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14 results on '"Levi, José Eduardo"'

1. Presence of HPV with overexpression of p16INK4a protein and EBV infection in penile cancer—A series of cases from Brazil Amazon

Author

Martins, Valquíria do Carmo Alves, primary, Cunha, Isabela Werneck, additional, Figliuolo, Giuseppe, additional, Rondon, Heidy Halanna de Melo Farah, additional, de Souza, Paloma Menezes, additional, Torres Silva, Felipe Luz, additional, Torres Silva, Guilherme Luz, additional, de Souza Bastos, Michele, additional, de Castro, Daniel Barros, additional, Santana, Monique Freire, additional, Ramasawmy, Rajendranath, additional, Levi, José Eduardo, additional, and Torres, Kátia Luz, additional

Published
2020
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2. Human Papillomavirus (HPV) seroprevalence, cervical HPV prevalence, genotype distribution and cytological lesions in solid organ transplant recipients and immunocompetent women in Sao Paulo, Brazil.

Author

Miyaji, Karina Takesaki, Infante, Vanessa, Picone, Camila de Melo, Levi, José Eduardo, Oliveira, Ana Carolina Soares de, Lara, Amanda Nazareth, Tacla, Maricy, Dillner, Joakim, Kann, Hanna, Eklund, Carina, Castanheira, Cristina Paula, Mayaud, Philippe, and Sartori, Ana Marli Christovam

Subjects
PAPILLOMAVIRUS diseases, TRANSPLANTATION of organs, tissues, etc., PAPILLOMAVIRUSES, SEROPREVALENCE, POLYMERASE chain reaction, SEXUAL intercourse
Abstract

Introduction: Solid organ transplant (SOT) recipients are at increased risk of Human Papillomavirus (HPV) persistent infection and disease. This study aimed to evaluate HPV seroprevalence, cervical HPV prevalence, genotype distribution, and frequency of HPV-related cervical lesions in SOT recipients in comparison to immunocompetent women. Methods: Cross-sectional study including SOT and immunocompetent women aged 18 to 45 years who denied previous HPV-related lesions. Cervical samples were screened for HPV-DNA by a polymerase chain reaction (PCR)-based DNA microarray system (PapilloCheck®) and squamous intraepithelial lesions (SIL) by liquid-based cytology. A multiplexed pseudovirion-based serology assay (PsV-Luminex) was used to measure HPV serum antibodies. Results: 125 SOT and 132 immunocompetent women were enrolled. Cervical samples were collected from 113 SOT and 127 immunocompetent women who had initiated sexual activity. HPV-DNA prevalence was higher in SOT than in immunocompetent women (29.6% vs. 20.2%, p = 0.112), but this difference was not statistically significant. High-risk (HR)-HPV was significantly more frequent in SOT than in immunocompetent women (19.4% vs. 7.9%, p = 0.014). Simultaneous infection with ≥2 HR-HPV types was found in 3.1% of SOT and 0.9% of immunocompetent women. HPV seropositivity for at least one HPV type was high in both groups: 63.8% of 105 SOT and 69.7% of 119 immunocompetent women (p = 0.524). Low-grade (LSIL) and high-grade SIL (HSIL) were significantly more frequent in SOT (9.7% and 5.3%, respectively) than in immunocompetent women (1.6% and 0.8%, respectively) (p = 0.001). Conclusions: These results may reflect the increased risk of HPV persistent infection and disease progression in SOT women due to chronic immunosuppression. [ABSTRACT FROM AUTHOR]

Published
2022
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3. Modulated Zika virus NS1 conjugate offers advantages for accurate detection of Zika virus specific antibody in double antigen binding and Ig capture enzyme immunoassays

Author

Tedder, Richard S., primary, Dicks, Steve, additional, Ijaz, Samreen, additional, Santiago de Souza, Nathalia Caroline, additional, Vincente de Paula, Anderson, additional, Levy, Flavia, additional, Medialdea-Carrera, Raquel, additional, Levi, José Eduardo, additional, Pannuti, Claudio S., additional, Carvalho de Sequeira, Patrícia, additional, Brown, David W. G., additional, and Ushiro Lumb, Ines, additional

Published
2019
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4. Presence of HPV with overexpression of p16INK4a protein and EBV infection in penile cancer—A series of cases from Brazil Amazon.

Author

Martins, Valquíria do Carmo Alves, Cunha, Isabela Werneck, Figliuolo, Giuseppe, Rondon, Heidy Halanna de Melo Farah, de Souza, Paloma Menezes, Torres Silva, Felipe Luz, Torres Silva, Guilherme Luz, de Souza Bastos, Michele, de Castro, Daniel Barros, Santana, Monique Freire, Ramasawmy, Rajendranath, Levi, José Eduardo, and Torres, Kátia Luz

Subjects
PENILE cancer, PENILE prostheses, PAPILLOMAVIRUSES, BIOMARKERS, INFECTION, CANCER hospitals
Abstract

Background: In Brazil, penile cancer (PC) is not uncommon. The highest incidence of PC is in the North and Northeast of the country. In addition to phimosis, the Human Papillomavirus (HPV) and Epstein-Baar Virus (EBV) infections are also related as risk factors for PC. The overexpression of p16INK4a is a surrogate sensitive marker of HPV infection in PC. Objectives: To correlate p16INK4a overexpression and HPV infection status with EBV infection in a series of PC patients from the Amazon region. Methods: Tumor tissues from 47 PC cases were analyzed for the presence of HPV and EBV DNA by PCR. All PC patients were diagnosed between 2013 and 2018 at a public reference cancer center hospital in Manaus, Amazonas—Brazil. HPV was genotyped using E7 HPV16/HPV18 type-specific real-time PCR and the PapilloCheck® HPV-Screening assay. p16INK4a expression was evaluated by immunohistochemistry using the automated Ventana® BenchMark Ultra. Results: The mean age of patients at the time of diagnosis was 57.4 years ±SD 17.8 ranging from 20 to 90 years old. Most of the patients (64%) came from rural areas of the Amazonas State. Thirty patients had phimosis (64%). Among the patients with phimosis, 43% (13/30) underwent circumcision, three during childhood and 10 in adulthood. 60% of the patients were smokers or ex-smokers. HPV infection was observed in 45% (21/47) of cases. HPV16 was detected in 13 patients (61%). Other HPV types detected were HPV 6, 11, 42, 51, 53, 68 and 44/55. EBV infection was observed in 30% (14/47) of the patients with PC. Co-infection with HPV and EBV was observed in 28% (6/21) cases. p16INK4a was only investigated in 26 samples. The p16INK4a overexpression was observed exclusively in HPV 16 positive cases and four HPV negative cases. In the survival analysis, the follow-up time was 35.4 months/patient. The mortality rate during the follow up time was 38%. Conclusions: p16INK4a positivity presented a high correlation to HPV 16 DNA detection, reinforcing its use as a surrogate marker for HPV-driven cancers. Infection with EBV was quite frequent and its role in epithelial penile oncogenesis needs to be demonstrated. [ABSTRACT FROM AUTHOR]

Published
2020
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5. Self-sampling coupled to the detection of HPV 16 and 18 E6 protein: A promising option for detection of cervical malignancies in remote areas

Author

Torres, Kátia Luz, primary, Mariño, Josiane Montanho, additional, Pires Rocha, Danielle Albuquerque, additional, de Mello, Mônica Bandeira, additional, de Melo Farah, Heydy Halanna, additional, Reis, Renato dos Santos, additional, Alves, Valquíria do Carmo Rodrigues, additional, Gomes, Edson, additional, Martins, Toni Ricardo, additional, Soares, Ana Carolina, additional, de Oliveira, Cristina Mendes, additional, and Levi, José Eduardo, additional

Published
2018
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6. Genomic analysis of head and neck cancer cases from two high incidence regions

Author

Perdomo, Sandra, primary, Anantharaman, Devasena, additional, Foll, Matthieu, additional, Abedi-Ardekani, Behnoush, additional, Durand, Geoffroy, additional, Reis Rosa, Luciana Albina, additional, Holmila, Reetta, additional, Le Calvez-Kelm, Florence, additional, Tajara, Eloiza H., additional, Wünsch-Filho, Victor, additional, Levi, José Eduardo, additional, Vilensky, Marta, additional, Polesel, Jerry, additional, Holcatova, Ivana, additional, Simonato, Lorenzo, additional, Canova, Cristina, additional, Lagiou, Pagona, additional, McKay, James D., additional, and Brennan, Paul, additional

Published
2018
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8. A Low-Cost HPV Immunochromatographic Assay to Detect High-Grade Cervical Intraepithelial Neoplasia

Author

Mariano, Vânia Sammartino, primary, Lorenzi, Adriana Tarlá, additional, Scapulatempo-Neto, Cristovam, additional, Stein, Maíra Degiovani, additional, Resende, Julio Cesar Possati, additional, Antoniazzi, Márcio, additional, Villa, Luisa Lina, additional, Levi, José Eduardo, additional, Longatto-Filho, Adhemar, additional, and Fregnani, José Humberto Tavares Guerreiro, additional

Published
2016
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9. Inter- and Intra-Host Viral Diversity in a Large Seasonal DENV2 Outbreak

Author

Romano, Camila Malta, primary, Lauck, Michael, additional, Salvador, Felipe S., additional, Lima, Célia Rodrigues, additional, Villas-Boas, Lucy S., additional, Araújo, Evaldo Stanislau A., additional, Levi, José Eduardo, additional, Pannuti, Claudio Sergio, additional, O’Connor, David, additional, and Kallas, Esper Georges, additional

Published
2013
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13. Factors Associated with Colposcopy-Histopathology Confirmed Cervical Intraepithelial Neoplasia among HIV-Infected Women from Rio De Janeiro, Brazil

Author

de Andrade, Angela Cristina Vasconcelos, primary, Luz, Paula Mendes, additional, Velasque, Luciane, additional, Veloso, Valdiléa Gonçalves, additional, Moreira, Ronaldo I., additional, Russomano, Fabio, additional, Chicarino-Coelho, Janice, additional, Pires, Elaine, additional, Levi, José Eduardo, additional, Grinsztejn, Beatriz, additional, and Friedman, Ruth Khalili, additional

Published
2011
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14. Characterization of Dengue Virus Type 2: New Insights on the 2010 Brazilian Epidemic

Author

Romano, Camila Malta, primary, de Matos, Andréia Manso, additional, Araújo, Evaldo Stanislau A., additional, Villas-Boas, Lucy Santos, additional, da Silva, Wanessa Cardoso, additional, Oliveira, Olímpia M. N. P. F., additional, Carvalho, Karina I., additional, de Souza, Ana Carolina Mamana, additional, Rodrigues, Celia L., additional, Levi, José Eduardo, additional, Kallas, Esper G., additional, and Pannuti, Claudio Sergio, additional

Published
2010
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