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1. Persistent left ventricular dysfunction after acute lymphocytic myocarditis: Frequency and predictors.

Author

Marco Merlo, Enrico Ammirati, Piero Gentile, Jessica Artico, Antonio Cannatà, Gherardo Finocchiaro, Giulia Barbati, Paola Sormani, Marisa Varrenti, Andrea Perkan, Enrico Fabris, Aneta Aleksova, Rossana Bussani, Duccio Petrella, Manlio Cipriani, Claudia Raineri, Maria Frigerio, and Gianfranco Sinagra

Subjects
Medicine, Science
Abstract

BACKGROUND:Persistent left ventricular (LV) systolic dysfunction in patients with acute lymphocytic myocarditis (LM) is widely unexplored. OBJECTIVES:To assess the frequency and predictors of persistent LV dysfunction in patients with LM and reduced LVEF at admission. METHODS AND RESULTS:We retrospectively evaluated 89 consecutive patients with histologically-proven acute myocarditis enrolled at three Italian referral hospitals. A subgroup of 48 patients with LM, baseline systolic impairment and an available echocardiographic assessment at 12 months (6-18) from discharge constituted the study population. The primary study end-point was persistent LV dysfunction, defined as LVEF

Published
2019
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2. Persistent left ventricular dysfunction after acute lymphocytic myocarditis: Frequency and predictors

Author

Enrico Fabris, Enrico Ammirati, Antonio Cannatà, Paola Sormani, Gianfranco Sinagra, Marco Merlo, Piero Gentile, Manlio Cipriani, Andrea Perkan, Duccio Petrella, Claudia Raineri, Maria Frigerio, Giulia Barbati, Marisa Varrenti, Gherardo Finocchiaro, Rossana Bussani, Aneta Aleksova, Jessica Artico, Merlo, M., Ammirati, E., Gentile, P., Artico, J., Cannata, A., Finocchiaro, G., Barbati, G., Sormani, P., Varrenti, M., Perkan, A., Fabris, E., Aleksova, A., Bussani, R., Petrella, D., Cipriani, M., Raineri, C., Frigerio, M., Sinagra, G., Merlo, M, Ammirati, E, Gentile, P, Artico, J, Cannata, A, Finocchiaro, G, Barbati, G, Sormani, P, Varrenti, M, Perkan, A, Fabris, E, Aleksova, A, Bussani, R, Petrella, D, Cipriani, M, Raineri, C, Frigerio, M, and Sinagra, G

Subjects
Male, Biopsy, 030204 cardiovascular system & hematology, Pathology and Laboratory Medicine, Ventricular Dysfunction, Left, 0302 clinical medicine, Medicine and Health Sciences, Group-Specific Staining, Medicine, Lymphocytes, 030212 general & internal medicine, Immune Response, Staining, left ventricular dysfunction, Multidisciplinary, Ejection fraction, Area under the curve, Drugs, Stroke volume, Prognosis, Immunosuppressives, Acute Disease, Cardiology, Female, Anatomy, Research Article, Adult, medicine.medical_specialty, Histology, Myocarditis, lymphocytic myocarditis, Systole, Science, Immunology, Surgical and Invasive Medical Procedures, Research and Analysis Methods, Necrosis, 03 medical and health sciences, Signs and Symptoms, Diagnostic Medicine, Internal medicine, Humans, Retrospective Studies, Inflammation, Pharmacology, business.industry, Hematoxylin Staining, Biology and Life Sciences, Stroke Volume, Retrospective cohort study, Odds ratio, medicine.disease, Confidence interval, myocarditis, Specimen Preparation and Treatment, myocarditi, business, Ejection Fraction
Abstract

Background Persistent left ventricular (LV) systolic dysfunction in patients with acute lymphocytic myocarditis (LM) is widely unexplored. Objectives To assess the frequency and predictors of persistent LV dysfunction in patients with LM and reduced LVEF at admission. Methods and results We retrospectively evaluated 89 consecutive patients with histologically-proven acute myocarditis enrolled at three Italian referral hospitals. A subgroup of 48 patients with LM, baseline systolic impairment and an available echocardiographic assessment at 12 months (6–18) from discharge constituted the study population. The primary study end-point was persistent LV dysfunction, defined as LVEF

Published
2019
Full Text
View/download PDF

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