1. Self-reported history of childhood smoking is associated with an increased risk for peripheral arterial disease independent of lifetime smoking burden
- Author
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Nicholas J. Leeper, Kevin T. Nead, Mackenzie R. Wehner, John P. Cooke, and James R. Priest
- Subjects
Pulmonology ,lcsh:Medicine ,Blood Pressure ,Disease ,Cardiovascular ,Pediatrics ,California ,Cohort Studies ,Risk Factors ,Odds Ratio ,Child ,lcsh:Science ,Peripheral Vascular Diseases ,Multidisciplinary ,medicine.diagnostic_test ,Smoking ,Child Health ,3. Good health ,Creatinine ,Cohort ,Regression Analysis ,Medicine ,Public Health ,Behavioral and Social Aspects of Health ,Cohort study ,Research Article ,Adult ,medicine.medical_specialty ,Tobacco Control ,Clinical Research Design ,Childhood obesity ,Peripheral Arterial Disease ,Vascular Biology ,Internal medicine ,medicine ,Humans ,business.industry ,Body Weight ,Cholesterol, HDL ,lcsh:R ,Smoking Related Disorders ,Odds ratio ,medicine.disease ,Atherosclerosis ,Obesity ,Surgery ,Blood pressure ,lcsh:Q ,Lipid profile ,business - Abstract
Atherosclerotic disorders are well known to be associated with obesity, lipid profile, smoking, hypertension and other medical comorbidities, and large cohort studies have explored the childhood correlates to these adult risk factors. However, there has been little investigation into the childhood risk factors for peripheral arterial disease (PAD). We endeavored to better understand the role of smoking in childhood in the risk for PAD in a well described cohort of 1,537 adults at high risk for cardiovascular disease. In a multivariate regression model, we observed an increased risk of PAD among those who reported a history of smoking during childhood (OR = 2.86; 95% CI, 1.99โ4.11; P
- Published
- 2014