1. Identification of KIF3A as a Novel Candidate Gene for Childhood Asthma Using RNA Expression and Population Allelic Frequencies Differences
- Author
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Kovacic, Melinda Butsch, Myers, Jocelyn M Biagini, Wang, Ning, Martin, Lisa J, Lindsey, Mark, Ericksen, Mark B, He, Hua, Patterson, Tia L, Baye, Tesfaye M, Torgerson, Dara, Roth, Lindsey A, Gupta, Jayanta, Sivaprasad, Umasundari, Gibson, Aaron M, Tsoras, Anna M, Hu, Donglei, Eng, Celeste, Chapela, Rocío, Rodríguez-Santana, José R, Rodríguez-Cintrón, William, Avila, Pedro C, Beckman, Kenneth, Seibold, Max A, Gignoux, Chris, Musaad, Salma M, Chen, Weiguo, Burchard, Esteban González, and Hershey, Gurjit K Khurana
- Subjects
Biological Sciences ,Biomedical and Clinical Sciences ,Genetics ,Epidemiology ,Health Sciences ,Clinical Research ,Lung ,Asthma ,Aetiology ,2.1 Biological and endogenous factors ,Respiratory ,Adolescent ,Child ,Child ,Preschool ,Female ,Gene Expression Profiling ,Gene Frequency ,Humans ,Hypersensitivity ,Kinesins ,Male ,Polymorphism ,Single Nucleotide ,RNA ,Reproducibility of Results ,Kinesin ,General Science & Technology - Abstract
BackgroundAsthma is a chronic inflammatory disease with a strong genetic predisposition. A major challenge for candidate gene association studies in asthma is the selection of biologically relevant genes.Methodology/principal findingsUsing epithelial RNA expression arrays, HapMap allele frequency variation, and the literature, we identified six possible candidate susceptibility genes for childhood asthma including ADCY2, DNAH5, KIF3A, PDE4B, PLAU, SPRR2B. To evaluate these genes, we compared the genotypes of 194 predominantly tagging SNPs in 790 asthmatic, allergic and non-allergic children. We found that SNPs in all six genes were nominally associated with asthma (p
- Published
- 2011