1. Acceleration of age-associated methylation patterns in HIV-1-infected adults.
- Author
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Rickabaugh, Tammy M, Baxter, Ruth M, Sehl, Mary, Sinsheimer, Janet S, Hultin, Patricia M, Hultin, Lance E, Quach, Austin, Martínez-Maza, Otoniel, Horvath, Steve, Vilain, Eric, and Jamieson, Beth D
- Subjects
Leukocytes ,Mononuclear ,Humans ,HIV Infections ,Age Factors ,DNA Methylation ,Epigenesis ,Genetic ,Aging ,Adult ,Middle Aged ,Male ,Young Adult ,Leukocytes ,Mononuclear ,Epigenesis ,Genetic ,General Science & Technology - Abstract
Patients with treated HIV-1-infection experience earlier occurrence of aging-associated diseases, raising speculation that HIV-1-infection, or antiretroviral treatment, may accelerate aging. We recently described an age-related co-methylation module comprised of hundreds of CpGs; however, it is unknown whether aging and HIV-1-infection exert negative health effects through similar, or disparate, mechanisms. We investigated whether HIV-1-infection would induce age-associated methylation changes. We evaluated DNA methylation levels at >450,000 CpG sites in peripheral blood mononuclear cells (PBMC) of young (20-35) and older (36-56) adults in two separate groups of participants. Each age group for each data set consisted of 12 HIV-1-infected and 12 age-matched HIV-1-uninfected samples for a total of 96 samples. The effects of age and HIV-1 infection on methylation at each CpG revealed a strong correlation of 0.49, p
- Published
- 2015