1. Transcriptome analysis of immune genes in peripheral blood mononuclear cells of young foals and adult horses
- Author
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Rebecca L. Tallmadge, Minghui Wang, Maria Julia B. Felippe, and Qi Sun
- Subjects
0301 basic medicine ,Chemokine ,B Cells ,lcsh:Medicine ,Gene Expression ,Complement receptor ,Immune Receptors ,Biochemistry ,White Blood Cells ,0302 clinical medicine ,Animal Cells ,Medicine and Health Sciences ,lcsh:Science ,Receptor ,Toll-like Receptors ,Mammals ,Immunity, Cellular ,Multidisciplinary ,Immune System Proteins ,T Cells ,Eukaryota ,Genomics ,medicine.anatomical_structure ,Vertebrates ,Cellular Types ,Transcriptome Analysis ,Research Article ,Signal Transduction ,Immune Cells ,Equines ,Immunology ,Biology ,Natural killer cell ,03 medical and health sciences ,Immune system ,medicine ,Genetics ,Animals ,Horses ,Antibody-Producing Cells ,B cell ,Innate immune system ,Blood Cells ,Gene Expression Profiling ,lcsh:R ,Organisms ,Biology and Life Sciences ,Proteins ,Computational Biology ,Cell Biology ,Genome Analysis ,T Cell Receptors ,030104 developmental biology ,Immune System ,TLR3 ,Amniotes ,biology.protein ,Leukocytes, Mononuclear ,lcsh:Q ,030215 immunology - Abstract
During the neonatal period, the ability to generate immune effector and memory responses to vaccines or pathogens is often questioned. This study was undertaken to obtain a global view of the natural differences in the expression of immune genes early in life. Our hypothesis was that transcriptome analyses of peripheral blood mononuclear cells (PBMCs) of foals (on day 1 and day 42 after birth) and adult horses would show differential gene expression profiles that characterize natural immune processes. Gene ontology enrichment analysis provided assessment of biological processes affected by age, and a list of 897 genes with ≥2 fold higher (p
- Published
- 2017