1. Ceramides in tracheal aspirates of preterm infants: Marker for bronchopulmonary dysplasia
- Author
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Irwin K M Reiss, Jeroen Tibboel, Mariëlle W. Pijnenburg, Johan C. de Jongste, Bas S P Bol, Janneke N. Samsom, Esther van Mastrigt, Martin Post, André A. Kroon, Salomé Zweekhorst, Joost van Rosmalen, Pediatrics, and Epidemiology
- Subjects
0301 basic medicine ,Male ,Critical Care and Emergency Medicine ,Pulmonology ,Physiology ,medicine.medical_treatment ,Surfactants ,lcsh:Medicine ,Apoptosis ,Gastroenterology ,chemistry.chemical_compound ,Families ,0302 clinical medicine ,Medicine and Health Sciences ,Intubation ,Birth Weight ,lcsh:Science ,Children ,Bronchopulmonary Dysplasia ,Multidisciplinary ,Cell Death ,Gestational age ,Animal Models ,Trachea ,Chemistry ,Physiological Parameters ,Experimental Organism Systems ,Cell Processes ,Physical Sciences ,Female ,Infants ,Infant, Premature ,Research Article ,Chemical Elements ,medicine.medical_specialty ,Ceramide ,Birth weight ,Materials Science ,Surgical and Invasive Medical Procedures ,Mouse Models ,Ceramides ,Research and Analysis Methods ,behavioral disciplines and activities ,03 medical and health sciences ,Model Organisms ,Respiratory Failure ,Internal medicine ,mental disorders ,medicine ,Humans ,Materials by Attribute ,Mechanical ventilation ,business.industry ,lcsh:R ,Body Weight ,Postmenstrual Age ,Infant, Newborn ,Biology and Life Sciences ,Cell Biology ,medicine.disease ,Oxygen ,030104 developmental biology ,030228 respiratory system ,Respiratory failure ,chemistry ,Bronchopulmonary dysplasia ,Age Groups ,People and Places ,lcsh:Q ,Population Groupings ,business ,Biomarkers - Abstract
Background In an experimental mouse model we showed that ceramides play a role in the pathogenesis of bronchopulmonary dysplasia (BPD) and are a potential target for therapeutic intervention. We investigated whether ceramides are detectable in tracheal aspirates (TAs) of preterm infants and differ between infants with or without BPD. Methods Infants born ≤ 32 weeks of gestational age in need of mechanical ventilation in the first week of life were included. TAs were obtained directly after intubation and at day 1, 3, 5, 7, and 14. Ceramide concentrations were measured by tandem mass spectrometry. At 36 weeks postmenstrual age BPD was defined as having had ≥ 28 days supplemental oxygen. Results 122 infants were included, of which 14 died and 41 developed BPD. All infants showed an increase in ceramides after the first day of intubation. The ceramide profile differed significantly between preterm infants who did and did not develop BPD. However, the ceramide profile had no additional predictive value for BPD development over GA at birth, birth weight and total days of mechanical ventilation. Conclusions Ceramides are measurable in TAs of preterm born infants and may be an early marker for BPD development.
- Published
- 2016