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2 results on '"George Papatsibas"'

1. Associations of angiogenesis-related proteins with specific prognostic factors, breast cancer subtypes and survival outcome in early-stage breast cancer patients. A Hellenic Cooperative Oncology Group (HeCOG) trial.

Author

Anna Goussia, Nafsika Simou, Flora Zagouri, Kyriaki Manousou, Georgios Lazaridis, Helen Gogas, Angelos Koutras, Maria Sotiropoulou, George Pentheroudakis, Dimitrios Bafaloukos, Christos Markopoulos, Helen Patsea, Christos Christodoulou, Pavlos Papakostas, Thomas Zaramboukas, Epaminontas Samantas, Paris Kosmidis, Vasileios Venizelos, Charisios Karanikiotis, George Papatsibas, Grigorios Xepapadakis, Konstantine T Kalogeras, Christina Bamia, Meletios-Athanassios Dimopoulos, Vassiliki Malamou-Mitsi, George Fountzilas, and Anna Batistatou

Subjects
Medicine, Science
Abstract

Several studies support an important role of angiogenesis in breast cancer growth and metastasis. The main objectives of the study were to investigate the immunohistochemical expression of vascular endothelial growth factor (VEGF) family ligands (VEGF-A and VEGF-C) and receptors (VEGFR1, VEGFR2 and VEGFR3) in breast cancer and their associations with clinicopathological parameters, cancer subtypes/subgroups and patient outcome. Formalin-fixed paraffin-embedded tumor tissue samples were collected from early-stage breast cancer patients treated with anthracycline-based chemotherapy within a randomized trial. Immunohistochemistry was performed on serial 2.5 μm thick tissue sections from tissue microarray blocks. High VEGF-A, VEGF-C, VEGFR1, VEGFR2 and VEGFR3 protein expression was observed in 11.8% (N = 87), 80.8% (N = 585), 28.1% (N = 202), 64.6% (N = 359) and 71.8% (N = 517) of the cases, respectively. Significant associations were observed among all proteins (all p-values

Published
2018
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2. Associations of angiogenesis-related proteins with specific prognostic factors, breast cancer subtypes and survival outcome in early-stage breast cancer patients. A Hellenic Cooperative Oncology Group (HeCOG) trial

Author

Epaminontas Samantas, Christos Markopoulos, Christos Christodoulou, Charisios Karanikiotis, Georgios Lazaridis, George Papatsibas, George Pentheroudakis, Nafsika Simou, Christina Bamia, Maria Sotiropoulou, Meletios-Athanassios Dimopoulos, Vassiliki Malamou-Mitsi, Helen Gogas, George Fountzilas, Konstantine T. Kalogeras, Pavlos Papakostas, Kyriaki Manousou, Angelos Koutras, Helen Patsea, Anna Batistatou, Grigorios Xepapadakis, V. Venizelos, Flora Zagouri, Anna Goussia, Dimitrios Bafaloukos, Thomas Zaramboukas, and Paris Kosmidis

Subjects
0301 basic medicine, Oncology, Vascular Endothelial Growth Factor A, Angiogenesis, Physiology, Protein Expression, Vascular Endothelial Growth Factor C, Cancer Treatment, lcsh:Medicine, Cardiovascular Physiology, Chi Square Tests, Metastasis, chemistry.chemical_compound, 0302 clinical medicine, Mathematical and Statistical Techniques, Breast Tumors, Medicine and Health Sciences, Medicine, Breast, lcsh:Science, Staining, Multidisciplinary, Tissue microarray, Neovascularization, Pathologic, Cell Staining, Middle Aged, Prognosis, Vascular endothelial growth factor, 030220 oncology & carcinogenesis, Physical Sciences, Immunohistochemistry, Female, Anatomy, Statistics (Mathematics), Research Article, Adult, medicine.medical_specialty, Anthracycline, Breast Neoplasms, Research and Analysis Methods, Lymphatic System, 03 medical and health sciences, Young Adult, Breast cancer, Internal medicine, Breast Cancer, Gene Expression and Vector Techniques, Humans, Statistical Methods, Molecular Biology Techniques, Molecular Biology, Statistical Hypothesis Testing, Aged, Proportional Hazards Models, Molecular Biology Assays and Analysis Techniques, business.industry, lcsh:R, Cancer, Cancers and Neoplasms, Biology and Life Sciences, medicine.disease, Vascular Endothelial Growth Factor Receptor-3, Vascular Endothelial Growth Factor Receptor-2, 030104 developmental biology, chemistry, Specimen Preparation and Treatment, lcsh:Q, Lymph Nodes, business, Mathematics, Developmental Biology
Abstract

Several studies support an important role of angiogenesis in breast cancer growth and metastasis. The main objectives of the study were to investigate the immunohistochemical expression of vascular endothelial growth factor (VEGF) family ligands (VEGF-A and VEGF-C) and receptors (VEGFR1, VEGFR2 and VEGFR3) in breast cancer and their associations with clinicopathological parameters, cancer subtypes/subgroups and patient outcome. Formalin-fixed paraffin-embedded tumor tissue samples were collected from early-stage breast cancer patients treated with anthracycline-based chemotherapy within a randomized trial. Immunohistochemistry was performed on serial 2.5 μm thick tissue sections from tissue microarray blocks. High VEGF-A, VEGF-C, VEGFR1, VEGFR2 and VEGFR3 protein expression was observed in 11.8% (N = 87), 80.8% (N = 585), 28.1% (N = 202), 64.6% (N = 359) and 71.8% (N = 517) of the cases, respectively. Significant associations were observed among all proteins (all p-values

Published
2018

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