1. Impairment of myocardial mitochondria in viral myocardial disease and its reflective window in peripheral cells
- Author
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Ming-Xia Chen, Jin-Tao Wei, Hao-Hao Wang, Rui Yan, Dengfeng Gao, Zuyi Yuan, Jian Liu, and Zhi-Quan Liu
- Subjects
Adult ,Cardiomyopathy, Dilated ,Male ,Pathology ,medicine.medical_specialty ,Myocarditis ,Cardiomyopathy ,Cardiology ,lcsh:Medicine ,Coxsackievirus Infections ,Mitochondrion ,Biology ,DNA, Mitochondrial ,Mitochondria, Heart ,medicine ,Medicine and Health Sciences ,Animals ,Humans ,Lymphocytes ,skin and connective tissue diseases ,Inner mitochondrial membrane ,lcsh:Science ,Pathological ,Heart metabolism ,Phospholipids ,Sequence Deletion ,Mice, Inbred BALB C ,Multidisciplinary ,lcsh:R ,Middle Aged ,medicine.disease ,Peripheral ,Disease Models, Animal ,Virus Diseases ,Cardiovascular Diseases ,Heart failure ,Case-Control Studies ,Mitochondrial Membranes ,lcsh:Q ,Female ,sense organs ,Cardiomyopathies ,Research Article - Abstract
Background Viral myocardial disease (VMD) is a common disease inducing heart failure. It has not been clear the roles of mitochondrial damage in the pathological changes of cardiomyocytes in VMD. Methods Myocardial tissues and lymphocytes were collected from 83 VMD patients. Control groups included 12 cases of healthy accidental death with myocardial autopsy and 23 healthy blood donors. The mouse model of viral myocarditis (VMC) was established by Coxsackie virus B3 infection and myocardial tissues and skeletal muscle were collected. Mitochondrial DNA (mtDNA) deletion rate was quantitatively determined using polymerase chain reaction. Results There was significantly difference of myocardial mitochondrial DNA deletion rate between VMD or VMC group and control group (P
- Published
- 2014