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Your search keyword '"José A. Crippa"' showing total 3 results
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3 results on '"José A. Crippa"'

1. Fluorinated cannabidiol derivatives: enhancement of activity in mice models predictive of anxiolytic, antidepressant and antipsychotic effects

Author

Aviva Breuer, Christeene G Haj, Manoela V Fogaça, Felipe V Gomes, Nicole Rodrigues Silva, João Francisco Pedrazzi, Elaine A Del Bel, Jaime C Hallak, José A Crippa, Antonio W Zuardi, Raphael Mechoulam, and Francisco S Guimarães

Subjects
Male, Cannabinoid receptor, Physiology, medicine.medical_treatment, lcsh:Medicine, Anxiety, Pharmacology, Mice, 0302 clinical medicine, Anti-Anxiety Agents, Medicine and Health Sciences, Cannabidiol, Antipsychotics, Biomechanics, lcsh:Science, Mammals, Multidisciplinary, Behavior, Animal, Depression, Drugs, Antidepressants, Animal Models, Anxiety Disorders, Antidepressive Agents, Chemistry, surgical procedures, operative, Schizophrenia, Behavioral Pharmacology, Vertebrates, Physical Sciences, Antidepressant, medicine.symptom, Antipsychotic Agents, medicine.drug, Research Article, Chemical Elements, medicine.drug_class, Motor Activity, Research and Analysis Methods, FARMACOLOGIA, Anxiolytic, digestive system, Rodents, 03 medical and health sciences, Model Organisms, Recreational Drug Use, medicine, Animals, Antipsychotic, Swimming, Depressive Disorder, business.industry, Biological Locomotion, lcsh:R, Amphetamines, Organisms, Correction, Biology and Life Sciences, Fluorine, medicine.disease, digestive system diseases, 030227 psychiatry, Disease Models, Animal, Amniotes, lcsh:Q, business, 030217 neurology & neurosurgery, Anxiolytics
Abstract

Cannabidiol (CBD) is a major Cannabis sativa constituent, which does not cause the typical marijuana psychoactivity. However, it has been shown to be active in a numerous pharmacological assays, including mice tests for anxiety, obsessive-compulsive disorder, depression and schizophrenia. In human trials the doses of CBD needed to achieve effects in anxiety and schizophrenia are high. We report now the synthesis of 3 fluorinated CBD derivatives, one of which, 4'-F-CBD (HUF-101) (1), is considerably more potent than CBD in behavioral assays in mice predictive of anxiolytic, antidepressant, antipsychotic and anti-compulsive activity. Similar to CBD, the anti-compulsive effects of HUF-101 depend on cannabinoid receptors.

Published
2016

2. Correction: Fluorinated Cannabidiol Derivatives: Enhancement of Activity in Mice Models Predictive of Anxiolytic, Antidepressant and Antipsychotic Effects

Author

Aviva Breuer, Christeene G. Haj, Manoela V. Fogaça, Felipe V. Gomes, Nicole Rodrigues Silva, João Francisco Pedrazzi, Elaine A. Del Bel, Jaime C. Hallak, José A. Crippa, Antonio W. Zuardi, Raphael Mechoulam, and Francisco S. Guimarães

Subjects
Multidisciplinary, lcsh:R, lcsh:Medicine, lcsh:Q, lcsh:Science, FARMACOLOGIA
Abstract

[This corrects the article DOI: 10.1371/journal.pone.0158779.].

Published
2016

3. Cross-cultural adaptation and psychometric assessment of a Brazilian-Portuguese version of the Resident Questionnaire.

Author

Karina Pereira-Lima, Ana Paula Casagrande Silva-Rodrigues, Flávia Andressa Farnocchi Marucci, Flávia de Lima Osório, José Alexandre Crippa, and Sonia Regina Loureiro

Subjects
Medicine, Science
Abstract

BACKGROUND:Despite the general agreement regarding the central role of the clinical learning environment in graduate medical education, its assessment remains challenging owing to the lack of available standardized measures. We report on the cross-cultural adaptation and psychometric assessment of the Brazilian-Portuguese version of Seelig's Resident Questionnaire. METHODS:The present study was performed in two steps. First, a cross-cultural translation and adaptation of the Resident Questionnaire was conducted through multiple translations, synthesis of versions, back-translation, content validation, and face validation. Subsequently, a sample of 288 (72%) resident physicians enrolled in 40 residency programs at a Brazilian university hospital completed the following measures: 1) the Brazilian-Portuguese version of the Resident Questionnaire (for factor analysis and to determine internal consistency, reliability, and validity); 2) three existing, validated psychometric measures (to determine convergent and divergent validity); and 3) a self-report questionnaire. RESULTS:Confirmatory factor analysis results provided support for the three-dimensional model of the Resident Questionnaire in use on a sample of Brazilian resident physicians, having been previously verified for use in American samples. All three factors (emotional distress, learning environment satisfaction, and workload satisfaction) verified in the confirmatory factor analysis showed good internal consistency (α > .80), reliability (Raykov's rho > .80), and correlations in the expected directions and magnitude with measures of depressive symptoms, duty hours, organizational conditions, and emotional exhaustion. CONCLUSIONS:This study is the first to adapt a measure of the clinical learning environment of residency programs into Brazilian Portuguese. Our findings suggest that the adapted version of the Resident Questionnaire is valid and reliable for assessing Brazilian residency programs. This free, easy-access, and fast-application instrument may be a useful standardized measure for research and educational purposes concerning the clinical learning environments of resident physicians.

Published
2018
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