1. Lactate production without hypoxia in skeletal muscle during electrical cycling: Crossover study of femoral venous-arterial differences in healthy volunteers
- Author
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Gojda, Jan, Waldauf, Petr, Hrušková, Natália, Blahutová, Barbora, Krajčová, Adéla, Urban, Tomáš, Tůma, Petr, Řasová, Kamila, and Duška, František
- Subjects
Male ,Atmospheric Science ,Physiology ,Blood Flow ,Medicine and Health Sciences ,Supine Position ,Public and Occupational Health ,Amino Acids ,Musculoskeletal System ,Cross-Over Studies ,Muscles ,Sports Science ,Healthy Volunteers ,Body Fluids ,Exercise Therapy ,Femoral Artery ,Chemistry ,Blood ,Physical Sciences ,Legs ,Medicine ,Female ,Anatomy ,Research Article ,Chemical Elements ,Adult ,Science ,Surgical and Invasive Medical Procedures ,Greenhouse Gases ,Young Adult ,Oxygen Consumption ,Environmental Chemistry ,Humans ,Lactic Acid ,Sports and Exercise Medicine ,Muscle, Skeletal ,Exercise ,Leg ,Functional Electrical Stimulation ,Ecology and Environmental Sciences ,Chemical Compounds ,Biology and Life Sciences ,Calorimetry, Indirect ,Physical Activity ,Carbon Dioxide ,Femoral Vein ,Electric Stimulation ,Bicycling ,Oxygen ,Skeletal Muscles ,Physical Fitness ,Atmospheric Chemistry ,Body Limbs ,Earth Sciences - Abstract
Background Aim of the study was to compare metabolic response of leg skeletal muscle during functional electrical stimulation-driven unloaded cycling (FES) to that seen during volitional supine cycling. Methods Fourteen healthy volunteers were exposed in random order to supine cycling, either volitional (10-25-50 W, 10 min) or FES assisted (unloaded, 10 min) in a crossover design. Whole body and leg muscle metabolism were assessed by indirect calorimetry with concomitant repeated measurements of femoral venous-arterial differences of blood gases, glucose, lactate and amino acids. Results Unloaded FES cycling, but not volitional exercise, led to a significant increase in across-leg lactate production (from -1.1±2.1 to 5.5±7.4 mmol/min, p
- Published
- 2019