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2 results on '"Detlef Thieme"'

1. Motion sickness, stress and the endocannabinoid system.

Author

Alexander Choukèr, Ines Kaufmann, Simone Kreth, Daniela Hauer, Matthias Feuerecker, Detlef Thieme, Michael Vogeser, Manfred Thiel, and Gustav Schelling

Subjects
Medicine, Science
Abstract

BACKGROUND: A substantial number of individuals are at risk for the development of motion sickness induced nausea and vomiting (N&V) during road, air or sea travel. Motion sickness can be extremely stressful but the neurobiologic mechanisms leading to motion sickness are not clear. The endocannabinoid system (ECS) represents an important neuromodulator of stress and N&V. Inhibitory effects of the ECS on N&V are mediated by endocannabinoid-receptor activation. METHODOLOGY/PRINCIPAL FINDINGS: We studied the activity of the ECS in human volunteers (n = 21) during parabolic flight maneuvers (PFs). During PFs, microgravity conditions (

Published
2010
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2. Motion Sickness, Stress and the Endocannabinoid System

Author

Michael Vogeser, Manfred Thiel, Detlef Thieme, Gustav Schelling, Simone Kreth, Alexander Choukèr, Daniela Hauer, Matthias Feuerecker, and Ines Kaufmann

Subjects
Adult, Male, Hypothalamo-Hypophyseal System, medicine.medical_specialty, Cannabinoid receptor, Aircraft, Hydrocortisone, Motion Sickness, Nausea, Public Health and Epidemiology, Pituitary-Adrenal System, lcsh:Medicine, Poison control, chemistry.chemical_compound, Stress, Physiological, Internal medicine, Cannabinoid Receptor Modulators, medicine, Humans, Receptors, Cannabinoid, lcsh:Science, Demography, Multidisciplinary, Physiology/Endocrinology, business.industry, lcsh:R, Physiology/Neural Homeostasis, Anandamide, medicine.disease, Endocannabinoid system, Motion sickness, Endocrinology, Gene Expression Regulation, chemistry, Anesthesia, Vomiting, lcsh:Q, medicine.symptom, business, Research Article, Endocannabinoids, medicine.drug
Abstract

BACKGROUND: A substantial number of individuals are at risk for the development of motion sickness induced nausea and vomiting (N&V) during road, air or sea travel. Motion sickness can be extremely stressful but the neurobiologic mechanisms leading to motion sickness are not clear. The endocannabinoid system (ECS) represents an important neuromodulator of stress and N&V. Inhibitory effects of the ECS on N&V are mediated by endocannabinoid-receptor activation. METHODOLOGY/PRINCIPAL FINDINGS: We studied the activity of the ECS in human volunteers (n = 21) during parabolic flight maneuvers (PFs). During PFs, microgravity conditions (

Published
2010

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