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Your search keyword '"Cox, Jonathan"' showing total 8 results
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8 results on '"Cox, Jonathan"'

1. Dihydrofolate-Reductase Mutations in Plasmodium knowlesi Appear Unrelated to Selective Drug Pressure from Putative Human-To-Human Transmission in Sabah, Malaysia

Author

Grigg, Matthew J., primary, Barber, Bridget E., additional, Marfurt, Jutta, additional, Imwong, Mallika, additional, William, Timothy, additional, Bird, Elspeth, additional, Piera, Kim A., additional, Aziz, Ammar, additional, Boonyuen, Usa, additional, Drakeley, Christopher J., additional, Cox, Jonathan, additional, White, Nicholas J., additional, Cheng, Qin, additional, Yeo, Tsin W., additional, Auburn, Sarah, additional, and Anstey, Nicholas M., additional

Published
2016
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2. Mycobacterial Dihydrofolate Reductase Inhibitors Identified Using Chemogenomic Methods and In Vitro Validation

Author

Mugumbate, Grace, primary, Abrahams, Katherine A., additional, Cox, Jonathan A. G., additional, Papadatos, George, additional, van Westen, Gerard, additional, Lelièvre, Joël, additional, Calus, Szymon T., additional, Loman, Nicholas J., additional, Ballell, Lluis, additional, Barros, David, additional, Overington, John P., additional, and Besra, Gurdyal S., additional

Published
2015
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3. Biochemical and Structural Characterization of Mycobacterial Aspartyl-tRNA Synthetase AspS, a Promising TB Drug Target

Author

Gurcha, Sudagar S., primary, Usha, Veeraraghavan, additional, Cox, Jonathan A. G., additional, Fütterer, Klaus, additional, Abrahams, Katherine A., additional, Bhatt, Apoorva, additional, Alderwick, Luke J., additional, Reynolds, Robert C., additional, Loman, Nicholas J., additional, Nataraj, VijayaShankar, additional, Alemparte, Carlos, additional, Barros, David, additional, Lloyd, Adrian J., additional, Ballell, Lluis, additional, Hobrath, Judith V., additional, and Besra, Gurdyal S., additional

Published
2014
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5. Reliability of School Surveys in Estimating Geographic Variation in Malaria Transmission in the Western Kenyan Highlands

Author

Stevenson, Jennifer C., primary, Stresman, Gillian H., additional, Gitonga, Caroline W., additional, Gillig, Jonathan, additional, Owaga, Chrispin, additional, Marube, Elizabeth, additional, Odongo, Wycliffe, additional, Okoth, Albert, additional, China, Pauline, additional, Oriango, Robin, additional, Brooker, Simon J., additional, Bousema, Teun, additional, Drakeley, Chris, additional, and Cox, Jonathan, additional

Published
2013
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7. Identification of Novel Imidazo[1,2-a]pyridine Inhibitors Targeting M. tuberculosis QcrB

Author

Abrahams, Katherine A., primary, Cox, Jonathan A. G., additional, Spivey, Vickey L., additional, Loman, Nicholas J., additional, Pallen, Mark J., additional, Constantinidou, Chrystala, additional, Fernández, Raquel, additional, Alemparte, Carlos, additional, Remuiñán, Modesto J., additional, Barros, David, additional, Ballell, Lluis, additional, and Besra, Gurdyal S., additional

Published
2012
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8. A Computational Study of the Hydrodynamics in the Nasal Region of a Hammerhead Shark (Sphyrna tudes): Implications for Olfaction.

Author

Rygg, Alex D., Cox, Jonathan P. L., Abel, Richard, Webb, Andrew G., Smith, Nadine B., and Craven, Brent A.

Subjects
*HYDRODYNAMICS, *HAMMERHEAD sharks, *SMELL, *FISH morphology, *EPITHELIUM, *MAGNETIC resonance imaging, *COMPUTATIONAL fluid dynamics
Abstract

The hammerhead shark possesses a unique head morphology that is thought to facilitate enhanced olfactory performance. The olfactory chambers, located at the distal ends of the cephalofoil, contain numerous lamellae that increase the surface area for olfaction. Functionally, for the shark to detect chemical stimuli, water-borne odors must reach the olfactory sensory epithelium that lines these lamellae. Thus, odorant transport from the aquatic environment to the sensory epithelium is the first critical step in olfaction. Here we investigate the hydrodynamics of olfaction in Sphyrna tudes based on an anatomically-accurate reconstruction of the head and olfactory chamber from high-resolution micro-CT and MRI scans of a cadaver specimen. Computational fluid dynamics simulations of water flow in the reconstructed model reveal the external and internal hydrodynamics of olfaction during swimming. Computed external flow patterns elucidate the occurrence of flow phenomena that result in high and low pressures at the incurrent and excurrent nostrils, respectively, which induces flow through the olfactory chamber. The major (prenarial) nasal groove along the cephalofoil is shown to facilitate sampling of a large spatial extent (i.e., an extended hydrodynamic “reach”) by directing oncoming flow towards the incurrent nostril. Further, both the major and minor nasal grooves redirect some flow away from the incurrent nostril, thereby limiting the amount of fluid that enters the olfactory chamber. Internal hydrodynamic flow patterns are also revealed, where we show that flow rates within the sensory channels between olfactory lamellae are passively regulated by the apical gap, which functions as a partial bypass for flow in the olfactory chamber. Consequently, the hammerhead shark appears to utilize external (major and minor nasal grooves) and internal (apical gap) flow regulation mechanisms to limit water flow between the olfactory lamellae, thus protecting these delicate structures from otherwise high flow rates incurred by sampling a larger area. [ABSTRACT FROM AUTHOR]

Published
2013
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