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Your search keyword '"Goodings, Charnise"' showing total 3 results
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3 results on '"Goodings, Charnise"'

1. Family-based exome-wide association study of childhood acute lymphoblastic leukemia among Hispanics confirms role of ARID5B in susceptibility

Author

Archer, Natalie P., primary, Perez-Andreu, Virginia, additional, Stoltze, Ulrik, additional, Scheurer, Michael E., additional, Wilkinson, Anna V., additional, Lin, Ting-Nien, additional, Qian, Maoxiang, additional, Goodings, Charnise, additional, Swartz, Michael D., additional, Ranjit, Nalini, additional, Rabin, Karen R., additional, Peckham-Gregory, Erin C., additional, Plon, Sharon E., additional, de Alarcon, Pedro A., additional, Zabriskie, Ryan C., additional, Antillon-Klussmann, Federico, additional, Najera, Cesar R., additional, Yang, Jun J., additional, and Lupo, Philip J., additional

Published
2017
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2. LIM Domain Only-2 (LMO2) Induces T-Cell Leukemia by Two Distinct Pathways

Author

Smith, Stephen, primary, Tripathi, Rati, additional, Goodings, Charnise, additional, Cleveland, Susan, additional, Mathias, Elizabeth, additional, Hardaway, J. Andrew, additional, Elliott, Natalina, additional, Yi, Yajun, additional, Chen, Xi, additional, Downing, James, additional, Mullighan, Charles, additional, Swing, Deborah A., additional, Tessarollo, Lino, additional, Li, Liqi, additional, Love, Paul, additional, Jenkins, Nancy A., additional, Copeland, Neal G., additional, Thompson, Mary Ann, additional, Du, Yang, additional, and Davé, Utpal P., additional

Published
2014
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3. LIM Domain Only-2 (LMO2) Induces T-Cell Leukemia by Two Distinct Pathways.

Author

Smith, Stephen, Tripathi, Rati, Goodings, Charnise, Cleveland, Susan, Mathias, Elizabeth, Hardaway, J. Andrew, Elliott, Natalina, Yi, Yajun, Chen, Xi, Downing, James, Mullighan, Charles, Swing, Deborah A., Tessarollo, Lino, Li, Liqi, Love, Paul, Jenkins, Nancy A., Copeland, Neal G., Thompson, Mary Ann, Du, Yang, and Davé, Utpal P.

Subjects
LEUKEMIA treatment, T cells, ONCOGENES, GENE therapy, TRANSGENIC mice, GENE expression, CD2 antigen, PROMOTERS (Genetics)
Abstract

The LMO2 oncogene is deregulated in the majority of human T-cell leukemia cases and in most gene therapy-induced T-cell leukemias. We made transgenic mice with enforced expression of Lmo2 in T-cells by the CD2 promoter/enhancer. These transgenic mice developed highly penetrant T-ALL by two distinct patterns of gene expression: one in which there was concordant activation of Lyl1, Hhex, and Mycn or alternatively, with Notch1 target gene activation. Most strikingly, this gene expression clustering was conserved in human Early T-cell Precursor ALL (ETP-ALL), where LMO2, HHEX, LYL1, and MYCN were most highly expressed. We discovered that HHEX is a direct transcriptional target of LMO2 consistent with its concordant gene expression. Furthermore, conditional inactivation of Hhex in CD2-Lmo2 transgenic mice markedly attenuated T-ALL development, demonstrating that Hhex is a crucial mediator of Lmo2's oncogenic function. The CD2-Lmo2 transgenic mice offer mechanistic insight into concordant oncogene expression and provide a model for the highly treatment-resistant ETP-ALL subtype. [ABSTRACT FROM AUTHOR]

Published
2014
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