1. Increased risk of Alzheimer’s disease among patients with age-related macular degeneration: A nationwide population-based study
- Author
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Hui Ju Lin, Kai-Chieh Hu, Peng-Tai Tien, Lei Wan, Li-Yen Wen, Chih Sheng Chen, Ming-Yen Wu, Jung-Nien Lai, Lu-Ting Chiu, and Jamie Jiin-Yi Chen
- Subjects
Male ,Eye Diseases ,Pulmonology ,Epidemiology ,Osteoporosis ,Disease ,Comorbidity ,Alzheimer's Disease ,Coronary artery disease ,Cohort Studies ,Macular Degeneration ,0302 clinical medicine ,Medical Conditions ,Endocrinology ,Risk Factors ,Medicine and Health Sciences ,Geriatric Ophthalmology ,Multidisciplinary ,Liver Diseases ,Retinal Degeneration ,Neurodegenerative Diseases ,Middle Aged ,Neurology ,Cirrhosis ,Cohort ,Medicine ,Retinal Disorders ,Female ,Research Article ,medicine.medical_specialty ,Endocrine Disorders ,Science ,Cerebrovascular Diseases ,Chronic Obstructive Pulmonary Disease ,Taiwan ,Gastroenterology and Hepatology ,03 medical and health sciences ,Alzheimer Disease ,Internal medicine ,Diabetes mellitus ,Mental Health and Psychiatry ,medicine ,Diabetes Mellitus ,Humans ,Aged ,Retrospective Studies ,business.industry ,Retrospective cohort study ,Macular degeneration ,medicine.disease ,Ophthalmology ,Geriatrics ,Macular Disorders ,Medical Risk Factors ,Metabolic Disorders ,030221 ophthalmology & optometry ,Dementia ,business ,030217 neurology & neurosurgery ,Kidney disease - Abstract
Objective This study aimed to investigate the risk of Alzheimer’s disease among patients with age-related macular degeneration and its association with confounding comorbidities. Method This was a population-based, retrospective cohort study. By accessing data from the National Health Insurance Research Database of Taiwan, we identified 10,578 patients aged 50–100 years who were newly diagnosed with age-related macular degeneration between 2000 and 2012 and 10,578 non- age-related macular degeneration individuals. The comorbidities assessed were osteoporosis, diabetes, cirrhosis, cerebrovascular disease, chronic kidney disease, hypertension, hyperlipidemia, coronary artery disease, and chronic obstructive pulmonary disease. Results Patients with age-related macular degeneration had a 1.23-fold increased risk of their condition advancing to Alzheimer’s disease (aHR = 1.23, 95% CI = 1.04–1.46). The younger patients were diagnosed with age-related macular degeneration, the more likely patients got Alzheimer’s disease (50–64 age group: aHR = 1.97, 95% CI = 1.04–3.73; 65–79 age group: aHR = 1.27, 95% CI = 1.02–1.58; 80–100 age group: aHR = 1.06, 95% CI = 0.78–1.45). In addition, there were significantly higher risks of Alzheimer’s disease for patients with cirrhosis (aHR = 1.50, 95% CI = 1.09–2.06) in the age-related macular degeneration cohort than in the non-age-related macular degeneration cohort. Conclusion Patients with age-related macular degeneration may exhibit a higher risk of Alzheimer’s disease than people without age-related macular degeneration.
- Published
- 2021