A Body Shape Index (ABSI) predicts mortality independent of body mass index and had a negative relationship with self-rated health (SRH), which had a positive effect on the EuroQol (EQ)-5D index. This study aimed to investigate the relationship between ABSI and the EQ-5D index and to verify the mediating effect of SRH in Korean adults. This study included 13,381 participants aged ≥20 years from the 7th (2016-2018) Korean National Health and Nutrition Examination Survey (KNHANES). The participants were classified into tertile groups based on the ABSI (T1, T2, and T3 groups). Demographic characteristics, health-related factors, ABSI, SRH, and EQ-5D scores were evaluated. Women (p