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3. Measurement of Neutralizing Serum Antibodies of Patients Vaccinated with Human Papillomavirus L1 or L2-Based Immunogens Using Furin-Cleaved HPV Pseudovirions

Author

Wang, Joshua W., primary, Jagu, Subhashini, additional, Wang, Chenguang, additional, Kitchener, Henry C., additional, Daayana, Sai, additional, Stern, Peter L., additional, Pang, Susana, additional, Day, Patricia M., additional, Huh, Warner K., additional, and Roden, Richard B. S., additional

Published
2014
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6. Capsomer Vaccines Protect Mice from Vaginal Challenge with Human Papillomavirus.

Author

Wai-Hong Wu, Gersch, Elizabeth, Kwak, Kihyuck, Jagu, Subhashini, Karanam, Balasubramanyam, Huh, Warner K., Garcea, Robert L., and Roden, Richard B. S.

Subjects
PAPILLOMAVIRUSES, GLUTATHIONE, IMMUNOTHERAPY, PREVENTIVE medicine, OLIGOPEPTIDES
Abstract

Capsomers were produced in bacteria as glutathione-S-transferase (GST) fusion proteins with human papillomavirus type 16 L1 lacking the first nine and final 29 residues (GST-HPV16L1Δ) alone or linked with residues 13-47 of HPV18, HPV31 and HPV45 L2 in tandem (GST-HPV16L1Δ-L2x3). Subcutaneous immunization of mice with GST-HPV16L1Δ or GST-HPV16L1ΔL2x3 in alum and monophosphoryl lipid A induced similarly high titers of HPV16 neutralizing antibodies. GST-HPV16L1ΔL2x3 also elicited moderate L2-specific antibody titers. Intravaginal challenge studies showed that immunization of mice with GST-HPV16 L1D or GST-HPV16L1Δ-L2x3 capsomers, like Cervarix®, provided complete protection against HPV16. Conversely, vaccination with GST-HPV16 L1D capsomers failed to protect against HPV18 challenge, whereas mice immunized with either GST-HPV16L1Δ-L2x3 capsomers or Cervarix® were each completely protected. Thus, while the L2-specific response was moderate, it did not interfere with immunity to L1 in the context of GST-HPV16L1Δ-L2x3 and is sufficient to mediate L2-dependent protection against an experimental vaginal challenge with HPV18. [ABSTRACT FROM AUTHOR]

Published
2011
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