1. Genome-wide association study between CNVs and milk production traits in Valle del Belice sheep
- Author
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Baldassare Portolano, Alessandro Bagnato, Anna Maria Sutera, Maria Teresa Sardina, Gianluca Sottile, Marco Tolone, Maria Giuseppina Strillacci, Salvatore Mastrangelo, Rosalia Di Gerlando, Di Gerlando, Rosalia, Sutera, Anna Maria, Mastrangelo, Salvatore, Tolone, Marco, Portolano, Baldassare, Sottile, Gianluca, Bagnato, Alessandro, Strillacci, Maria Giuseppina, and Sardina, Maria Teresa
- Subjects
0301 basic medicine ,False discovery rate ,Candidate gene ,DNA Copy Number Variations ,Genotype ,Science ,Population ,Genomic Structural Variation ,Quantitative Trait Loci ,Genome-wide association study ,Quantitative trait locus ,Biology ,03 medical and health sciences ,Settore AGR/17 - Zootecnica Generale E Miglioramento Genetico ,Animals ,Lactation ,Copy-number variation ,education ,Gene ,Genetics ,education.field_of_study ,Multidisciplinary ,Sheep ,Biochemistry, Genetics and Molecular Biology (all) ,Animals, chromosome mapping, dairying, female, genome-Wide association study, genotype, lactation, sheep, DNA copy number variations, quantitative trait loci ,0402 animal and dairy science ,Chromosome Mapping ,04 agricultural and veterinary sciences ,040201 dairy & animal science ,Dairying ,030104 developmental biology ,Agricultural and Biological Sciences (all) ,Medicine ,Female ,Genome-Wide Association Study ,Research Article - Abstract
Copy number variation (CNV) is a major source of genomic structural variation. The aim of this study was to detect genomic CNV regions (CNVR) in Valle del Belice dairy sheep population and to identify those affecting milk production traits. The GO analysis identified possible candidate genes and pathways related to the selected traits. We identified CNVs in 416 individuals genotyped using the Illumina OvineSNP50 BeadChip array. The CNV association using a correlation-trend test model was examined with the Golden Helix SVS 8.7.0 tool. Significant CNVs were detected when their adjusted p-value was
- Published
- 2019