1. Condyle modeling stability, craniofacial asymmetry and ACTN3 genotypes: Contribution to TMD prevalence in a cohort of dentofacial deformities
- Author
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Joël Ferri, Romain Nicot, Kay Chung, Gwénaël Raoul, Alexandre R. Vieira, James J. Sciote, Bodescot, Myriam, Department of Oral and Maxillofacial Surgery [Lille], Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Médicaments et biomatériaux à libération contrôlée: mécanismes et optimisation - Advanced Drug Delivery Systems - U 1008 (MBLC - ADDS), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Temple University [Philadelphia], Pennsylvania Commonwealth System of Higher Education (PCSHE), University of Pittsburgh (PITT), This work is supported by the National Institute of Dental & Craniofacial research through a grant to Dr. Sciote, Musculoskeletal Heritable Influences on Malocclusion - R21DE022427., and Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille)-Université de Lille
- Subjects
0301 basic medicine ,Male ,medicine.medical_treatment ,Single Nucleotide Polymorphisms ,Orthognathic surgery ,[SDV.BBM.BM] Life Sciences [q-bio]/Biochemistry, Molecular Biology/Molecular biology ,Orthognathic Surgical Procedures ,0302 clinical medicine ,Skeletal Joints ,Medicine and Health Sciences ,Actinin ,Pyrophosphatases ,Musculoskeletal System ,Orthodontics ,[SDV.MHEP.RSOA] Life Sciences [q-bio]/Human health and pathology/Rhumatology and musculoskeletal system ,Multidisciplinary ,Dentofacial Deformities ,Temporomandibular Joint Disorders ,Chin ,Models, Dental ,3. Good health ,Masticatory force ,medicine.anatomical_structure ,[SDV.MHEP.RSOA]Life Sciences [q-bio]/Human health and pathology/Rhumatology and musculoskeletal system ,Physical Sciences ,Medicine ,Female ,Anatomy ,Research Article ,Adult ,Science ,Geometry ,Pain ,Surgical and Invasive Medical Procedures ,Polymorphism, Single Nucleotide ,Condyle ,03 medical and health sciences ,Signs and Symptoms ,stomatognathic system ,medicine ,Genetics ,Humans ,Genetic Predisposition to Disease ,Skeleton ,Genetic Association Studies ,business.industry ,Phosphoric Diester Hydrolases ,Mandibular Condyle ,Asymmetry ,Biology and Life Sciences ,[SDV.BBM.BM]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Molecular biology ,030206 dentistry ,Myalgia ,medicine.disease ,Temporomandibular joint ,stomatognathic diseases ,030104 developmental biology ,Jaw ,[SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie ,Face ,[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie ,Craniofacial asymmetry ,Malocclusion ,Clinical Medicine ,business ,Head ,Mathematics - Abstract
International audience; Craniofacial asymmetry, mandibular condylar modeling and temporomandibular joint disorders are common comorbidities of skeletally disproportionate malocclusions, but etiology of occurrence together is poorly understood. We compared asymmetry, condyle modeling stability and temporomandibular health in a cohort of 128 patients having orthodontics and orthognathic surgery to correct dentofacial deformity malocclusions. We also compared ACTN3 and ENPP1 genotypes for association to clinical conditions. Pre-surgical posterior-anterior cephalometric and panometric radiographic analyses; jaw pain and function questionnaire and clinical examination of TMD; and SNP-genotype analysis from saliva samples were compared to assess interrelationships. Almost half had asymmetries in need of surgical correction, which could be subdivided into four distinct morphological patterns. Asymmetric condyle modeling between sides was significantly greater in craniofacial asymmetry, but most commonly had an unanticipated pattern. Often, longer or larger condyles occurred on the shorter mandibular ramus side. Subjects with longer ramus but dimensionally smaller condyles were more likely to have self-reported TMD symptoms (p = 0.023) and significantly greater clinical diagnosis of TMD (p = 0 .000001), with masticatory myalgia most prominent. Genotyping found two significant genotype associations for ACTN3 rs1671064 (Q523R missense) p = 0.02; rs678397 (intronic SNP) p = 0.04 and one significant allele association rs1815739 (R577X nonsense) p = 0.00. Skeletal asymmetry, unusual condyle modeling and TMD are common and interrelated components of many dentofacial deformities. Imbalanced musculoskeletal functional adaptations and genetic or epigenetic influences contribute to the etiology, and require further investigation.
- Published
- 2020