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4 results on '"Chien-Ming Lo"'

1. The clinical impact of supraclavicular lymph node metastasis in patients with locally advanced esophageal squamous cell carcinoma receiving curative concurrent chemoradiotherapy.

Author

Yen-Hao Chen, Hung-I Lu, Chien-Ming Lo, Yu-Ming Wang, Shang-Yu Chou, Cheng-Hua Huang, Li-Hsueh Shih, Su-Wei Chen, and Shau-Hsuan Li

Subjects
Medicine, Science
Abstract

BACKGROUND:To evaluate the clinical significance of supraclavicular lymph node (SCLN) in patients with locally advanced esophageal squamous cell carcinoma (ESCC) receiving curative concurrent chemoradiotherapy (CCRT). MATERIALS AND METHODS:We retrospectively analyzed all 369 locally advanced ESCC patients treated with CCRT between 2000 and 2015, including 70 patients with SCLN metastasis and 299 patients without SCLN metastasis. RESULTS:For these locally advanced ESCC patients treated with curative CCRT, N0-2 were significantly associated with superior progression-free survival (PFS) and overall survival (OS) in univariate and multivariable analyses. However, there were no significant differences in PFS and OS between the SCLN metastasis and non-SCLN metastasis groups; a subgroup analysis also revealed there was no significant differences in PFS and OS between patients with and without SCLN metastasis either in the N0-2 or in the N3 subgroup analysis. CONCLUSIONS:Our study suggests that SCLN metastasis is not a prognostic factor in locally advanced ESCC patients receiving curative CCRT, and that SCLNs should be considered to be regional LNs and treated with curative intent.

Published
2018
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2. Areca nut is associated with younger age of diagnosis, poor chemoradiotherapy response, and shorter overall survival in esophageal squamous cell carcinoma.

Author

Chang-Han Chen, Hung-I Lu, Yu-Ming Wang, Yen-Hao Chen, Chien-Ming Lo, Wan-Ting Huang, and Shau-Hsuan Li

Subjects
Medicine, Science
Abstract

OBJECTIVE:Areca nut chewing is carcinogenic to humans. However, little is known about the impact of areca nut chewing on esophageal squamous cell carcinoma (ESCC). METHODS:We retrospectively reviewed 286 ESCC patients who received surgery or preoperative chemoradiotherapy followed by surgery at our institution. Background characteristics including areca nut chewing history were analyzed. The 4-nitroquinoline 1-oxide (4-NQO)-induced murine ESCC model was used to test the impact of arecoline, a main constituent of areca nut, on ESCC. RESULTS:Compared to patients without areca nut chewing history, patients with areca nut chewing history had overall a younger age of onset (Mean age: 56.75 versus 52.68 yrs, P

Published
2017
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3. The clinical impact of supraclavicular lymph node metastasis in patients with locally advanced esophageal squamous cell carcinoma receiving curative concurrent chemoradiotherapy

Author

Li-Hsueh Shih, Su-Wei Chen, Yen-Hao Chen, Shang-Yu Chou, Chien-Ming Lo, Yu-Ming Wang, Shau-Hsuan Li, Hung-I Lu, and Cheng-Hua Huang

Subjects
Oncology, Male, medicine.medical_specialty, Databases, Factual, Esophageal Neoplasms, medicine.medical_treatment, lcsh:Medicine, Subgroup analysis, Disease-Free Survival, Metastasis, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, Carcinoma, Medicine, Humans, lcsh:Science, neoplasms, Survival analysis, Neoplasm Staging, Retrospective Studies, Multidisciplinary, business.industry, lcsh:R, Chemoradiotherapy, Esophageal cancer, Middle Aged, medicine.disease, Survival Analysis, Supraclavicular lymph nodes, Radiation therapy, medicine.anatomical_structure, 030220 oncology & carcinogenesis, Lymphatic Metastasis, Carcinoma, Squamous Cell, lcsh:Q, 030211 gastroenterology & hepatology, Female, business
Abstract

Background To evaluate the clinical significance of supraclavicular lymph node (SCLN) in patients with locally advanced esophageal squamous cell carcinoma (ESCC) receiving curative concurrent chemoradiotherapy (CCRT). Materials and methods We retrospectively analyzed all 369 locally advanced ESCC patients treated with CCRT between 2000 and 2015, including 70 patients with SCLN metastasis and 299 patients without SCLN metastasis. Results For these locally advanced ESCC patients treated with curative CCRT, N0-2 were significantly associated with superior progression-free survival (PFS) and overall survival (OS) in univariate and multivariable analyses. However, there were no significant differences in PFS and OS between the SCLN metastasis and non-SCLN metastasis groups; a subgroup analysis also revealed there was no significant differences in PFS and OS between patients with and without SCLN metastasis either in the N0-2 or in the N3 subgroup analysis. Conclusions Our study suggests that SCLN metastasis is not a prognostic factor in locally advanced ESCC patients receiving curative CCRT, and that SCLNs should be considered to be regional LNs and treated with curative intent.

Published
2017

4. Areca nut is associated with younger age of diagnosis, poor chemoradiotherapy response, and shorter overall survival in esophageal squamous cell carcinoma

Author

Yu-Ming Wang, Shau-Hsuan Li, Hung-I Lu, Chien-Ming Lo, Wan-Ting Huang, Yen-Hao Chen, and Chang-Han Chen

Subjects
0301 basic medicine, Oncology, Male, Esophageal Neoplasms, Cancer Treatment, lcsh:Medicine, Kaplan-Meier Estimate, Pathology and Laboratory Medicine, Mice, 0302 clinical medicine, Medicine and Health Sciences, Nuts, lcsh:Science, Areca, Aged, 80 and over, Multidisciplinary, biology, Pharmaceutics, Incidence (epidemiology), digestive, oral, and skin physiology, food and beverages, Squamous Cell Carcinomas, Chemoradiotherapy, Animal Models, Middle Aged, Immunohistochemistry, 4-Nitroquinoline-1-oxide, Surgical Oncology, Experimental Organism Systems, 030220 oncology & carcinogenesis, Carcinoma, Squamous Cell, Female, Esophageal Squamous Cell Carcinoma, medicine.drug, Research Article, Nut, Clinical Oncology, Adult, medicine.medical_specialty, Dysplasia, Arecoline, Radiation Therapy, Surgical and Invasive Medical Procedures, Mouse Models, Antineoplastic Agents, Research and Analysis Methods, Carcinomas, 03 medical and health sciences, Cancer Chemotherapy, Digestive System Procedures, Model Organisms, Signs and Symptoms, Drug Therapy, Diagnostic Medicine, Internal medicine, Carcinoma, medicine, Chemotherapy, Animals, Humans, Aged, Retrospective Studies, Papillomas, business.industry, lcsh:R, Cancers and Neoplasms, Retrospective cohort study, medicine.disease, biology.organism_classification, Mice, Inbred C57BL, 030104 developmental biology, Concomitant, lcsh:Q, Clinical Medicine, business, Combination Chemotherapy
Abstract

OBJECTIVE:Areca nut chewing is carcinogenic to humans. However, little is known about the impact of areca nut chewing on esophageal squamous cell carcinoma (ESCC). METHODS:We retrospectively reviewed 286 ESCC patients who received surgery or preoperative chemoradiotherapy followed by surgery at our institution. Background characteristics including areca nut chewing history were analyzed. The 4-nitroquinoline 1-oxide (4-NQO)-induced murine ESCC model was used to test the impact of arecoline, a main constituent of areca nut, on ESCC. RESULTS:Compared to patients without areca nut chewing history, patients with areca nut chewing history had overall a younger age of onset (Mean age: 56.75 versus 52.68 yrs, P

Published
2017

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