1. Can CT Screening Give Rise to a Beneficial Stage Shift in Lung Cancer Patients? Systematic Review and Meta-Analysis.
- Author
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Zixing Wang, Yaoda Hu, Yuyan Wang, Wei Han, Lei Wang, Fang Xue, Xin Sui, Wei Song, Ruihong Shi, and Jingmei Jiang
- Subjects
Medicine ,Science - Abstract
OBJECTIVES:To portray the stage characteristics of lung cancers detected in CT screenings, and explore whether there's universal stage superiority over other methods for various pathological types using available data worldwide in a meta-analysis approach. MATERIALS AND METHODS:EMBASE and MEDLINE were searched for studies on lung cancer CT screening in natural populations through July 2015 without language or other filters. Twenty-four studies (8 trials and 16 cohorts) involving 1875 CT-detected lung cancer patients were enrolled and assessed by QUADAS-2. Pathology-confirmed stage information was carefully extracted by two reviewers. Stage I or limited stage proportions were pooled by random effect model with Freeman-Tukey double arcsine transformation. RESULTS:Pooled stage I cancer proportion in CT screenings was 73.2% (95% confidence interval: 68.6%, 77.5%), with a significant rising trend (Ptrend0.05), and 46.5% (P0.05). CONCLUSION:CT screening can detect more early stage non-small cell lung cancers, but not all of them could be beneficial as there are a considerable number of indolent ones such as bronchioloalveolar adenocarcinomas. Still, current evidence is lacking regarding small cell lung cancers.
- Published
- 2016
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