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2 results on '"Daniel DiRenzo"'

1. TGF-β/Smad3 stimulates stem cell/developmental gene expression and vascular smooth muscle cell de-differentiation.

Author

Xudong Shi, Daniel DiRenzo, Lian-Wang Guo, Sarah R Franco, Bowen Wang, Stephen Seedial, and K Craig Kent

Subjects
Medicine, Science
Abstract

Atherosclerotic-associated diseases are the leading cause of death in the United States. Despite recent progress, interventional treatments for atherosclerosis can be complicated by restenosis resulting from neo-intimal hyperplasia. We have previously demonstrated that TGF-β and its downstream signaling protein Smad3 ∶ 1) are up-regulated following vascular injury, 2) together drive smooth muscle cell (SMC) proliferation and migration and 3) enhance the development of intimal hyperplasia. In order to determine a mechanism through which TGF-β/Smad3 promote these effects, Affymetrix gene expression arrays were performed on primary rat SMCs infected with Smad3 and stimulated with TGF-β or infected with GFP alone. More than 200 genes were differentially expressed (>2.0 fold change, p

Published
2014
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2. TGF-β/Smad3 Stimulates Stem Cell/Developmental Gene Expression and Vascular Smooth Muscle Cell De-Differentiation

Author

Sarah Franco, Stephen Seedial, K. Craig Kent, Daniel DiRenzo, Lian-Wang Guo, Xudong Shi, and Bowen Wang

Subjects
Male, Vascular smooth muscle, Transcription, Genetic, Microarrays, Cellular differentiation, Gene Expression, Muscle Proteins, Vascular Medicine, Muscle, Smooth, Vascular, Rats, Sprague-Dawley, Genes, Reporter, Transduction, Genetic, Gene expression, Molecular Cell Biology, Medicine and Health Sciences, Aorta, Cells, Cultured, Regulation of gene expression, Multidisciplinary, biology, Gene Expression Regulation, Developmental, Bioassays and Physiological Analysis, Medicine, Stem cell, Cell Division, Research Article, Science, Recombinant Fusion Proteins, Calponin, Myocytes, Smooth Muscle, Cardiology, Research and Analysis Methods, Real-Time Polymerase Chain Reaction, Molecular Genetics, Transforming Growth Factor beta1, Genetics, Animals, Smad3 Protein, Progenitor cell, Hyperplasia, Gene Expression Profiling, Biology and Life Sciences, Computational Biology, Cell Biology, Cell Dedifferentiation, Atherosclerosis, Molecular biology, Fold change, Rats, biology.protein, Transcriptome, Tunica Intima
Abstract

Atherosclerotic-associated diseases are the leading cause of death in the United States. Despite recent progress, interventional treatments for atherosclerosis can be complicated by restenosis resulting from neo-intimal hyperplasia. We have previously demonstrated that TGF-β and its downstream signaling protein Smad3 ∶ 1) are up-regulated following vascular injury, 2) together drive smooth muscle cell (SMC) proliferation and migration and 3) enhance the development of intimal hyperplasia. In order to determine a mechanism through which TGF-β/Smad3 promote these effects, Affymetrix gene expression arrays were performed on primary rat SMCs infected with Smad3 and stimulated with TGF-β or infected with GFP alone. More than 200 genes were differentially expressed (>2.0 fold change, p

Published
2014

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