1. The Prevalence of Mild Cognitive Impairment in Diverse Geographical and Ethnocultural Regions: The COSMIC Collaboration
- Author
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Sachdev, P.S., Lipnicki, D.M., Kochan, N.A., Crawford, J.D., Thalamuthu, A., Andrews, G., Brayne, C., Matthews, F.E., Stephan, B.C.M., Lipton, R.B., Katz, M.J., Ritchie, K., Carrière, I., Ancelin, M.L, Lam, L.C.W., Wong, C.H.Y., Fung, A.W.T., Guaita, A., Vaccaro, R., Davin, A., Ganguli, M., Dodge, H., Hughes, T., Anstey, K.J., Cherbuin, N., Butterworth, P., Ng, T.P., Gao, Q., Reppermund, S., Brodaty, H., Schupf, N., Manly, J., Stern, Y., Lobo, A., Lopez-Anton, R., Santabárbara, J., Zimmerman, M., Derby, C., Leung, G.T.Y., Chan, W.C., Polito, L., Abbondanza, S., Valle, E., Colombo, M., Vitali, S.F., Fossi, S., Zaccaria, D., Forloni, G., Villani, S., Christensen, H., MacKinnon, A., Easteal, S., Jacomb, T., Maxwell, K., Bowman, A., Burns, K., Broe, A., Dekker, J., Dooley, L., De Permentier, M., Fairjones, S., Fletcher, J., French, T., Foster, C., Nugent-Cleary-Fox, E., Gooi, C., Harvey, E., Helyer, R., Hsieh, S., Hughes, L., Jacek, S., Johnston, M., McCade, D., Meeth, S., Milne, E., Moir, A., O'Grady, R., Pfaeffli, K., Pose, C., Reuser, L., Rose, A., Schofield, P., Shahnawaz, Z., Sharpley, A., Thompson, C., Queisser, W., Wong, S., Mayeux, R., Brickman, A., Luchsinger, J., Sanchez, D., Tang, M.X., Andrews, H., Marcos, G., De-La-Cámara, C., Saz, P., Ventura, T., Quintanilla, M.A., Lobo, E., University of South Wales (USW), University of Cambridge [UK] (CAM), Newcastle University [Newcastle], Albert Einstein College of Medicine [New York], Neuropsychiatrie : recherche épidémiologique et clinique (PSNREC), Université Montpellier 1 (UM1)-Université de Montpellier (UM)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Imperial College London, The Chinese University of Hong Kong [Hong Kong], Tai Po Hospital, University of Pittsburgh School of Medicine, Pennsylvania Commonwealth System of Higher Education (PCSHE), Department of Neurology, Oregon Health and Science University [Portland] (OHSU), University of Michigan [Ann Arbor], University of Michigan System, Australian National University (ANU), National University of Singapore (NUS), University of New South Wales [Sydney] (UNSW), Columbia University [New York], Centro de Investigación Biomédica en Red Salud Mental [Madrid] (CIBER-SAM), University of Zaragoza - Universidad de Zaragoza [Zaragoza], and Université Montpellier 1 (UM1)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)
- Subjects
Gerontology ,Male ,medicine.medical_specialty ,Asia ,Epidemiology ,Cross-sectional study ,Clinical Dementia Rating ,lcsh:Medicine ,Neuropsychological Tests ,Prevalence ,Medicine ,Dementia ,Humans ,Cognitive Dysfunction ,Longitudinal Studies ,Cooperative Behavior ,lcsh:Science ,Cognitive impairment ,Aged ,Aged, 80 and over ,Multidisciplinary ,business.industry ,FOS: Clinical medicine ,lcsh:R ,Neurosciences ,Australia ,Mild cognitive impairment ,Cognition ,Middle Aged ,medicine.disease ,Europe ,Cross-Sectional Studies ,Disease Progression ,lcsh:Q ,Mental health ,[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie ,Female ,Cooperative behavior ,Alzheimer's disease ,business ,Demography - Abstract
International audience; BACKGROUND : Changes in criteria and differences in populations studied and methodology have produced a wide range of prevalence estimates for mild cognitive impairment (MCI).METHODS : Uniform criteria were applied to harmonized data from 11 studies from USA, Europe, Asia and Australia, and MCI prevalence estimates determined using three separate definitions of cognitive impairment.RESULTS : The published range of MCI prevalence estimates was 5.0%-36.7%. This was reduced with all cognitive impairment definitions: performance in the bottom 6.681% (3.2%-10.8%); Clinical Dementia Rating of 0.5 (1.8%-14.9%); Mini-Mental State Examination score of 24-27 (2.1%-20.7%). Prevalences using the first definition were 5.9% overall, and increased with age (P < .001) but were unaffected by sex or the main races/ethnicities investigated (Whites and Chinese). Not completing high school increased the likelihood of MCI (P ≤ .01).CONCLUSION : Applying uniform criteria to harmonized data greatly reduced the variation in MCI prevalence internationally.
- Published
- 2015