1. Expression levels of cleaved caspase-3 and caspase-3 in tumorigenesis and prognosis of oral tongue squamous cell carcinoma
- Author
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Ting-Ying Fu, Pi-Chuang Wu, Yu-Kai Tseng, Chih-Wen Shu, Bor-Hwang Kang, Pei-Feng Liu, Luo-Ping Ger, Yu-Chang Hu, Chi-Chuang Liang, I-Chien Hsieh, Huei-Han Liou, and Yu-Yi Hou
- Subjects
Male ,0301 basic medicine ,Oncology ,Carcinogenesis ,Colorectal cancer ,lcsh:Medicine ,Apoptosis ,Pathology and Laboratory Medicine ,medicine.disease_cause ,Cytopathology ,Prostate cancer ,0302 clinical medicine ,Medicine and Health Sciences ,lcsh:Science ,Lymph node ,Caspase 8 ,Multidisciplinary ,Tissue microarray ,Cell Death ,Caspase 3 ,Cell Differentiation ,Middle Aged ,Prognosis ,Caspase 9 ,Tongue Neoplasms ,medicine.anatomical_structure ,Cell Processes ,030220 oncology & carcinogenesis ,Carcinoma, Squamous Cell ,Immunohistochemistry ,Female ,Anatomy ,Research Article ,Adult ,medicine.medical_specialty ,Research and Analysis Methods ,Disease-Free Survival ,Lymphatic System ,03 medical and health sciences ,Diagnostic Medicine ,Internal medicine ,medicine ,Carcinoma ,Humans ,Differentiated Tumors ,Immunohistochemistry Techniques ,business.industry ,lcsh:R ,Biology and Life Sciences ,Cancers and Neoplasms ,Cancer ,Cell Biology ,medicine.disease ,Histochemistry and Cytochemistry Techniques ,030104 developmental biology ,Anatomical Pathology ,Immunologic Techniques ,Cancer research ,lcsh:Q ,Lymph Nodes ,business ,Developmental Biology - Abstract
Apoptosis plays a dual role in cancer development and malignancy. The role of apoptosis-related caspases in cancer remains controversial, particularly in oral tongue squamous cell carcinoma (OTSCC). In this study, we examined the protein levels of cleaved caspase-3, caspase-3, caspase-8, and caspase-9 on tissue microarrays consisting of samples from 246 OTSCC patients by immunohistochemistry. Wilcoxon signed-rank test indicated that the protein levels of cleaved caspase-3, caspase-3, caspase-8, and caspase-9 in tumor tissues were significantly higher compared to those in adjacent normal tissues (all p
- Published
- 2017