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2 results on '"Camilla Sjögren"'

1. The Drosophila midkine/pleiotrophin homologues Miple1 and Miple2 affect adult lifespan but are dispensable for alk signaling during embryonic gut formation.

Author

Fredrik Hugosson, Camilla Sjögren, Anna Birve, Ludmilla Hedlund, Therese Eriksson, and Ruth H Palmer

Subjects
Medicine, Science
Abstract

Midkine (MDK) and Pleiotrophin (PTN) are small heparin-binding cytokines with closely related structures. The Drosophila genome harbours two genes encoding members of the MDK/PTN family of proteins, known as miple1 and miple2. We have investigated the role of Miple proteins in vivo, in particular with regard to their proposed role as ligands for the Alk receptor tyrosine kinase (RTK). Here we show that Miple proteins are neither required to drive Alk signaling during Drosophila embryogenesis, nor are they essential for development in the fruit fly. Additionally we show that neither MDK nor PTN can activate hALK in vivo when ectopically co-expressed in the fly. In conclusion, our data suggest that Alk is not activated by MDK/PTN related growth factors Miple1 and Miple 2 in vivo.

Published
2014
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2. The Drosophila midkine/pleiotrophin homologues Miple1 and Miple2 affect adult lifespan but are dispensable for alk signaling during embryonic gut formation

Author

Ludmilla Hedlund, Anna Birve, Camilla Sjögren, Fredrik Hugosson, Ruth H. Palmer, and Therese Eriksson

Subjects
Male, Mesoderm, lcsh:Medicine, Pleiotrophin, Biochemistry, Genetics, medicine, Animals, Drosophila Proteins, Humans, Anaplastic Lymphoma Kinase, lcsh:Science, Molecular Biology, Midkine, Multidisciplinary, biology, fungi, lcsh:R, Biochemistry and Molecular Biology, Organisms, Gene Expression Regulation, Developmental, Receptor Protein-Tyrosine Kinases, Biology and Life Sciences, Drosophila embryogenesis, Cell Biology, biology.organism_classification, Molecular biology, Phenotype, Cell biology, medicine.anatomical_structure, biology.protein, Cytokines, Drosophila, Female, lcsh:Q, Drosophila melanogaster, Signal transduction, Carrier Proteins, Biokemi och molekylärbiologi, Gene Deletion, Drosophila Protein, Signal Transduction, Research Article, Developmental Biology
Abstract

Midkine (MDK) and Pleiotrophin (PTN) are small heparin-binding cytokines with closely related structures. The Drosophila genome harbours two genes encoding members of the MDK/PTN family of proteins, known as miple1 and miple2. We have investigated the role of Miple proteins in vivo, in particular with regard to their proposed role as ligands for the Alk receptor tyrosine kinase (RTK). Here we show that Miple proteins are neither required to drive Alk signaling during Drosophila embryogenesis, nor are they essential for development in the fruit fly. Additionally we show that neither MDK nor PTN can activate hALK in vivo when ectopically co-expressed in the fly. In conclusion, our data suggest that Alk is not activated by MDK/PTN related growth factors Miple1 and Miple 2 in vivo.

Published
2014

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