Search

Your search keyword '"Keller Andreas"' showing total 20 results
Start Over Author "Keller Andreas" Journal plos one
20 results on '"Keller Andreas"'

5. Profiling microRNA expression in murine bone healing and non-union formation: Role of miR-140 during the early stage of bone healing

Author

Orth, Marcel, primary, Scheuer, Claudia, additional, Backes, Christina, additional, Keller, Andreas, additional, Rollmann, Mika F., additional, Braun, Benedikt J., additional, Ludwig, Nicole, additional, Meese, Eckart, additional, Pohlemann, Tim, additional, Laschke, Matthias W., additional, Menger, Michael D., additional, and Histing, Tina, additional

Published
2019
Full Text
View/download PDF

8. Towards Personalized Cardiology: Multi-Scale Modeling of the Failing Heart

Author

Kayvanpour, Elham, primary, Mansi, Tommaso, additional, Sedaghat-Hamedani, Farbod, additional, Amr, Ali, additional, Neumann, Dominik, additional, Georgescu, Bogdan, additional, Seegerer, Philipp, additional, Kamen, Ali, additional, Haas, Jan, additional, Frese, Karen S., additional, Irawati, Maria, additional, Wirsz, Emil, additional, King, Vanessa, additional, Buss, Sebastian, additional, Mereles, Derliz, additional, Zitron, Edgar, additional, Keller, Andreas, additional, Katus, Hugo A., additional, Comaniciu, Dorin, additional, and Meder, Benjamin, additional

Published
2015
Full Text
View/download PDF

9. Combination of Autoantibody Signature with PSA Level Enables a Highly Accurate Blood-Based Differentiation of Prostate Cancer Patients from Patients with Benign Prostatic Hyperplasia

Author

Leidinger, Petra, primary, Keller, Andreas, additional, Milchram, Lisa, additional, Harz, Christian, additional, Hart, Martin, additional, Werth, Angelika, additional, Lenhof, Hans-Peter, additional, Weinhäusel, Andreas, additional, Keck, Bastian, additional, Wullich, Bernd, additional, Ludwig, Nicole, additional, and Meese, Eckart, additional

Published
2015
Full Text
View/download PDF

14. Diagnosis of Pancreatic Ductal Adenocarcinoma and Chronic Pancreatitis by Measurement of microRNA Abundance in Blood and Tissue

Author

Bauer, Andrea S., primary, Keller, Andreas, additional, Costello, Eithne, additional, Greenhalf, William, additional, Bier, Melanie, additional, Borries, Anne, additional, Beier, Markus, additional, Neoptolemos, John, additional, Büchler, Markus, additional, Werner, Jens, additional, Giese, Nathalia, additional, and Hoheisel, Jörg D., additional

Published
2012
Full Text
View/download PDF

15. MicroRNAs Targeting Oncogenes Are Down-Regulated in Pancreatic Malignant Transformation from Benign Tumors

Author

Jiao, Long R., primary, Frampton, Adam E., additional, Jacob, Jimmy, additional, Pellegrino, Loredana, additional, Krell, Jonathan, additional, Giamas, Georgios, additional, Tsim, Nicole, additional, Vlavianos, Panagiotis, additional, Cohen, Patrizia, additional, Ahmad, Raida, additional, Keller, Andreas, additional, Habib, Nagy A., additional, Stebbing, Justin, additional, and Castellano, Leandro, additional

Published
2012
Full Text
View/download PDF

20. Intestinal Salmonella typhimurium Infection Leads to miR-29a Induced Caveolin 2 Regulation.

Author

Hoeke, Lena, Sharbati, Jutta, Pawar, Kamlesh, Keller, Andreas, Einspanier, Ralf, and Sharbati, Soroush

Subjects
INTESTINAL infections, SALMONELLA typhimurium, CAVEOLINS, CELL physiology, MICRORNA, GENETIC regulation, MAMMAL genetics
Abstract

Background: Salmonella are able to modulate host cell functions facilitating both uptake and resistance to cellular host defence mechanisms. While interactions between bacterial modulators and cellular proteins have been the main focus of Salmonella research, relatively little is known about mammalian gene regulation in response to Salmonella infection. A major class of mammalian gene modulators consists of microRNAs. For our study we examined interactions of microRNAs and regulated mRNAs in mammalian intestinal Salmonella infections using a piglet model. Methodology/Principal Findings: After performing microRNA as well as mRNA specific microarray analysis of ileal samples from Salmonella infected as well as control piglets, we integrated expression analysis with target prediction identifying microRNAs that mainly regulate focal adhesion as well as actin cytoskeleton pathways. Particular attention was given to miR-29a, which was involved in most interactions including Caveolin 2. RT-qPCR experiments verified up-regulation of miR-29a after infection while its predicted target Caveolin 2 was significantly down-regulated as examined by transcript and protein detection. Reporter gene assays as well as RNAi experiments confirmed Caveolin 2 to be a miR-29a target. Knock-down of Caveolin 2 in intestinal epithelial cells resulted in retarded proliferation as well as increased bacterial uptake. In addition, our experiments showed that Caveolin 2 regulates the activation of the small Rho GTPase CDC42 but apparently not RAC1 in human intestinal cells. Conclusions/Significance: Our study outlines for the first time important regulation pathways in intestinal Salmonella infection pointing out that focal adhesion and organisation of actin cytoskeleton are regulated by microRNAs. Functional relevance is shown by miR-29a mediated Caveolin 2 regulation, modulating the activation state of CDC42. Further analysis of examined interactions may support the discovery of novel strategies impairing the uptake of intracellular pathogens. [ABSTRACT FROM AUTHOR]

Published
2013
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results