1. Renal function is associated with one-month and one-year mortality in patients with intracerebral hemorrhage.
- Author
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Wang, I-Kuan, Yen, Tzung-Hai, Tsai, Chon-Haw, Sun, Yu, Chang, Wei-Lun, Chen, Po-Lin, Lai, Ta-Chang, Yeh, Po-Yen, Wei, Cheng-Yu, Lin, Cheng-Li, Hsu, Kai-Cheng, Li, Chi-Yuan, Sung, Fung-Chang, and Hsu, Chung Y.
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CEREBRAL hemorrhage ,KIDNEY physiology ,MORTALITY risk factors ,GLOMERULAR filtration rate ,STROKE - Abstract
Objective: This study evaluated short-term (1-month) and long-term (1-year) mortality risks associated with the glomerular filtration rate (eGFR) on admission for patients with intracerebral hemorrhage. Methods: From the Taiwan Stroke Registry data from April 2006 to December 2016, we identified and stratified patients with intracerebral hemorrhage into five subgroups by the eGFR level on admission: ≥90, 60–89, 30–59, 15–29, and <15 mL/min/1.73 m
2 or on dialysis. Risks for 1-month and 1-year mortality after intracerebral hemorrhage were compared by the eGFR levels. Results: Both the 1-month and 1-year mortality rates progressively increased with the decrease in eGFR levels. The 1-month mortality rate in patients with eGFR < 15 mL/min/1.73 m2 or on dialysis was approximately 5.5-fold greater than that in patients with eGFR ≥ 90 mL/min/1.73 m2 (8.31 versus 1.50 per 1000 person-days), with an adjusted hazard ratio (HR) of 4.59 [95% confidence interval (CI) = 2.71–7.78]. Similarly, the 1-year mortality in patients with eGFR < 15 mL/min/1.73 m2 or on dialysis was 7.5 times that in patients with eGFR ≥ 90 mL/min/1.73 m2 (2.34 versus 0.31 per 1000 person-days), with an adjusted HR of 4.54 (95% CI 2.95–6.98). Conclusion: Impairment of renal function is an independent risk factor for mortality in patients with intracerebral hemorrhage in a gradual way. The eGFR level is a prognostic indicator for patients with intracerebral hemorrhage. [ABSTRACT FROM AUTHOR]- Published
- 2023
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