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3 results on '"Lam Van Nguyen"'

1. The changing characteristics of a cohort of children and adolescents living with HIV at antiretroviral therapy initiation in Asia.

Author

Johanna Beulah Sornillo, Rossana Ditangco, Aarti Kinikar, Dewi Kumara Wati, Quy Tuan Du, Dinh Qui Nguyen, Vohith Khol, Lam Van Nguyen, Thanyawee Puthanakit, Pradthana Ounchanum, Nia Kurniati, Kulkanya Chokephaibulkit, Thahira A Jamal Mohamed, Tavitiya Sudjaritruk, Siew Moy Fong, Nagalingeswaran Kumarasamy, Pope Kosalaraksa, Revathy A Nallusamy, Nik Khairulddin Nik Yusoff, Annette H Sohn, Azar Kariminia, and TREAT Asia Pediatric HIV Observational Database of IeDEA Asia-Pacific

Subjects
Medicine, Science
Abstract

Despite improvements in HIV testing and earlier antiretroviral therapy (ART) initiation in children living with HIV through the years, a considerable proportion start treatment with advanced disease. We studied characteristics of children and adolescents living with HIV and their level of immunodeficiency at ART initiation using data from a multi-country Asian cohort. We included children and adolescents who were ART-naïve and

Published
2023
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2. Alterations in children's sub-dominant gut microbiota by HIV infection and anti-retroviral therapy.

Author

Quynh Thi Nguyen, Azumi Ishizaki, Xiuqiong Bi, Kazunori Matsuda, Lam Van Nguyen, Hung Viet Pham, Chung Thi Thu Phan, Thuy Thi Bich Phung, Tuyen Thi Thu Ngo, An Van Nguyen, Dung Thi Khanh Khu, and Hiroshi Ichimura

Subjects
Medicine, Science
Abstract

ObjectiveWe investigated the impact of human immunodeficiency virus (HIV) infection and anti-retroviral therapy (ART) on the gut microbiota of children.DesignThis cross-sectional study investigated the gut microbiota of children with and without HIV.MethodsWe collected fecal samples from 59 children with HIV (29 treated with ART [ART(+)] and 30 without ART [HIV(+)]) and 20 children without HIV [HIV(-)] in Vietnam. We performed quantitative RT-PCR to detect 14 representative intestinal bacteria targeting 16S/23S rRNA molecules. We also collected the blood samples for immunological analyses.ResultsIn spearman's correlation analyses, no significant correlation between the number of dominant bacteria and age was found among children in the HIV(-) group. However, the number of sub-dominant bacteria, including Streptococcus, Enterococcus, and Enterobacteriaceae, positively correlated with age in the HIV(-) group, but not in the HIV(+) group. In the HIV(+) group, Clostridium coccoides group positively associated with the CD4+ cell count and its subsets. In the ART(+) group, Staphylococcus and C. perfringens positively correlated with CD4+ cells and their subsets and negatively with activated CD8+ cells. C. coccoides group and Bacteroides fragilis group were associated with regulatory T-cell counts. In multiple linear regression analyses, ART duration was independently associated with the number of C. perfringens, and Th17 cell count with the number of Staphylococcus in the ART(+) group.ConclusionsHIV infection and ART may influence sub-dominant gut bacteria, directly or indirectly, in association with immune status in children with HIV.

Published
2021
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3. Alterations in children’s sub-dominant gut microbiota by HIV infection and anti-retroviral therapy

Author

Azumi Ishizaki, Quynh Thi Nguyen, Dung Thi Khanh Khu, An Van Nguyen, Chung Thi Thu Phan, Hung Viet Pham, Lam Van Nguyen, Thuy Thi Bich Phung, Xiuqiong Bi, Kazunori Matsuda, Hiroshi Ichimura, and Tuyen Thi Thu Ngo

Subjects
Male, RNA viruses, Staphylococcus, HIV Infections, Gut flora, Pathology and Laboratory Medicine, medicine.disease_cause, Clostridium Perfringens, Mathematical and Statistical Techniques, Immunodeficiency Viruses, Antiretroviral Therapy, Highly Active, Lactobacillus, Medicine and Health Sciences, Public and Occupational Health, Child, Principal Component Analysis, Multidisciplinary, biology, Streptococcus, Statistics, Age Factors, virus diseases, Vaccination and Immunization, Enterobacteriaceae, Bacterial Pathogens, Medical Microbiology, Child, Preschool, Viral Pathogens, Viruses, Physical Sciences, Medicine, Infectious diseases, Regression Analysis, Female, Pathogens, Bacteroides fragilis, Research Article, Medical conditions, Science, Immunology, Antiretroviral Therapy, Viral diseases, Linear Regression Analysis, Research and Analysis Methods, Microbiology, Antiviral Therapy, Trimethoprim, Sulfamethoxazole Drug Combination, Retroviruses, medicine, Humans, Statistical Methods, Microbial Pathogens, Feces, Bacteria, business.industry, Gut Bacteria, Lentivirus, Organisms, Biology and Life Sciences, HIV, biology.organism_classification, Gastrointestinal Microbiome, Linear Models, Preventive Medicine, business, Mathematics, CD8
Abstract

Objective We investigated the impact of human immunodeficiency virus (HIV) infection and anti-retroviral therapy (ART) on the gut microbiota of children. Design This cross-sectional study investigated the gut microbiota of children with and without HIV. Methods We collected fecal samples from 59 children with HIV (29 treated with ART [ART(+)] and 30 without ART [HIV(+)]) and 20 children without HIV [HIV(–)] in Vietnam. We performed quantitative RT-PCR to detect 14 representative intestinal bacteria targeting 16S/23S rRNA molecules. We also collected the blood samples for immunological analyses. Results In spearman’s correlation analyses, no significant correlation between the number of dominant bacteria and age was found among children in the HIV(−) group. However, the number of sub-dominant bacteria, including Streptococcus, Enterococcus, and Enterobacteriaceae, positively correlated with age in the HIV(−) group, but not in the HIV(+) group. In the HIV(+) group, Clostridium coccoides group positively associated with the CD4+ cell count and its subsets. In the ART(+) group, Staphylococcus and C. perfringens positively correlated with CD4+ cells and their subsets and negatively with activated CD8+ cells. C. coccoides group and Bacteroides fragilis group were associated with regulatory T-cell counts. In multiple linear regression analyses, ART duration was independently associated with the number of C. perfringens, and Th17 cell count with the number of Staphylococcus in the ART(+) group. Conclusions HIV infection and ART may influence sub-dominant gut bacteria, directly or indirectly, in association with immune status in children with HIV.

Published
2021

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