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13 results on '"Ishii, Ken"'

3. Identification of HOXD4 Mutations in Spinal Extradural Arachnoid Cyst

Author

Ogura, Yoji, primary, Miyake, Noriko, additional, Kou, Ikuyo, additional, Iida, Aritoshi, additional, Nakajima, Masahiro, additional, Takeda, Kazuki, additional, Fujibayashi, Shunsuke, additional, Shiina, Masaaki, additional, Okada, Eijiro, additional, Toyama, Yoshiaki, additional, Iwanami, Akio, additional, Ishii, Ken, additional, Ogata, Kazuhiro, additional, Asahara, Hiroshi, additional, Matsumoto, Naomichi, additional, Nakamura, Masaya, additional, Matsumoto, Morio, additional, and Ikegawa, Shiro, additional

Published
2015
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4. A Novel Mouse Model of Soft-Tissue Infection Using Bioluminescence Imaging Allows Noninvasive, Real-Time Monitoring of Bacterial Growth

Author

Yoshioka, Kenji, primary, Ishii, Ken, additional, Kuramoto, Tetsuya, additional, Nagai, Shigenori, additional, Funao, Haruki, additional, Ishihama, Hiroko, additional, Shiono, Yuta, additional, Sasaki, Aya, additional, Aizawa, Mamoru, additional, Okada, Yasunori, additional, Koyasu, Shigeo, additional, Toyama, Yoshiaki, additional, and Matsumoto, Morio, additional

Published
2014
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6. Protective Epitopes of the Plasmodium falciparum SERA5 Malaria Vaccine Reside in Intrinsically Unstructured N-Terminal Repetitive Sequences

Author

Yagi, Masanori, primary, Bang, Gilles, additional, Tougan, Takahiro, additional, Palacpac, Nirianne M. Q., additional, Arisue, Nobuko, additional, Aoshi, Taiki, additional, Matsumoto, Yoshitsugu, additional, Ishii, Ken J., additional, Egwang, Thomas G., additional, Druilhe, Pierre, additional, and Horii, Toshihiro, additional

Published
2014
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8. Phase 1b Randomized Trial and Follow-Up Study in Uganda of the Blood-Stage Malaria Vaccine Candidate BK-SE36

Author

Palacpac, Nirianne Marie Q., primary, Ntege, Edward, additional, Yeka, Adoke, additional, Balikagala, Betty, additional, Suzuki, Nahoko, additional, Shirai, Hiroki, additional, Yagi, Masanori, additional, Ito, Kazuya, additional, Fukushima, Wakaba, additional, Hirota, Yoshio, additional, Nsereko, Christopher, additional, Okada, Takuya, additional, Kanoi, Bernard N., additional, Tetsutani, Kohhei, additional, Arisue, Nobuko, additional, Itagaki, Sawako, additional, Tougan, Takahiro, additional, Ishii, Ken J., additional, Ueda, Shigeharu, additional, Egwang, Thomas G., additional, and Horii, Toshihiro, additional

Published
2013
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10. Serologic Markers in Relation to Parasite Exposure History Help to Estimate Transmission Dynamics of Plasmodium vivax

Author

Yildiz Zeyrek, Fadile, primary, Palacpac, Nirianne, additional, Yuksel, Fehmi, additional, Yagi, Masanori, additional, Honjo, Kaori, additional, Fujita, Yukiko, additional, Arisue, Nobuko, additional, Takeo, Satoru, additional, Tanabe, Kazuyuki, additional, Horii, Toshihiro, additional, Tsuboi, Takafumi, additional, Ishii, Ken J., additional, and Coban, Cevayir, additional

Published
2011
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11. Schwann-Spheres Derived from Injured Peripheral Nerves in Adult Mice - Their In Vitro Characterization and Therapeutic Potential

Author

Takagi, Takehiko, primary, Ishii, Ken, additional, Shibata, Shinsuke, additional, Yasuda, Akimasa, additional, Sato, Momoka, additional, Nagoshi, Narihito, additional, Saito, Harukazu, additional, Okano, Hirotaka J., additional, Toyama, Yoshiaki, additional, Okano, Hideyuki, additional, and Nakamura, Masaya, additional

Published
2011
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12. Protective Epitopes of the Plasmodium falciparum SERA5 Malaria Vaccine Reside in Intrinsically Unstructured N-Terminal Repetitive Sequences.

Author

Yagi, Masanori, Bang, Gilles, Tougan, Takahiro, Palacpac, Nirianne M. Q., Arisue, Nobuko, Aoshi, Taiki, Matsumoto, Yoshitsugu, Ishii, Ken J., Egwang, Thomas G., Druilhe, Pierre, and Horii, Toshihiro

Subjects
EPITOPES, PLASMODIUM falciparum, MALARIA, SYMPTOMS, CHEMICAL affinity, GENETIC polymorphisms, VACCINATION
Abstract

The malaria vaccine candidate antigen, SE36, is based on the N-terminal 47 kDa domain of Plasmodium falciparum serine repeat antigen 5 (SERA5). In epidemiological studies, we have previously shown the inhibitory effects of SE36 specific antibodies on in vitro parasite growth and the negative correlation between antibody level and malaria symptoms. A phase 1 b trial of the BK-SE36 vaccine in Uganda elicited 72% protective efficacy against symptomatic malaria in children aged 6–20 years during the follow-up period 130–365 days post–second vaccination. Here, we performed epitope mapping with synthetic peptides covering the whole sequence of SE36 to identify and map dominant epitopes in Ugandan adult serum presumed to have clinical immunity to P. falciparum malaria. High titer sera from the Ugandan adults predominantly reacted with peptides corresponding to two successive N-terminal regions of SERA5 containing octamer repeats and serine rich sequences, regions of SERA5 that were previously reported to have limited polymorphism. Affinity purified antibodies specifically recognizing the octamer repeats and serine rich sequences exhibited a high antibody-dependent cellular inhibition (ADCI) activity that inhibited parasite growth. Furthermore, protein structure predictions and structural analysis of SE36 using spectroscopic methods indicated that N-terminal regions possessing inhibitory epitopes are intrinsically unstructured. Collectively, these results suggest that strict tertiary structure of SE36 epitopes is not required to elicit protective antibodies in naturally immune Ugandan adults. [ABSTRACT FROM AUTHOR]

Published
2014
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13. Serologic Markers in Relation to Parasite Exposure History Help to Estimate Transmission Dynamics of Plasmodium vivax.

Author

Zeyrek, Fadile Yildiz, Palacpac, Nirianne, Yuksel, Fehmi, Yagi, Masanori, Honjo, Kaori, Fujita, Yukiko, Arisue, Nobuko, Takeo, Satoru, Tanabe, Kazuyuki, Horii, Toshihiro, Tsuboi, Takafumi, Ishii, Ken J., and Coban, Cevayir

Subjects
PLASMODIUM vivax, PARASITES, SERODIAGNOSIS, MALARIA
Abstract

Plasmodium vivax infection has been gaining attention because of its re-emergence in several parts of the world. Southeastern Turkey is one of the places in which persistent focal malaria caused exclusively by P. vivax parasites occurs. Although control and elimination studies have been underway for many years, no detailed study has been conducted to understand the mechanisms underlying the ineffective control of malaria in this region. Here, for the first time, using serologic markers we try to extract as much information as possible in this region to get a glimpse of P. vivax transmission. We conducted a sero-immunological study, evaluating antibody responses of individuals living in Sanliurfa to four different P. vivax antigens; three blood-stage antigens (PvMSP119, PvAMA1-ecto, and PvSERA4) and one pre-erythrocytic stage antigen (PvCSP). The results suggest that a prior history of malaria infection and age can be determining factors for the levels and sustainability of naturally acquired antibodies. Significantly higher antibody responses to all the studied antigens were observed in blood smear-negative individuals with a prior history of malaria infection. Moreover, these individuals were significantly older than blood smear-negative individuals with no prior history of infection. These data from an area of sole P. vivax-endemic region may have important implications for the global malaria control/elimination programs and vaccine design. [ABSTRACT FROM AUTHOR]

Published
2011
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