1. The TP73 gene polymorphism (rs4648551, A>G) is associated with diminished ovarian reserve.
- Author
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Laura Diniz Vagnini, Adriana Renzi, Gabriela Ravanelli Oliveira-Pelegrin, Maria do Carmo Tomitão Canas, Claudia Guilhermino Petersen, Ana Lucia Mauri, João Batista Alcantara Oliveira, Ricardo Luiz Razera Baruffi, Mario Cavagna, and José Gonçalves Franco Junior
- Subjects
Medicine ,Science - Abstract
It's known that the members of the TP53 family are involved in the regulation of female reproduction. Studies in mice showed that the TP73 gene (member of this family) plays a role in the size of follicular pool, ovulation rate and maintenance of genomic stability. In the present study we analyzed data from 605 patients with ≤ 37 years attending their first intracytoplasmic sperm injection (ICSI). The association between the TP73 polymorphism (rs4648551, A>G) and the following parameters related to ovarian reserve, like age, antral follicular count (AFC), anti-Mullerian hormone levels (AMH) and ovarian response prediction index (ORPI) was evaluated. Our results showed an association of the AA genotype with diminished ovarian reserve (AMH
- Published
- 2015
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