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1. Genetic polymorphisms of interleukin-16 and risk of knee osteoarthritis.

Author

Shi-Xing Luo, Shan Li, Xue-Hui Zhang, Jun-Jing Zhang, Guang-Hua Long, Gui-Fu Dong, Wei Su, Yan Deng, Yanqiong Liu, Jin-Min Zhao, and Xue Qin

Subjects
Medicine, Science
Abstract

Interleukin-16 (IL-16), a pleiotropic cytokine, plays a fundamental role in inflammatory diseases. This study investigates the association between IL-16 polymorphisms and the risk of knee osteoarthritis (OA) in a Chinese population.The IL-16 rs11556218, rs4072111, and rs4778889 polymorphisms were determined in 150 knee OA cases and 147 healthy controls through polymerase chain reaction-restriction fragment length polymorphism.The results suggested that the variants in IL-16 gene rs11556218 site were associated with a decreased knee OA risk after adjusting for age, sex, BMI, and smoking and drinking status (TG vs. TT: OR, 0.69; 95% CI, 0.53-0.89; P = 0.006; GG vs. TT: OR, 0.64; 95% CI, 0.45-0.90; P = 0.042; dominant model: OR, 0.68; 95% CI, 0.29-0.87; P = 0.002; G vs. T allele: OR, 0.77; 95% CI, 0.66-0.90; P = 0.003). Similarly, subjects bearing the rs4072111 variant genotypes and alleles also had a lower susceptibility to knee OA compared with those bearing the wild-type (CT vs. CC: OR, 0.66; 95% CI, 0.53-0.83; P = 0.002; TT vs. CC: OR, 0.57; 95% CI, 0.40-0.82; P = 0.027; dominant model: OR, 0.65; 95%, CI 0.52-0.80; P

Published
2015
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2. Genetic polymorphisms of interleukin-16 and risk of knee osteoarthritis

Author

Shan Li, Yan Deng, Jinmin Zhao, Xue-Hui Zhang, Wei Su, Jun-Jing Zhang, Shixing Luo, Guang-Hua Long, Yanqiong Liu, Xue Qin, and Gui-fu Dong

Subjects
Male, Risk, China, Pathology, medicine.medical_specialty, Genotype, medicine.medical_treatment, lcsh:Medicine, Genome-wide association study, Osteoarthritis, Biology, Polymorphism, Single Nucleotide, Gastroenterology, Asian People, Internal medicine, medicine, Humans, Genetic Predisposition to Disease, Allele, lcsh:Science, Alleles, Aged, Interleukin-16, Multidisciplinary, Haplotype, lcsh:R, Case-control study, Middle Aged, Osteoarthritis, Knee, medicine.disease, Cytokine, Haplotypes, Case-Control Studies, Female, lcsh:Q, Interleukin 16, Polymorphism, Restriction Fragment Length, Research Article
Abstract

Background Interleukin-16 (IL-16), a pleiotropic cytokine, plays a fundamental role in inflammatory diseases. This study investigates the association between IL-16 polymorphisms and the risk of knee osteoarthritis (OA) in a Chinese population. Methods The IL-16 rs11556218, rs4072111, and rs4778889 polymorphisms were determined in 150 knee OA cases and 147 healthy controls through polymerase chain reaction-restriction fragment length polymorphism. Results The results suggested that the variants in IL-16 gene rs11556218 site were associated with a decreased knee OA risk after adjusting for age, sex, BMI, and smoking and drinking status (TG vs. TT: OR, 0.69; 95% CI, 0.53–0.89; P = 0.006; GG vs. TT: OR, 0.64; 95% CI, 0.45–0.90; P = 0.042; dominant model: OR, 0.68; 95% CI, 0.29–0.87; P = 0.002; G vs. T allele: OR, 0.77; 95% CI, 0.66–0.90; P = 0.003). Similarly, subjects bearing the rs4072111 variant genotypes and alleles also had a lower susceptibility to knee OA compared with those bearing the wild-type (CT vs. CC: OR, 0.66; 95% CI, 0.53–0.83; P = 0.002; TT vs. CC: OR, 0.57; 95% CI, 0.40–0.82; P = 0.027; dominant model: OR, 0.65; 95%, CI 0.52–0.80; P

Published
2015

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