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Your search keyword '"Kumar, Nathella Pavan"' showing total 11 results
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11 results on '"Kumar, Nathella Pavan"'

1. BCG vaccination induces enhanced frequencies of memory T cells and altered plasma levels of common γc cytokines in elderly individuals

Author

Kumar, Nathella Pavan, primary, Padmapriyadarsini, Chandrasekaran, additional, Rajamanickam, Anuradha, additional, Bhavani, Perumal Kannabiran, additional, Nancy, Arul, additional, Jayadeepa, Bharathi, additional, Selvaraj, Nandhini, additional, Asokan, Dinesh, additional, Renji, Rachel Mariam, additional, Venkataramani, Vijayalakshmi, additional, Tripathy, Srikanth, additional, and Babu, Subash, additional

Published
2021
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11. Decreased Frequencies of Circulating CD4+ T Follicular Helper Cells Associated with Diminished Plasma IL-21 in Active Pulmonary Tuberculosis.

Author

Kumar, Nathella Pavan, Sridhar, Rathinam, Hanna, Luke E., Banurekha, Vaithilingam V., Nutman, Thomas B., and Babu, Subash

Subjects
*T helper cells, *TH1 cells, *LYMPHOCYTES, *CYTOPROTECTION, *CYTOLOGY, *TUBERCULOSIS
Abstract

Background: Circulating T follicular helper (Tfh) cells represent a distinct subset of CD4+ T cells and are important in immunity to infections. Although they have been shown to play a role in experimental models of tuberculosis infection, their role in human tuberculosis remains unexplored. Aims/Methodology: To determine the distribution of circulating Tfh cells in human TB, we measured the frequencies of Tfh cells ex vivo and following TB - antigen or polyclonal stimulation in pulmonary TB (PTB; n = 30) and latent TB (LTB; n = 20) individuals, using the markers CXCR5, PD-1 and ICOS. Results: We found that both ex vivo and TB - antigen induced frequencies of Tfh cell subsets was significantly lower in PTB compared to LTB individuals. Similarly, antigen induced frequencies of Tfh cells expressing IL-21 was also significantly lower in PTB individuals and this was reflected in diminished circulating levels of IL-21 and IFNγ. This was not accompanied by diminished frequencies of activated or memory B cell subsets. Finally, the diminution in frequency of Tfh cells in PTB individuals was dependent on IL-10, CTLA-4 and PD-L1 in vitro. Conclusions: Thus, PTB is characterized by adiminution in the frequency of Tfh cell subsets. [ABSTRACT FROM AUTHOR]

Published
2014
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