Search

Your search keyword '"Etienne Paubelle"' showing total 2 results
Start Over Author "Etienne Paubelle" Journal plos one
2 results on '"Etienne Paubelle"'

1. Deferasirox and vitamin D improves overall survival in elderly patients with acute myeloid leukemia after demethylating agents failure.

Author

Etienne Paubelle, Florence Zylbersztejn, Sawsaneh Alkhaeir, Felipe Suarez, Céline Callens, Michaël Dussiot, Françoise Isnard, Marie-Thérèse Rubio, Gandhi Damaj, Norbert-Claude Gorin, Jean-Pierre Marolleau, Renato C Monteiro, Ivan C Moura, and Olivier Hermine

Subjects
Medicine, Science
Abstract

The prognosis of acute myeloid leukemia (AML) in elderly (≥65 years) patients is poor and treatment remains non-consensual especially for those who are not eligible for intensive therapies. Our group has shown that in vitro the iron chelator deferasirox (DFX) synergizes with vitamin D (VD) to promote monocyte differentiation in primary AML cells. Herein, we present results from a retrospective case-control study in which the association of DFX (1-2 g/d) and 25-hydroxycholecalciferol (100,000 IU/week) (DFX/VD) was proposed to patients following demethylating agents failure. Median survival of patients treated with DFX/VD combination (n = 17) was significantly increased in comparison with matched patients receiving best supportive care (BSC) alone (n = 13) (10.4 versus 4 months respectively). In addition, the only factor associated to an increased overall survival in DFX/VD-treated patients was serum VD levels. We conclude that DFX/VD treatment correlated with increased overall survival of AML patients in this retrospective cohort of elderly patients.

Published
2013
Full Text
View/download PDF

2. Deferasirox and vitamin D improves overall survival in elderly patients with acute myeloid leukemia after demethylating agents failure

Author

Olivier Hermine, Jean-Pierre Marolleau, Ivan C. Moura, Renato C. Monteiro, Etienne Paubelle, Gandhi Damaj, Sawsaneh Alkhaeir, Michael Dussiot, Norbert-Claude Gorin, Céline Callens, Felipe Suarez, Florence Zylbersztejn, Marie-Thérèse Rubio, and Françoise Isnard

Subjects
Oncology, Male, Aging, Myeloid, Aging and Cancer, Kaplan-Meier Estimate, Benzoates, Hematologic Cancers and Related Disorders, Antineoplastic Combined Chemotherapy Protocols, Medicine, Myeloid Cells, DNA (Cytosine-5-)-Methyltransferases, Vitamin D, Aged, 80 and over, Multidisciplinary, Cancer Risk Factors, Myeloid leukemia, Cell Differentiation, Drug Synergism, Hematology, Vitamins, Middle Aged, Leukemia, Leukemia, Myeloid, Acute, medicine.anatomical_structure, Treatment Outcome, Monocyte differentiation, Azacitidine, Female, medicine.drug, Research Article, Acute Myeloid Leukemia, medicine.medical_specialty, Science, Internal medicine, Leukemias, Vitamin D and neurology, Humans, Biology, Aged, Proportional Hazards Models, Retrospective Studies, Nutrition, Population Biology, business.industry, Deferasirox, Case-control study, Cancers and Neoplasms, Retrospective cohort study, Triazoles, medicine.disease, Drug Resistance, Neoplasm, Case-Control Studies, Immunology, business
Abstract

The prognosis of acute myeloid leukemia (AML) in elderly (≥65 years) patients is poor and treatment remains non-consensual especially for those who are not eligible for intensive therapies. Our group has shown that in vitro the iron chelator deferasirox (DFX) synergizes with vitamin D (VD) to promote monocyte differentiation in primary AML cells. Herein, we present results from a retrospective case-control study in which the association of DFX (1-2 g/d) and 25-hydroxycholecalciferol (100,000 IU/week) (DFX/VD) was proposed to patients following demethylating agents failure. Median survival of patients treated with DFX/VD combination (n = 17) was significantly increased in comparison with matched patients receiving best supportive care (BSC) alone (n = 13) (10.4 versus 4 months respectively). In addition, the only factor associated to an increased overall survival in DFX/VD-treated patients was serum VD levels. We conclude that DFX/VD treatment correlated with increased overall survival of AML patients in this retrospective cohort of elderly patients.

Published
2013

Catalog

Books, media, physical & digital resources
See catalog results