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Your search keyword '"Krueger, James G."' showing total 17 results
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17 results on '"Krueger, James G."'

4. A Randomized, Placebo-Controlled Study of SRT2104, a SIRT1 Activator, in Patients with Moderate to Severe Psoriasis

Author

Krueger, James G., primary, Suárez-Fariñas, Mayte, additional, Cueto, Inna, additional, Khacherian, Artemis, additional, Matheson, Robert, additional, Parish, Lawrence C., additional, Leonardi, Craig, additional, Shortino, Denise, additional, Gupta, Akanksha, additional, Haddad, Jonathan, additional, Vlasuk, George P., additional, and Jacobson, Eric W., additional

Published
2015
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7. IL-17 Induces an Expanded Range of Downstream Genes in Reconstituted Human Epidermis Model

Author

Chiricozzi, Andrea, primary, Nograles, Kristine E., additional, Johnson-Huang, Leanne M., additional, Fuentes-Duculan, Judilyn, additional, Cardinale, Irma, additional, Bonifacio, Kathleen M., additional, Gulati, Nicholas, additional, Mitsui, Hiroshi, additional, Guttman-Yassky, Emma, additional, Suárez-Fariñas, Mayte, additional, and Krueger, James G., additional

Published
2014
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10. Increased Tc22 and Treg/CD8 Ratio Contribute to Aggressive Growth of Transplant Associated Squamous Cell Carcinoma

Author

Zhang, Shali, primary, Fujita, Hideki, additional, Mitsui, Hiroshi, additional, Yanofsky, Valerie R., additional, Fuentes-Duculan, Judilyn, additional, Pettersen, Julia S., additional, Suárez-Fariñas, Mayte, additional, Gonzalez, Juana, additional, Wang, Claire Q. F., additional, Krueger, James G., additional, Felsen, Diane, additional, and Carucci, John A., additional

Published
2013
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13. Post-Therapeutic Relapse of Psoriasis after CD11a Blockade Is Associated with T Cells and Inflammatory Myeloid DCs

Author

Johnson-Huang, Leanne M., primary, Pensabene, Cara A., additional, Shah, Kejal R., additional, Pierson, Katherine C., additional, Kikuchi, Toyoko, additional, Lentini, Tim, additional, Gilleaudeau, Patricia, additional, Sullivan-Whalen, Mary, additional, Cueto, Inna, additional, Khatcherian, Artemis, additional, Hyder, Luke A., additional, Suárez-Fariñas, Mayte, additional, Krueger, James G., additional, and Lowes, Michelle A., additional

Published
2012
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16. Meta-Analysis Derived (MAD) Transcriptome of Psoriasis Defines the "Core" Pathogenesis of Disease.

Author

Suyan Tian, Krueger, James G., Li, Katherine, Jabbari, Ali, Brodmerkel, Carrie, Lowes, Michelle A., Suárez-Fariñas, Mayte, and Soyer, H. Peter

Subjects
*GENETIC transcription, *PSORIASIS & genetics, *SKIN inflammation, *GENE expression, *MEDICAL genetics, *GENES, *GENETICS
Abstract

The cause of psoriasis, a common chronic inflammatory skin disease, is not fully understood. Microarray experiments have been widely used in recent years to identify genes associated with psoriasis pathology, by comparing expression levels of lesional (LS) with adjacent non-lesional (NL) skin. It is commonly observed that the differentially expressed genes (DEGs) differ greatly across experiments, due to variations introduced in the microarray experiment pipeline. Therefore, a statistically based meta-analytic approach, which combines the results of individual studies, is warranted. In this study, a meta-analysis was conducted on 5 microarray data sets, including 193 LS and NL pairs. We termed this the Meta-Analysis Derived (MAD) transcriptome. In "MAD-5'' transcriptome, 677 genes were up-regulated and 443 were down-regulated in LS skin compared to NL skin. This represents a much larger set than the intersection of DEGs of these 5 studies, which consisted of 100 DEGs. We also analyzed 3 of the studies conducted on the Affymetrix hgu133plus2 chips and found a greater number of DEGs (1084 up- and 748 down-regulated). Top canonical pathways over-represented in the MAD transcriptome include Atherosclerosis Signaling and Fatty Acid Metabolism, while several ''new'' genes identified are involved in Cardiovascular Development and Lipid Metabolism. These findings highlight the relationship between psoriasis and systemic manifestations such as the metabolic syndrome and cardiovascular disease. Then, the Meta Threshold Gradient Descent Regularization (MTGDR) algorithm was used to select potential markers distinguishing LS and NL skin. The resulting set (20 genes) contained many genes that were part of the residual disease genomic profile (RDGP) or ''molecular scar''after successful treatment, and also genes subject to differential methylation in LS tissues. To conclude, this MAD transcriptome yielded a reference list of reliable psoriasis DEGs, and represents a robust pool of candidates for further discovery of pathogenesis and treatment evaluation. [ABSTRACT FROM AUTHOR]

Published
2012
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17. Clinical Symptoms of Skin, Nails, and Joints Manifest Independently in Patients with Concomitant Psoriasis and Psoriatic Arthritis.

Author

Wittkowski, Knut M., Leonardi, Craig, Gottlieb, Alice, Menter, Alan, Krueger, Gerald G., Tebbey, Paul W., Belasco, Jennifer, Soltani-Arabshahi, Razieh, Gray, John, Horn, Liz, and Krueger, James G.

Subjects
PSORIASIS, PSORIATIC arthritis, NAIL diseases, JOINT diseases, SYMPTOMS, MEDICAL screening, DATA analysis, PHENOTYPES
Abstract

This study correlated assessment tools for evaluating the severity of skin, nail, and joint symptoms in patients with psoriasis (Pso) and psoriatic arthritis (PsA). Adults with plaque Pso (with or without PsA) were enrolled from four U.S. institutions. Patients were evaluated using a novel 10-area Linear Psoriasis Area and Severity Index (XL-PASI), Psoriatic Arthritis Assessment (PsAA), Psoriatic Arthritis Screening and Evaluation Questionnaire (PASE), Nail Assessment (NA) and Joint Assessment (JA) tools, Psoriasis Weighted Extent and Severity Index (PWESI), and Lattice Physician Global Assessment (LSPGA). Correlations between assessment tools and individual items in the assessment tools were performed. Data from 180 patients (55 with PsA) were analyzed. Highest correlations between tools (r = 0.77-0.88) were between the XL-PASI, PWESI and LS-PGA. Individual items in the XL-PASI correlated with items in the PWESI for extent skin symptoms, but not for all body areas. Overall, correlations were seen between hands and feet, between face and scalp, and between buttocks, chest, and back. Only low correlation was seen between items assessing joint symptoms with items assessing skin symptoms. These data support the notion that the complex phenotype of psoriatic disease requires instruments that assess the severity of skin, nails, and joints separately [ABSTRACT FROM AUTHOR]

Published
2011
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