0.043, respectively). Multivariable logistic regression analysis found that the model included age, gender, smoking history, air bronchogram, pleural tags, pleural and liver metastasis had a moderate predictive value for EGFR mutation status (AUC = 0.741, P < .0001). Exon-19 deletion was associated with air bronchogram which adjusted for age, gender and smoking history (P = 0.007, OR: 2.91, 95%CI: 1.25-7.79). The evidence of pleural tags, pleural and liver metastases go along with a higher probability of EGFR mutation in adenocarcinoma patients and air bronchogram is positively associated with Exon-19 deletion mutation.

Published
2017
Full Text
View/download PDF

3. CT characteristics in pulmonary adenocarcinoma with epidermal growth factor receptor mutation

Author

Jing Zhao, Julien Dinkel, Arne Warth, Roland Penzel, Niels Reinmuth, Philipp Schnabel, Thomas Muley, Michael Meister, Heike Zabeck, Martin Steins, Jian-Yong Yang, Qian Zhou, Heinz-Peter Schlemmer, Felix J F Herth, Hans-Ulrich Kauczor, and Claus Peter Heussel

Subjects
Adult, Male, Lung Neoplasms, Imaging Techniques, lcsh:Medicine, Neuroimaging, Adenocarcinoma, Research and Analysis Methods, Carcinomas, Diagnostic Radiology, Metastasis, Mathematical and Statistical Techniques, Diagnostic Medicine, Adenocarcinomas, Basic Cancer Research, Genetics, Medicine and Health Sciences, Humans, Point Mutation, Statistical Methods, lcsh:Science, Tomography, Aged, Aged, 80 and over, Insertion Mutation, Radiology and Imaging, lcsh:R, Biology and Life Sciences, Cancers and Neoplasms, Middle Aged, Thorax, Computed Axial Tomography, ErbB Receptors, Deletion Mutation, Oncology, Mutation, Physical Sciences, Pleurae, Regression Analysis, lcsh:Q, Female, Anatomy, Tomography, X-Ray Computed, Mathematics, Statistics (Mathematics), Research Article, Neuroscience
Abstract

Comprehensively investigate the association of CT morphology and clinical findings of adenocarcinoma with EGFR mutation status. Retrospectively included 282 patients who was pathologically proved as lung adenocarcinoma with known EGFR mutation status (mutations: 138 patients, female: 86, median age: 66 years; wildtype: 144 patients, female: 67, median age: 62 years) and their pre-treatment CT scans were analyzed. CT findings and clinical information were collected. Univariate and multivariable logistic regression analysis were performed. Adjusted for age, gender and smoking history of two groups, significantly more patients with pleural tags, pleural and liver metastases were found in the EGFR mutated group (P = 0.007, 0.004, and 0.043, respectively). Multivariable logistic regression analysis found that the model included age, gender, smoking history, air bronchogram, pleural tags, pleural and liver metastasis had a moderate predictive value for EGFR mutation status (AUC = 0.741, P < .0001). Exon-19 deletion was associated with air bronchogram which adjusted for age, gender and smoking history (P = 0.007, OR: 2.91, 95%CI: 1.25-7.79). The evidence of pleural tags, pleural and liver metastases go along with a higher probability of EGFR mutation in adenocarcinoma patients and air bronchogram is positively associated with Exon-19 deletion mutation.

Published
2016

4. Prognostic Impact of CT-Quantified Muscle and Fat Distribution before and after First-Line-Chemotherapy in Lung Cancer Patients

Author

Johanna Nattenmüller, Raoul Wochner, Thomas Muley, Martin Steins, Simone Hummler, Birgit Teucher, Joachim Wiskemann, Hans-Ulrich Kauczor, Mark Oliver Wielpütz, and Claus Peter Heussel

Subjects
Male, Clinical Oncology, Sarcopenia, Lung Neoplasms, Physiology, Muscle Tissue, Cancer Treatment, lcsh:Medicine, Antineoplastic Agents, Pathology and Laboratory Medicine, Biochemistry, Lung and Intrathoracic Tumors, Fats, Cancer Chemotherapy, Signs and Symptoms, Drug Therapy, Diagnostic Medicine, Medicine and Health Sciences, Humans, Chemotherapy, Obesity, lcsh:Science, Muscle, Skeletal, Aged, Retrospective Studies, Pharmaceutics, lcsh:R, Body Weight, Biology and Life Sciences, Cancers and Neoplasms, Middle Aged, Prognosis, Survival Analysis, Lipids, Biological Tissue, Adipose Tissue, Oncology, Physiological Parameters, Body Composition, lcsh:Q, Female, Anatomy, Clinical Medicine, Research Article
Abstract

Introduction Cachexia and sarcopenia are associated with poor outcome and increased chemotherapy-induced toxicity in lung cancer patients. However, the complex interplay of obesity, sarcopenia and cachexia, and its impact on survival in the context of first-line-chemotherapy is not yet understood. Methods In 200 consecutively recruited lung cancer patients (70 female, mean age 62y; mean BMI 25 kg/m2; median follow-up 15.97 months) with routine staging-CT before and after chemotherapy (CTX, mean interval: 4.3 months), densitometric quantification of total (TFA), visceral (VFA), and subcutaneous-fat-area (SFA), inter-muscular-fat-area (IMFA), muscle-density (MD), muscle-area (MA) and skeletal-muscle-index (SMI) was performed retrospectively to evaluate changes under chemotherapy and the impact on survival. Results We observed increases in TFA, VFA, SFA, VFA/SFA, and IMFA (p

Published
2016

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