1. Plasma gelsolin is associated with hip BMD in Chinese postmenopausal women
- Author
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Long-Fei Wu, Ju Shi, Xing-Bo Mo, Hong Zhu, Fei-Yan Deng, Xu Zhou, Yonghong Zhang, Bing Ge, Shu-Feng Lei, Wen-Yu Wang, Dong-Cheng Zhu, and Chang-Hua Tang
- Subjects
0301 basic medicine ,Bone density ,Physiology ,Osteoporosis ,lcsh:Medicine ,Osteoclasts ,Biochemistry ,0302 clinical medicine ,Bone Density ,Animal Cells ,Medicine and Health Sciences ,Ethnicities ,lcsh:Science ,Connective Tissue Diseases ,Musculoskeletal System ,Osteoporosis, Postmenopausal ,Connective Tissue Cells ,Sampling scheme ,Multidisciplinary ,Body Fluids ,medicine.anatomical_structure ,Blood ,Connective Tissue ,Hip bone ,Biomarker (medicine) ,Female ,Bone Remodeling ,Anatomy ,Cellular Types ,Research Article ,musculoskeletal diseases ,medicine.medical_specialty ,China ,Blood Plasma ,Pelvis ,03 medical and health sciences ,Rheumatology ,Internal medicine ,medicine ,Humans ,Bone Resorption ,Bone ,Pelvic Bones ,Gelsolin ,Aged ,Postmenopausal women ,Hip ,business.industry ,lcsh:R ,Biology and Life Sciences ,Cell Biology ,medicine.disease ,030104 developmental biology ,Endocrinology ,Mineral density ,Biological Tissue ,People and Places ,lcsh:Q ,Population Groupings ,business ,Physiological Processes ,Chinese People ,030217 neurology & neurosurgery ,Biomarkers - Abstract
Gelsolin (GSN) protein, expressed in circulating monocytes, was previously reported to be associated with osteoporosis in both Chinese and Caucasian women. This study aims to test if plasma GSN protein level is associated with hip bone mineral density (BMD) in Chinese population. Based on two study Groups containing 6,308 old Chinese, we adopted extreme sampling scheme and selected 3 independent samples (Subgroups 1-3) for discovery, replication, and validation purposes. We tested plasma GSN concentration, and analyzed whether plasma GSN level differs between subjects with extremely low vs. high hip BMD. In Group 1 (N = 1,860), the plasma GSN level increased in the female with low BMD, which was discovered in the Subgroup 1 (N = 42, p = 0.093) and replicated in the Subgroup 2 (N = 39, p = 0.095). With more extreme sampling for the Subgroup 3 from the Group 2 (N = 4,448), the difference of plasma GSN level in the female with low BMD vs. high BMD is more significant (N = 45, p = 0.037). After the subjects were pooled from Subgroups 2 and 3, the difference in plasma GSN between low and high BMD subjects became even more significant (p = 0.016). The plasma GSN level was negatively correlated with total hip BMD (r = -0.26, p = 0.033). We concluded that plasma GSN was associated with hip BMD in Chinese postmenopausal women and plasma GSN might be a potential risk biomarker for osteoporosis.
- Published
- 2018