1. Medication eluting devices for the field of OBGYN (MEDOBGYN): 3D printed biodegradable hormone eluting constructs, a proof of concept study
- Author
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Jeffery A. Weisman, Udayabhanu Jammalamadaka, J. Mark Meacham, David Mills, David H. Ballard, Pamela K. Woodard, Harika Vemula, Todd Bruno, Karthik Tappa, and Marissa R. Israel
- Subjects
Polymers ,3D printing ,Electronics engineering ,lcsh:Medicine ,Biocompatible Materials ,02 engineering and technology ,Engineering and technology ,Biochemistry ,chemistry.chemical_compound ,0302 clinical medicine ,Drug Delivery Systems ,Absorbable Implants ,Medicine and Health Sciences ,Electron Microscopy ,Lipid Hormones ,lcsh:Science ,Progesterone ,Microscopy ,Multidisciplinary ,Intrauterine Devices, Medicated ,Equipment Design ,021001 nanoscience & nanotechnology ,Enzymes ,Chemistry ,Separation Processes ,Macromolecules ,Proof of concept ,030220 oncology & carcinogenesis ,Drug delivery ,Polycaprolactone ,Physical Sciences ,Printing, Three-Dimensional ,Female ,Scanning Electron Microscopy ,0210 nano-technology ,Oxidoreductases ,Luciferase ,Research Article ,Biotechnology ,3d printed ,Materials science ,Materials by Structure ,Polyesters ,Materials Science ,Research and Analysis Methods ,03 medical and health sciences ,Humans ,business.industry ,lcsh:R ,Biology and Life Sciences ,Proteins ,Estrogens ,Elution ,Pessaries ,Surgical Mesh ,Polymer Chemistry ,Biodegradable polymer ,Hormones ,chemistry ,Enzymology ,Medical Devices and Equipment ,lcsh:Q ,Implant ,business ,Biomedical engineering - Abstract
3D printing has the potential to deliver personalized implants and devices for obstetric and gynecologic applications. The aim of this study is to engineer customizable and biodegradable 3D printed implant materials that can elute estrogen and/or progesterone. All 3D constructs were printed using polycaprolactone (PCL) biodegradable polymer laden with estrogen or progesterone and were subjected to hormone-release profile studies using ELISA kits. Material thermal properties were tested using thermogravimetric analysis and differential scanning calorimetry. The 3D printed constructs showed extended hormonal release over a one week period. Cytocompatibility and bioactivity were assessed using a luciferase assay. The hormone-laden 3D printed constructs demonstrated an increase in luciferase activity and without any deleterious effects. Thermal properties of the PCL and hormones showed degradation temperatures above that of the temperature used in the additive manufacturing process-suggesting that 3D printing can be achieved below the degradation temperatures of the hormones. Sample constructs in the shape of surgical meshes, subdermal rods, intrauterine devices and pessaries were designed and printed. 3D printing of estrogen and progesterone-eluting constructs was feasible in this proof of concept study. These custom designs have the potential to act as a form of personalized medicine for drug delivery and optimized fit based on patient-specific anatomy.
- Published
- 2017