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1. Risk factors, predictions, and progression of acute kidney injury in hospitalized COVID-19 patients: An observational retrospective cohort study.

Author

Maryam N Naser, Rana Al-Ghatam, Abdulla H Darwish, Manaf M Alqahtani, Hajar A Alahmadi, Khalifa A Mohamed, Nahed K Hasan, and Nuria S Perez

Subjects
Medicine, Science
Abstract

ObjectivesStudies have shown that acute kidney injury (AKI) occurrence post SARS-CoV-2 infection is complex and has a poor prognosis. Therefore, more studies are needed to understand the rate and the predications of AKI involvement among hospitalized COVID-19 patients and AKI's impact on prognosis while under different types of medications.Patients and methodsThis study is a retrospective observational cohort study conducted at Bahrain Defence Force (BDF) Royal Medical Services. Medical records of COVID-19 patients admitted to BDF hospital, treated, and followed up from April 2020 to October 2020 were retrieved. Data were analyzed using univariate and multivariate logistic regression with covariate adjustment, and the odds ratio (OR) and 95% confidence (95% CI) interval were reported.ResultsAmong 353 patients admitted with COVID-19, 47.6% developed AKI. Overall, 51.8% of patients with AKI died compared to 2.2% of patients who did not develop AKI (p< 0.001 with OR 48.6 and 95% CI 17.2-136.9). Besides, deaths in patients classified with AKI staging were positively correlated and multivariate regression analysis revealed that moderate to severe hypoalbuminemia (ConclusionsThe incidence of AKI in hospitalized COVID-19 patients and the mortality rate among AKI patients were high and correlated with AKI staging. Furthermore, laboratory testing for serum albumin, hypercoagulability and cardiac injury markers maybe indicative for AKI development. Therefore, clinicians should be mandated to perform such tests on admission and follow-up in hospitalized patients.

Published
2021
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2. Risk factors, predictions, and progression of acute kidney injury in hospitalized COVID-19 patients: An observational retrospective cohort study

Author

Manaf M. Alqahtani, Nahed K. Hasan, Hajar A. Alahmadi, Nuria S. Perez, Khalifa A. Mohamed, Abdulla H. Darwish, Maryam N. Naser, and Rana Al-Ghatam

Subjects
Male, RNA viruses, Viral Diseases, Coronaviruses, Comorbidity, urologic and male genital diseases, Biochemistry, Cohort Studies, Geographical Locations, Medical Conditions, Endocrinology, Risk Factors, Medicine and Health Sciences, Hypoalbuminemia, Hospital Mortality, Pathology and laboratory medicine, Multidisciplinary, Incidence (epidemiology), Mortality rate, Incidence, Acute kidney injury, Acute Kidney Injury, Middle Aged, Medical microbiology, Prognosis, female genital diseases and pregnancy complications, Hospitals, Troponin, Hospitalization, Intensive Care Units, Infectious Diseases, Creatinine, Bahrain, Viruses, Medicine, Female, Anatomy, SARS CoV 2, Pathogens, Cohort study, Research Article, Adult, medicine.medical_specialty, Asia, SARS coronavirus, Endocrine Disorders, Science, Microbiology, Internal medicine, Albumins, medicine, Diabetes Mellitus, Humans, Serum Albumin, Aged, Retrospective Studies, business.industry, SARS-CoV-2, Organisms, Viral pathogens, COVID-19, Biology and Life Sciences, Proteins, Retrospective cohort study, Covid 19, Kidneys, Odds ratio, Renal System, medicine.disease, Respiration, Artificial, Microbial pathogens, Cytoskeletal Proteins, Metabolic Disorders, People and Places, business, Biomarkers
Abstract

ObjectivesStudies have shown that acute kidney injury (AKI) occurrence post SARS-CoV-2 infection is complex and has a poor prognosis. Therefore, more studies are needed to understand the rate and the predications of AKI involvement among hospitalized COVID-19 patients and AKI’s impact on prognosis while under different types of medications.Patients and methodsThis study is a retrospective observational cohort study conducted at Bahrain Defence Force (BDF) Royal Medical Services. Medical records of COVID-19 patients admitted to BDF hospital, treated, and followed up from April 2020 to October 2020 were retrieved. Data were analyzed using univariate and multivariate logistic regression with covariate adjustment, and the odds ratio (OR) and 95% confidence (95% CI) interval were reported.ResultsAmong 353 patients admitted with COVID-19, 47.6% developed AKI. Overall, 51.8% of patients with AKI died compared to 2.2% of patients who did not develop AKI (p< 0.001 with OR 48.6 and 95% CI 17.2–136.9). Besides, deaths in patients classified with AKI staging were positively correlated and multivariate regression analysis revealed that moderate to severe hypoalbuminemia (ConclusionsThe incidence of AKI in hospitalized COVID-19 patients and the mortality rate among AKI patients were high and correlated with AKI staging. Furthermore, laboratory testing for serum albumin, hypercoagulability and cardiac injury markers maybe indicative for AKI development. Therefore, clinicians should be mandated to perform such tests on admission and follow-up in hospitalized patients.

Published
2021

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