1,705 results on '"Chen Y"'
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2. Elevated hydrostatic pressure disturbs expression of growth factors in human renal epithelial cells.
- Author
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Chen Yan, Jie Xiao, Yong-Hua Peng, and Tao-Sheng Li
- Subjects
Medicine ,Science - Abstract
Obstructive uropathy is a common kidney disease caused by elevated hydrostatic pressure (HP), but relevant molecular and cellular mechanisms have not yet been well understood. In this study, we ex vivo investigated the effects of elevated HP on human renal epithelial cells (HREpCs). Primary HREpCs were subjected to 100 cmH2O HP for 8 or 48 h. Then, the cells were cultured without HP stimulation for another 24 h or 72 h. Cell morphology showed almost no change after 8h HP treatment, but exhibited reversible elongation after 48h HP treatment. HP treatment for 8 h increased the expression of TGFB1 and VEGFA but decreased the expression of CSF2 and TGFB2. On the other hand, HP treatment for 48 h downregulated the expression of CSF2, TGFB2, PDGFB, VEGFA, and VEGFB, while upregulated the expression of TGFB3. Interestingly, all changes induced by 48 h HP treatment were detected more severe compared to 8 h HP treatment. In conclusion, elongated ex vivo HP loading to renal epithelial cells induces reversible changes on cell morphology and disturbs the expression of several growth factors, which provides novel mechanistic insight on elevated HP-caused kidney injury such as obstructive uropathy.
- Published
- 2024
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3. An untargeted comparative metabolomics analysis of infants with and without late-onset breast milk jaundice.
- Author
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Mingxuan Cui, Qianying Guo, Shilong Zhao, Xinran Liu, Chen Yang, Peng Liu, and Linlin Wang
- Subjects
Medicine ,Science - Abstract
BackgroundLate-onset breast milk jaundice (LBMJ) is a common form of hyperbilirubinemia, which can result in serious complications for newborns with persistently high bilirubin levels. The aim of this study was to investigate the differences in fecal metabolites between breastfed infants with and without LBMJ in order to elucidate potential biological mechanisms.MethodsBiological samples were collected from 12 infants with LBMJ and 12 healthy individuals. Ultra-high performance liquid chromatography quadrupole time-of-flight tandem mass spectrometry (UHPLC-Q-TOF/MS) was utilized for non-targeted determination of fecal metabolites. Principal components analysis (PCA), cluster analysis, and differential metabolite analysis were performed in both positive ion mode and negative ion mode for the two groups. Additionally, the KEGG database was employed to comprehensively analyze the pathways of differential metabolites.ResultsThere were no significant differences in maternal and neonatal demographic characteristics between the two groups (p > 0.05). The results of PCA and cluster heat map analysis in both modes showed that there were significant differences in metabolites between the two groups. Among 751 differential metabolites (DMs) detected in positive ion mode, 720 were up-regulated in the case group while 31 were down-regulated. In negative ion mode, 1891 DMs were detected, including 817 up-regulated metabolites and 1074 down-regulated metabolites in the case group. Analysis of differential metabolic pathways showed that the DMs of the two groups were mainly annotated and enriched in Biotin metabolism, N-Glycan biosynthesis, Taurine and hypotaurine metabolism, Pyrimidine metabolism, and Pentose and glucuronate interconversions.ConclusionSignificant differences exist in fecal metabolites between LBMJ infants and healthy controls. The study of differential metabolic pathways provides insights into the mechanism of LBMJ.
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- 2024
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4. Analytical solution of fuzzy heat problem in two-dimensional case under Caputo-type fractional derivative.
- Author
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Muhammad Nadeem, Chen Yilin, Devendra Kumar, and Yahya Alsayyad
- Subjects
Medicine ,Science - Abstract
This work aims to investigate the analytical solution of a two-dimensional fuzzy fractional-ordered heat equation that includes an external diffusion source factor. We develop the Sawi homotopy perturbation transform scheme (SHPTS) by merging the Sawi transform and the homotopy perturbation scheme. The fractional derivatives are examined in Caputo sense. The novelty and innovation of this study originate from the fact that this technique has never been tested for two-dimensional fuzzy fractional ordered heat problems. We presented two distinguished examples to validate our scheme, and the solutions are in fuzzy form. We also exhibit contour and surface plots for the lower and upper bound solutions of two-dimensional fuzzy fractional-ordered heat problems. The results show that this approach works quite well for resolving fuzzy fractional situations.
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- 2024
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5. Hydrostatic pressure mediates epithelial-mesenchymal transition of cholangiocytes through RhoA/ROCK and TGF-β/smad pathways.
- Author
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Mahmoud Osman Khalifa, Chen Yan, Yong Chai, Kosei Ito, Shou-Hua Zhang, and Tao-Sheng Li
- Subjects
Medicine ,Science - Abstract
Biomechanical cue within the tissue microenvironment is known to play a critical role in regulating cell behaviors and maintaining tissue homeostasis. As hydrostatic pressure often increases in biliary system under pathological states, we investigated the effect of the moderate elevation of the hydrostatic pressure on biliary epithelial cells, especially on the epithelial-mesenchymal transition (EMT). Human intrahepatic biliary epithelial cells were loaded to hydrostatic pressure using a commercial device. We found that loading the cells to 50 mmHg hydrostatic pressure induced obvious morphological changes and significantly upregulated vimentin, ZEB1, and pSmad2/3, fibronectin, and collagen 1α. All changes induced by hydrostatic pressure loading were effectively mitigated by either ROCK inhibitor (Y-27632) or ALK5 inhibitor (SB-431542). Our in vitro experimental data suggests that hydrostatic pressure loading induces EMT of cholangiocytes through RhoA/ROCK and TGF-β/Smad pathways. Elevated hydrostatic pressure in biliary duct system under pathological states may promote the biliary epithelial cells shifting to profibrotic and mesenchymal characteristics.
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- 2024
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6. Quality of Vitamin K Antagonist Control and 1-Year Outcomes in Patients with Atrial Fibrillation: A Global Perspective from the GARFIELD-AF Registry
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Faria Neto, J., Steffens, A., Yim, K. H., Yoo, K. M., Yoon, E. J., Yun, S. Y., Angchaisuksiri, P., Chawanadelert, S., Mongkolwongroj, P., Kanokphatcharakun, K., Cheewatanakornkul, S., Laksomya, T., Pattanaprichakul, S., Chantrarat, T., Rungaramsin, S., Silaruks, S., Wongcharoen, W., Siriwattana, K., Likittanasombat, K., Katekangplu, P., Boonyapisit, W., Cholsaringkarl, D., Chatlaong, B., Chattranukulchai, P., Santanakorn, Y., Hutayanon, P., Khunrong, P., Bunyapipat, T., Jai-Aue, S., Kaewsuwanna, P., Bamungpong, P., Gunaparn, S., Hongsuppinyo, S., Inphontan, R., Khattaroek, R., Khunkong, K., Kitmapawanont, U., Kongsin, C., Naratreekoon, B., Ninwaranon, S., Phangyota, J., Phrommintikul, A., Phunpinyosak, P., Pongmorakot, K., Poomiphol, S., Pornnimitthum, N., Pumprueg, S., Ratchasikaew, S., Sanit, K., Sawanyawisuth, K., Silaruks, B., Sirichai, R., Sriwichian, A., Suebjaksing, W., Sukklad, P., Suttana, T., Vensentini, N., Ingaramo, A. C., Sambadaro, G. A., Fernandez Caputi, V, Berman, S. G., Dragotto, P., Kleiban, A. J., Centurion, N., Giacomi, G., Ahuad Guerrero, R. A., Conde, D., Zapata, G., Di Paola, L. A., Ramos, J. L., Dran, R. D., Egido, J., Fernandez, A. A., Fosco, M. J., Sassone, S., Sinisi, V. A., Cartasegna, L. R., Berli, M. A., Gomez Vilamajo, O. A., Ferroni, F., Alaguibe, E. D., Alvarez D'Amelio, A., Arabetti, C., Arias, L., Belardi, J. A., Bergesio, L., Berli, F., Berli, M., Borchowiec, S., Buzzetti, C., Cabrini, R., Campisi, V, Cappi, A. L., Carrizo, R., Colombo Berra, F., Costabel, J. P., Costamagna, O. J. A., Damonte, A. A., De Urquiza, I. N., Diez, F., Eden, M. F., Fanuele, M., Fernandez Voena, F., Foa Torres, M., Funosas, C., Giacomi, M. P., Gimenez, C. H., Gurfinkel, E. P., Had, M. de L. M., Hansen, V, Hrabar, A. D., Ingratta, M., Lopez, A., Maehara, G., Maffei, L., Martinelli, A., Martinelli, C., Matkovich, J., Mautner, B., Meirino, A., Munguia, R., Navarro, A., Novas, V, Perez Prados, G., Pontoriero, J., Potito, R. N., Ricotti, C., Rodriguez, M. A., Mairesse, G., Boussy, T., Godart, P., De Wolf, A., Voet, J., Heyse, A., Hollanders, G., Ann, W., Vercammen, J., Purnode, P., Blankoff, I, Faes, D., Balthazar, Y., Beutels, M., Marechal, P., Verstraete, S., Xhaet, O., Striekwold, H., Thoeng, J., Hermans, K., Alzand, B., Ascoop, A-K, Banaeian, F., Barbuto, A-M, Billiaux, A. C., Blockmans, M., Bouvy, C., Brike, C., Capiau, H., Casier, T., Conde Y Bolado, A., De Cleen, D., De Coninck, M., de Vos, M., de Weerdt, N., Delforge, M., Delvigne, M., Denie, D., Derycker, K., Deweerd, E., Dormal, F., Drieghe, S., Everaert, M., Eykerman, T., Feys, E., Ghekiere, M., Gits, F., Hellemans, S., Helvasto, L., Jacobs, C., Lips, S., Mestdagh, I, Nimmegeers, J., Piamonte, V, Pollet, P., Postolache, A., Raepers, M., Raymenants, E., Richa, J., Rombouts, H., Salembier, J., Scheurwegs, C., Semeraro, O., Simons, N., Smessaert, C., Smolders, W., Stockman, I, Tahon, S., Thyssen, V, Tincani, G., Van Durme, F., Van Lier, D., Vandekerckhove, H., Vandekerckhove, Y., Vandenbroeck, D., Vandorpe, A., Vanhalst, E., Vanhauwaert, B., Vantomme, C., Vergauwen, L., Verloove, H., Vydt, T., Weyn, T., Jansky, P., Reichert, P., Spacek, R., Machova, V, Zidkova, E., Ludka, O., Olsr, J., Kotik, L., Plocova, K., Racz, B., Ferkl, R., Hubac, J., Kotik, I, Monhart, Z., Burianova, H., Jerabek, O., Pisova, J., Petrova, I, Dedek, V, Honkova, M., Podrazil, P., Spinar, J., Vitovec, J., Novak, M., Lastuvka, J., Durdil, V, Antonova, P., Bockova, L., Bultas, J., Chlumsky, J., Dastychova, L., Drasnar, T., Honek, J., Horejsi, M., Hubacova, V, Janska, L., Kopeckova, I, Kratochvilova, R., Krcova, E., Labrova, R., Lindourkova, A., Lipoldova, J., Lubanda, H., Ludkova, A., Mahdalikova, L., Majernikova, M., Michalik, D., Potuznik, P., Prochazkova, E., Sulc, A., Sveceny, J., Valtova, M., Zidek, M., D'Avino, M., Bongiorni, M. G., Severi, S., Capucci, A., Lodigiani, C., Salomone, E., Serviddio, G., Tondo, C., Golino, P., Mazzone, C., Iacopino, S., Pengo, V, Galvani, M., Moretti, L., Ambrosino, P., Banfi, E., Biagioli, V, Bianchi, A., Boggian, G., Breschi, M., Brusorio, S., Calcagnoli, F., Campagna, G., Carpenedo, M., Ciabatta, C., Ciliberti, G., Cimmino, G., D'Arienzo, C., Di Gennaro, L., Fedele, M., Ferrini, P. M., Granzow, K., Guazzaloca, G., Guerra, F., Lo Buglio, A., Longo, S., Macellari, F., Mesolella, E., Rolandi, F., Said Palladino, M. E., Salinger, M., Sanziani, L. S., Schygiel, P. O., Sossich, A., Tinto, J. F., Tonelli, L., Tufare, A. L., Vallejo, M., Yunis, M. E., Zillo, M., Zurbrigk, F. J., Barretto, A. C. P., Sobral Filho, D. C., Jaber, J., Armaganijan, D., Kakkar, Ajay K., Worthy, V, Verdi, C., Tripti, T., Treasure, L., Thompson, N., Theobald, H., Thatcher, A., Stephanie, B., Smith, K., Shoemaker, J., Shaw, P., Sanghera, T., Sage, A., Robertson, C., Richardson, T., Richard, C., Raziano, S., Raynor, J., Purcell, T., Pickelsimer, N., Peterson, J., Pearl, G., Paserchia, S., Parrott, T., Parker, M., Palumbo, V, Orosco, C., Minardo, J., Merritt, D., Merliss, A., Malone, E., Lincoln, T., Lee, J. A., Lay, M., Langdon, J., Knowles, P., Kerr, J., Keeling, M., Karl, S., Jones, P., Jones, L., Jones, A., Jasinski, S., Hicks, T., Hawkins, B., Hartranft, E., Harbour, T., Hakimi, F., Haideri, A., Gentry, P., Fielder, D., Ferdinand, K., Felpel, S., Evans, L., Eley, M., Dickerson, A., DePauw, J., Congal, S., Cervellione, K., Cassidy, D., Canova, M., Cameron-Watts, J., Browne, A., Brown, A., Bowers, S., Bentley, M., Bartlett, M., Ball, K., Asafu-Adjaye, N., Treasure, C., Nishijima, D., Pitta, S., Duffy, P., Noveck, H., Ison, R., Alberts, M., Remmel, K., Theodoro, D., Diercks, D., Delafontaine, P., Ahmed, W., Reddy, R., Haque, I, Gutowski, T., Alfieri, A., Beach, S., Miller, S., Williams, M., Mendelson, R., Falkowski, S., Franco, M., Cox, M., Kutayli, W. M., Ferrick, K., Quick, A., Wilson, V, Mullen, P., Garcia, J., Blumberg, E., Rama, P., Canosa, R., Goldhaber, S. Z., Thanzeel, M., Sharma, R., Sharma, N., Mohamed, R., Maqsood, I, Makdad, M., Magdaluyo, K., Jadhav, S., Haridas, P., El Bardisy, S., Al Mulla, A., Abdul, A., Subbaraman, B., Khan, M., Gupta, R., Wassef, A., Bazargani, N., Maruthanayagam, R., Al Naeemi, A., Al Omairi, M., Abu-Mahfouz, M., Naguib, A., Singh, R., Esheiba, E. M., Ibrahim, M., Nathani, M., Agrawal, A., Yousef, G., Al Mahmeed, W., van Zyl, F., Tau, T., Tarr, G., Smith, L., Skein, A., Shaik, F., Sasto, J., Salie, M., Rikhotso, L., Page, A., Mostert, M., Mavhusa, L., Marks, J., Loyd, E., Karsten, M., Henley, L., Ellis, T., Du Plessis, G., de Meyer, L., Davids, A., Conway, G., Chami, C., Cassimjee, S., Cannon, C., Boshoff, C., Booysen, M., Bester, C., Angel, G., Oosthuysen, W., Maharajh, S., Ramdass, A., Engelbrecht, J., Ahmed, F., Ismail, S., Loghdey, R., Ueckermann, V, Mntla, P., Greyling, D., Louw, R., Murray, A., Theron, H., van Zyl, L., Guerra, M., Pillay, T., Garda, R., Kelfkens, Y., Horak, A., Siebert, H., Bayat, J., Kettles, D., Zaatout, E., Tawfik, M., Taha, N., Soliman, A., Sobhy, M., Setiha, M., Samir, S., Sami, N., Salem, H., Reda, M., Reda, A., Ohanissian, A., Nawar, M., Mowafy, A., Khairy, T., Katta, A., Elkhadem, M., El-Etreby, A., Elbahry, A., El Etriby, S., El Din, M. G., Abou Seif, S. K., Abd El-Aziz, A., Ragy, H., Wright, D., Wong, S., Trahey, T., Stevenson, J., Spearson, S., Snell, L., Schulman, S., Sas, G., Robinson, M., Roberts, P., Raines, M., Pinter, A., Petrie, F., Pandey, M., Otis, R., Otis, J., Neas, I, Navratil, J., Moor, R., Mangat, I, Lewis, S., Lewis, C., Largy, J., Kwan, L., Kornder, J., Korley, V, Kim, R., Kelly, S., Kahlon, R., Jethoo, G., Jean, C., Jackson, A. M., Hines, K., Hines, C., Haveman, K., Gulliver, W., Grenier, M-C, Fox, B., Fournier, D., Ferleyko, L., Fearon, A., Farquhar, D., Ewert, A., Dunnigan, J., Douglass, S., Dorian, P., Djaidani, Z., Denis, I, Dehghani, P., Daheb, S., Cleveland, T., Clarke, B., Carroll, L., Burke, E., Breakwell, L., Bignell, N., Bigcanoe, J., Bergeron, C., Mooso, B., Beaudry, K., Aves, T., Aro, L., Ahmad, K., Bonet, J., Ramjattan, B., Cha, J., Lavoie, A., Parkash, R., Fikry, S., Vizel, S., MacDonald, P., Angaran, P., Coutu, B., Schweitzer, B., Hruczkowski, T., Dhillon, R., Dresser, G., Nadeau, R., Du Preez, M., Poirier, G., Heath, J., Berlingieri, J., Ayala-Paredes, F., Beaudry, P., Leader, R., Cheung, S., Pandey, A. S., Gupta, M., Luton, R., Eikelboom, J., Spyropoulos, A., Connolly, S. J., Wong, K., Wilford, E., Wallis, L., Waldman, A., Vorster, M., Tsay, I. M., Thompson, S., Tarrant, J., Swaraj, K., Sutcliffe, S., Stoyanov, N., Singleton, C., Singh, C., Shrestha, P., Shone, S., Setio, H., Seremetkoska, M., Sanders, L., Rose, J., Raynes, S., Ratcliffe, M., Rashad, H., Preston, S., Plotz, M., Paul, V, Patching, T., Patching, K., Parsons, L., Palmer, J., O'May, V, Oldfield, G., Nagalingam, V, Myers, J-D, Mussap, C., Morrison, H., McKeon, L., McIntosh, C., McCarthy, C., MacKenzie, M., Fitzpatrick, D., Fetahovic, T., Ferreira-Jardim, A., Eslick, R., Eskandari, M., Duroux, M., Dolman, M., Dixon, S., Dimitri, H., Cresp, D., Conway, B., Connelly, A., Carlton, L., Campo, M., Buckley, E., Boys, J., Bonner, M., Black, A., Beveridge, R., Batta, C., Barry, L., Aggarwala, A., Faunt, J., Carroll, P., Starmer, G., Rogers, J., Lee, A., Binnekamp, M., Jepson, N., Arstall, M., Astridge, P., Choi, A., O'Donnell, D., Crimmins, D., Blombery, P., Phan, T., Ayres, B., Zimmett, L., French, J., Eccleston, D., Kiat, H., Colquhoun, D., Catanchin, A., Coulshed, D., Kilian, J., Roberts-Thomson, P., Lehman, R., Abhayaratna, W., Van Gaal, W., Singh, B., Blenkhorn, A., Gibbs, H., Thomson, A., Thomas, N., Sword, A., Stoddart, H., Simper, H., Simmons, P., Shewring, J., Seamark, C., Saunders, P. B., Rogers, G., Rickenbach, M., Reed, R., Redpath, D., Randfield, S., Powell, K., Nadaph, M., Muvva, R., Munro, I, Lomax, L., Jeffers, L., Jacobs, P., Hay, A., Halpin, A., Goram, J., Fox, R., Flynn, A., Dooldeniya, C., Dobson, S., Cartwright, S., Bennett, J., Ayers, J., A'Court, C., Ahmad, S., Pugsley, M., Gunasegaram, J., Wong, M., Cooke, P., Beattie, A., McEleny, P., Wastling, R., McGinty, P., Bandrapalli, M., Liley, C., Vinson, P., Zaman, K., Davies, T., Forshaw, K., Veale, R., Wilkinson, J., Geatch, D., Estifano, S., Myhill, T., Lucraft, L., Batson, R., Choi, H., Stephenson, T., Hargreaves, N., Schatzberger, T., Davies, S., Baron, R. T., Haria-Shah, R., Bunney, R., Boon, M., Wong, T., Sterry, M., Shepherd, D., Walton, S., Jackson, D., Ward, B., Coates, S., Heer, A., Roberts, N., Coulson, W., Peters, S., Wilson, A., Khalaque, S., Choudhary, F., Sabir, A., Rothwell, A. C., Edwards, D., Braddick, M., Mannion, S., Aylward, M., Oliver, R., Hawkins, C., Galloway, S., Sharma, P., Heath, R., Danielsen, M., Neden, C. A., Stuart, E., Davies, R., Hart, N., Ali, A., Patel, J. R. A., Pinnock, H., Roome, P. C., Vercoe, S., Hodgins, I, Webster, J., Dau, H. S., Kamath, R., McLeod, A. J., Glencross, S., Gibbons, L., Haq, I. U., Little, H., Barrow, S., Butter, K. C., Howard, M., Zaidi, S. M. A., Chigbo, C., Thompson, R., Walls, N., Hutton, C., Jacobs, M., Abushal, S., Davies, E., Oliver, J. L., Priyadharshan, R., Rogers, S., Milne, K., Parfitt, M., Wakeling, J., Alborough, E., Kelsall, A. R., Fooks, T., Fisher, E., Litchfield, J., Bisatt, J., Clark, M., Gray, D., Bird, N., Vishwanathan, B., Howitt, A., Strieder, E., Gilliland, A., de Kare-Silver, N., Sathananthan, S., Cairns, J., Willcock, W., Ahmad, N., Sarai, B., Watson, E., Thomas, M. J., Jones, K. P., Van Zon, G., Bradshaw, C., Cumberlidge, D. F., Douglas, K., Ladha, K., Saigol, M., Wong, S. W., Patel, R. P., Lumley, L., Murdoch, W., Kernick, D., Eden, J., Weeks, P., Jones, C. P., Ainsworth, P., Davies, J. A., Russell, D., Sinha, B., Railton, T., Gallagher, A., Pandya, P., Matthews, J., Wadeson, P., Thurston, S., West, R., Stipp, Y., Macey, N., Scouller, F., Evans, P., Lumb, W., Wetherwell, S., Aldegather, J., Oginni, O., Page, M., Giles, C., Jones, H., Sharp, H., Jefferies, A., Mackay, S., Leung, D., Lehman, S., Lehman, M., Lawlor, V, Kassam, I, Juergens, C., Johnson, K., Jacobson, B., Hoffmann, B., Hesketh, L., Hegde, M. P., Hayes, K., Modi, M. H., Grabek, T., Gibbs, J., Geraghty, R., Richardson, M., Paul, C., Seamark, D., Tragen, D., Taylor, G., St Joseph, V, Thompson, J., Fairhead, S., Franklin, S., Wilson, P., Ramesh, C., Aziz, M., Paul, N., Stokes, M., Wakeman, A., Hutchinson, P., Bilas, R., Sircar, S., Singal, A., Suryani, S., Wagner, H., Gooding, T., Williams, A., McDonnell, J., Pickavance, G., Kainth, M. S., Ross, A., Jhittay, P. S., Leese, J., Evans, R., Saunders, P., Goodwin, D., Chauhan, N., Fitzmaurice, D., Varenov, V., Todoriuk, L., Stets, R., Shumakov, O., Sapatyi, A., Romanova, O., Romanenko, O., Rasputina, L., Pyvovar, S., Proshak, O., Plevak, D., Petrovskyy, R., Pavelko, M., Palamarchuk, O., Ovdiienko, T., Nemtsova, V, Mospan, M., Mochonyi, V, Medentseva, O., Matova, O., Kizim, S., Khyzhnyak, O., Kaplan, P., Kamenska, E., Ivanov, A., Daniuk, I, Chabanna, O., Burdeuna, L., Berko, G., Belegai, R., Fushtey, I, Tykhonova, S., Yagensky, A., Kraydashenko, O., Stanislavchuk, M., Sychov, O., Svyshchenko, Y., Kovalskyi, I, Andere, N., Amaro, M., Alvarez, M., Alvarez, D., Alonso, C. (Concepcion), Alonso, C. (Carmela), Prieto Diaz, M. A., Iniguez Romo, A., Marcos Gomez, G., Arcocha Torres, M. F., Vazquez Caamano, M., Vaquer Perez, J. V., Cosin Sales, J., Jimenez Navarro, M., Quiles Granado, J., Marco Macian, M. D., Garcia Riesco, L., Ridocci Soriano, F., Ripoll Vera, T., Herreros Melenchon, J., Rodriguez Alvarez, M., Jimenez Gonzalez, M., Iglesias Sanmartin, J., Moleiro Oliva, M. A., Barreda Gonzalez, M., Montero Alia, J. J., Escriva Montserrat, E., Del Val Plana, N., Almeida Fernandez, C. A., Epelde Gonzalo, F., Vida Gutierrez, M., Corros Vicente, C., Llibre, J. Bayo, Rodriguez Morato, M., Brotons Cuixart, C., Palacin Piquero, H., Monte Collado, I, Baron Esquivias, G., Gonzalez Juanatey, J. R., Merce Klein, J., Grande Ruiz, A., Iglesias Alonso, L. F., Moro Serrano, C., Gomez Pajuelo, C., Garcia Pavia, P., Motero Carrasco, J., Isart Rafecas, J., Marquez Contreras, E., Toran Monserrat, P., Tranche Iparraguirre, S., Tercedor, L., Lopez Fernandez, M. F., Alvarez Garcia, P., Vinolas, X., Zotova, I, Zhuravleva, E., Zhirov, I, Zemlianskaia, O., Volodicheva, O., Ushakov, A., Suslova, O., Speshilova, S., Sinitsina, O., Rachkova, S., Platonov, D., Ovsannikova, A., Osmolovskaya, Y., Orlov, Y., Novikova, E., Nagibovich, G., Motylev, I, Monako, G., Medvedeva, T., Machilskaya, O., Lileeva, E., Lebedeva, O., Kuvanova, M., Kurylo, B., Kupriyanova, T., Kungurtseva, O., Kuchuk, P., Kropova, O., Lowe, S., Smith, R. N., Burns, G., Conn, P., Warke, A., Mulholland, C., Poland, K., Korneeva, O., Konyushenko, D., Kolesova, T., Ivanova, Y., Gurmach, M., Gubanov, A., Gorshkova, T., Gorbunova, E., Erofeeva, S., Dumikyan, A., Chugunnaya, S., Bitakova, F., Belenkova, Y., Batalov, R., Agakhanyan, A., Edin, A., Nagibovich, O., Shapovalova, Y., Zubeeva, G., Rossovskaya, M., Sobolev, K., Polkanova, E., Moiseeva, Y., Kostenko, V, Novikova, T., Zrazhevskiy, K., Mazur, E., Shutemova, E., Sergeev, M., Chizhov, P., Aleksandrova, E., Miller, O., Barbarash, O., Vishnevsky, A., Drapkina, O., Zateyshchikov, D., Poltavskaya, M., Yakupov, E., Khokhlov, A., Egorova, L., Nikolaev, K., Kolesnikova, A., Kropacheva, E., Zateyshchikova, A., Belenky, D., Kamalov, G., Popov, S., Tereshchenko, S., Libis, R., Eltishcheva, V, Panchenko, E., Zyczynska-Szmon, M., Zakutynska-Kowalczyk, K., Wrobel, M., Wojnowski, L., Wojewoda, P., Wilgat-Szecowka, M., Wilczewski, P., Wierzbicka, A., Wieczorek, W., Wesolowska, K., Wegrzynowska, M., Walasik, P., Tybura, S., Trzcinski, G., Troszczynska, M., Traczyk, T., Szwoch, M., Szumczyk-Muszytowska, G., Szulowska, A., Szuchnik, E., Szkrobka, W., Cieszynska, A., Cieslak, K., Cichomski, R., Chojnowski, P., Chmielowski, A., Bzymek, R., Brzustowska, M., Brzozowski, W., Broton, E., Blaszczyk, D., Biernacka, A., Biedrzycki, L., Bernat, L., Bekieszczuk, E., Basiak, M., Bartnik, J., Bartkowiak, R., Barszcz, A., Araminowicz, J., Andrzejewski, D., Ambicka, M., Lesnik, J., Nessler, J., Domanska, E., Raczak, G., Rusicka-Piekarz, T., Baszak, J., Lysek, R., Mazur, S., Myszka, W., Miekus, P., Jurowiecki, J., Cymerman, K., Galbas, K., Wozniak-Skowerska, I, Kukla, P., Okopien, B., Sciborski, R., Jaworska, K., Ruszkowski, P., Glanowska, G., Ogorek, M. (Michal), Bronisz, M., Opolski, G., Trusz-Gluza, M., Chmielnicka-Pruszczynska, M., Karczmarczyk, A., Zinka, E., Lewczuk, J., Ostrowska-Pomian, B., Lajkowski, Z., Krzciuk, M., Kania, G., Olszewski, M., Minc, P., Gruchala, M., Kucharski, L., Swiatkowska-Byczynska, L., Hiczkiewicz, J., Zaluska, R., Kuzniar, J., Supinski, W., Kosior, J., Loboz-Grudzien, K., Wozakowska-Kaplon, B., Ogorek, M. (Marcin), Biedrzycka, M., Gieroba, A., Korzeniak, R., Stepinska, J., Strand, S., Ringdalen, K., O'Donovan, M., Nilsen, V, Lensebraaten, A. B., Jekthammer, A., Dominguez, I, Claussen, H., Ausen, K., Antonsen, H., Otterstad, J. E., Berg-Johansen, J., Koval, O., Ushakov, O., Mostovoy, Y., Serediuk, N., Kupnovytska, I, Kraiz, I, Zhurba, S., Karpenko, O., Tseluyko, V, Rudyk, I, Parkhomenko, A., Winnik, S., Saga, E., Henriette, I, Guinand, A., Grau, A., Elise, G., Bruegger, J., Amstutz, D., Debrunner, J., Beer, J. 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(Lars), Gustavsson, M., Olsson, L-B, Lindh, A., Liu, B., Svard, G., Borjesson, U., Egilsson, A., Elmersson, M., Henriksson, K., Linden, J., Wirdby, A., Rosenqvist, M., Ubeda Pastor, M., Torres Marques, J., Torres, C., Tobajas, G., Terns Riera, M., Teixido Fontanillas, M., Sorribes Lopez, J., Simon Valero, C., Sierra, N., Serralvo, E., Seoane Blanco, A., Senan Sanz, M. R., Santolaya, C., Sanchez Parra, S., Sanchez Mendez, L., Sanchez Calderon, P., Saez Jimenez, S., Rodriguez Garcia, M., Rodriguez, E., Rodrigo, C., Roca Saumell, C., Roca, M., Robiro Robiro, X., Rivera, R., Riquelme Sola, L., Rios, V, Rincon Diaz, L. M., Renom, R., Quintern, V, Prieto, I, Perez Carasa, M., Pereda Armayor, M., Pena Garcia, E., Pareja Ibar, I., Palomo Merchan, N., Otero Tomera, D., Ortiz Cortes, C., Ortega, V. M., Orellana Figueroa, H. N., Negrete Palma, A., Munoz Munoz, R. B., Moure Gonzalez, M., Montes, D., Montero Alia, P., Molina, M., Millan, G., Mendez Zurita, F., Mazon, P., Martinez Mena, M., Martin Vila, A., Marcus, S., Mara Guerra, J., Manzanal Rey, A., Lopez, M., Llobet Molina, M., Lezcano Gort, L. E., Lasuncion, I, Lage Bouzamayor, M. B., Juan Salvadores, P., Jimeno Besa, B., Jimenez Fernandez, M. J., Iglesias Garcia, A., Hevia Rodriguez, E., Herrero Maeso, B., Gutierrez del Val, M. del C., Guerrero Molina, A., Grigorian, L., Gonzalez, P., Gonzales Segovia, A., Gomez Perez, Y., Gomez, C., Gines Garcia, C., Gavira Saenz, M., Garcia Millan, V, Garcia Bermudez, M., Fosch, J., Ferrer, A., Fernandez Mas, E., Fernandez Escobar, E., Fernandez, M., Espallargas, A., Elorriaga Madariaga, A., Domenech Borras, A., Diaz Lopez, C. M., Dachs, M., Cotilla Marco, M., Costas, S., Prego de Faria, J. 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(Tsugihiro), Nandate, H., Zaitsu, R., Fujiura, Y. (Yoshihisa), Yoshimura, A., Numata, H., Ogawa, J., Tatematsu, H., Kamogawa, Y., Murakami, K., Wakasa, Y., Yamasawa, M., Maekawa, H., Abe, S., Kihara, H., Tsunoda, S., Saito, K. (Katsumi), Saito, K. (Kazuyuki), Fudo, T., Obunai, K., Tachibana, H., Oba, I, Kuwahata, T., Higa, S., Gushiken, M., Eto, T., Yoshida, H., Ikeda, D., Fujiura, Y. (Yoshitake), Ishizawa, M., Headlee, M., Henson, L., Herrick, C., Haas, Sylvia, ten Cate, Hugo, Accetta, Gabriele, Angchaisuksiri, Pantep, Bassand, Jean-Pierre, Camm, A. John, Corbalan, Ramon, Darius, Harald, Fitzmaurice, David A., Goldhaber, Samuel Z., Yilmaz, MEHMET BİRHAN, Goto, Shinya, Jacobson, Barry, Kayani, Gloria, Mantovani, Lorenzo G., Misselwitz, Frank, Pieper, Karen, Schellong, Sebastian M., Stepinska, Janina, Turpie, Alexander G. 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(Yuhei), Sumi, H., Nagatomo, T., Sanno, K., Fujisawa, K., Atsuchi, Y., Nagoshi, T., Seto, T., Tabuchi, T., Kameko, M., Nii, K., Oshiro, K., Takezawa, H., Nagano, S., Miyamoto, N., Iwaki, M., Nakamura, Y. (Yuichiro), Fujii, M., Okawa, M., Abe, M. (Masahiko), Abe, M. (Masatake), Abe, M. (Mitsunori), Saito, T., Mito, T., Nagao, K., Minami, J., Mita, T., Sakuma, I, Taguchi, T., Marusaki, S., Doi, H., Tanaka, M., Fujito, T., Matsuta, M., Kusumoto, T., Kakinoki, S., Ashida, K., Yoshizawa, N., Agata, J., Arasaki, O., Manita, M., Ikemura, M., Fukuoka, S., Murakami, H., Matsukawa, S., Hata, Y., Taniguchi, T., Ko, T., Kubo, H., Imamaki, M., Akiyama, M., Inagaki, M., Odakura, H., Ueda, T., Katsube, Y., Foo, C. G., Chow, J. H., Chen, D. D., Jaufeerally, F. R., Lee, Y. M., Lim, G., Nakata, A., Watanabe, H., Techigawara, M., Igarashi, M., Taga, K., Kimura, T., Tomimoto, S., Shibuya, M., Nakano, M., Ito, K., Seo, T., Hiramitsu, S., Hosokawa, H., Hoshiai, M., Hibino, M., Miyagawa, K., Horie, H. 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(Hideki), Ido, T., Iiji, O., Ikeda, H., Ikeda, K., Ikeoka, K., Imaizumi, M., Inaba, H., Inoue, T., Iseki, F., Kawada, Y., Kawai, K., Kawakami, K., Kawakami, S., Kawamoto, T., Kawano, S., Kim, J., Kira, T., Kitazawa, H., Kitazumi, H., Kito, T., Kobayashi, T., Koeda, T., Kojima, J., Komatsu, H., Komatsu, I, Koshibu, Y., Kotani, T., Kozuka, T., Kumai, Y., Kumazaki, T., Maeda, I, Maeda, K., Maruyama, Y., Matsui, S., Matsushita, K., Matsuura, Y., Mineoi, K., Mitsuhashi, H., Miura, N., Miyaguchi, S., Miyajima, S., Miyamoto, H., Miyashita, A., Miyata, S., Mizuguchi, I, Mizuno, A., Mori, T., Moriai, O., Morishita, K., Murai, O., Nagai, S. (Sho), Nagai, S. 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S., Pickavance, G., Mcdonnell, J., Williams, A., Gooding, T., Wagner, H., Suryani, S., Singal, A., Sircar, S., Bilas, R., Hutchinson, P., Wakeman, A., Stokes, M., Paul, N., Aziz, M., Ramesh, C., Wilson, P., Franklin, S., Fairhead, S., Thompson, J., St Joseph, V., Taylor, G., Tragen, D., Seamark, D., Paul, C., Richardson, M., Jefferies, A., Sharp, H., Jones, H., Giles, C., Page, M., Oginni, O., Aldegather, J., Wetherwell, S., Lumb, W., Evans, P., Scouller, F., Macey, N., Stipp, Y., West, R., Thurston, S., Wadeson, P., Matthews, J., Pandya, P., Gallagher, A., Railton, T., Sinha, B., Russell, D., Davies, J. A., Ainsworth, P., Jones, C. P., Weeks, P., Eden, J., Kernick, D., Murdoch, W., Lumley, L., Patel, R. P., Wong, S. W., Saigol, M., Ladha, K., Douglas, K., Cumberlidge, D. F., Bradshaw, C., Van Zon, G., Jones, K. P., Thomas, M. J., Watson, E., Sarai, B., Ahmad, N., Willcock, W., Cairns, J., Sathananthan, S., de Kare-Silver, N., Gilliland, A., Strieder, E., Howitt, A., Vishwanathan, B., Bird, N., Gray, D., Clark, M., Bisatt, J., Litchfield, J., Fisher, E., Fooks, T., Kelsall, A. R., Alborough, E., Wakeling, J., Parfitt, M., Milne, K., Rogers, S., Priyadharshan, R., Oliver, J. L., Davies, E., Abushal, S., Jacobs, M., Hutton, C., Walls, N. I., Thompson, R., Chigbo, C., Zaidi, S. M. A., Howard, M., Butter, K. C., Barrow, S., Little, H., Haq, I. U., Gibbons, L., Glencross, S., Mcleod, A. J., Poland, K., Mulholland, C., Warke, A., Conn, P., Burns, G., Smith, R. N., Lowe, S., Kamath, R., Dau, H. S., Webster, J., Hodgins, I., Vercoe, S., Roome, P. C., Pinnock, H., Patel, J. R. A., Ali, A., Hart, N., Davies, R., Stuart, E., Neden, C. A., Danielsen, M., Heath, R., Sharma, P., Galloway, S., Hawkins, C., Oliver, R., Aylward, M., Mannion, S., Braddick, M., Edwards, D., Rothwell, A. C., Sabir, A., Choudhary, F., Khalaque, S., Wilson, A., Peters, S., Coulson, W., Roberts, N., Heer, A., Coates, S., Ward, B., Jackson, D., Walton, S., Shepherd, D., Sterry, M., Wong, T., Boon, M., Bunney, R., Haria-Shah, R., Baron, R. T., Davies, S., Schatzberger, T., Hargreaves, N., Stephenson, T., Choi, H., Batson, R., Lucraft, L., Myhill, T., Estifano, S., Geatch, D., Wilkinson, J., Veale, R., Forshaw, K., Davies, T., Zaman, K., Vinson, P., Liley, C., Bandrapalli, M., Mcginty, P., Wastling, R., Mceleny, P., Beattie, A., Cooke, P., Wong, M., Gunasegaram, J., Pugsley, M., Ahmad, S., A'Court, C., Ayers, J., Bennett, J., Cartwright, S., Dobson, S., Dooldeniya, C., Flynn, A., Fox, R., Goram, J., Halpin, A., Hay, A., Jacobs, P., Jeffers, L., Lomax, L., Munro, I., Muvva, R., Nadaph, M., Powell, K., Randfield, S., Redpath, D., Reed, R., Rickenbach, M., Rogers, G., Saunders, P. B., Seamark, C., Shewring, J., Simmons, P., Simper, H., Stoddart, H., Sword, A., Thomas, N., Thomson, A., Blenkhorn, A., Singh, B., Van Gaal, W., Abhayaratna, W., Lehman, R., Roberts-Thomson, P., Kilian, J., Coulshed, D., Catanchin, A., Colquhoun, D., Kiat, H., Eccleston, D., French, J., Zimmett, L., Ayres, B., Phan, T., Blombery, P., Crimmins, D., O'Donnell, D., Choi, A., Astridge, P., Arstall, M., Jepson, N., Binnekamp, M., Lee, A., Rogers, J., Starmer, G., Carroll, P., Faunt, J., Aggarwala, A., Barry, L., Batta, C., Beveridge, R., Black, A., Bonner, M., Boys, J., Buckley, E., Campo, M., Carlton, L., Connelly, A., Conway, B., Cresp, D., Dimitri, H., Dixon, S., Dolman, M., Duroux, M., Eskandari, M., Eslick, R., Ferreira-Jardim, A., Fetahovic, T., Fitzpatrick, D., Geraghty, R., Gibbs, J., Grabek, T., Modi, M. H., Hayes, K., Hegde, M. P., Hesketh, L., Hoffmann, B., Johnson, K., Juergens, C., Kassam, I., Lawlor, V., Lehman, M., Lehman, S., Leung, D., Mackay, S., Mackenzie, M., Mccarthy, C., Mcintosh, C., Mckeon, L., Morrison, H., Mussap, C., Myers, J. -D., Nagalingam, V., Oldfield, G., O'May, V., Palmer, J., Parsons, L., Patching, K., Patching, T., Paul, V., Plotz, M., Preston, S., Rashad, H., Ratcliffe, M., Raynes, S., Rose, J., Sanders, L., Seremetkoska, M., Setio, H., Shone, S., Shrestha, P., Singh, C., Singleton, C., Stoyanov, N., Sutcliffe, S., Swaraj, K., Tarrant, J., Thompson, S., Tsay, I. M., Vorster, M., Waldman, A., Wallis, L., Wilford, E., Wong, K., Luton, R., Gupta, M., Pandey, A. S., Cheung, S., Leader, R., Beaudry, P., Ayala-Paredes, F., Berlingieri, J., Heath, J., Poirier, G., Du Preez, M., Nadeau, R., Dresser, G., Dhillon, R., Hruczkowski, T., Schweitzer, B., Coutu, B., Angaran, P., Macdonald, P., Vizel, S., Fikry, S., Parkash, R., Lavoie, A., Cha, J., Ramjattan, B., Bonet, J., Ahmad, K., Aro, L., Aves, T., Beaudry, K., Bergeron, C., Bigcanoe, J., Bignell, N., Breakwell, L., Burke, E., Carroll, L., Clarke, B., Cleveland, T., Daheb, S., Dehghani, P., Denis, I., Djaidani, Z., Dorian, P., Douglass, S., Dunnigan, J., Ewert, A., Farquhar, D., Fearon, A., Ferleyko, L., Fournier, D., Fox, B., Grenier, M. -C., Gulliver, W., Haveman, K., Hines, C., Hines, K., Jackson, A. M., Jean, C., Jethoo, G., Kahlon, R., Kelly, S., Kim, R., Korley, V., Kornder, J., Kwan, L., Largy, J., Lewis, C., Lewis, S., Mangat, I., Moor, R., Navratil, J., Neas, I., Otis, J., Otis, R., Pandey, M., Petrie, F., Pinter, A., Raines, M., Roberts, P., Robinson, M., Sas, G., Schulman, S., Snell, L., Spearson, S., Stevenson, J., Trahey, T., Wong, S., Wright, D., El-Aziz, A. A., Seif, S. K. A., El Din, M. G., El Etriby, S., Elbahry, A., El-Etreby, A., Elkhadem, M., Katta, A., Khairy, T., Mowafy, A., Nawar, M., Ohanissian, A., Reda, A., Reda, M., Salem, H., Sami, N., Samir, S., Setiha, M., Sobhy, M., Soliman, A., Taha, N., Tawfik, M., Zaatout, E., Kettles, D., Bayat, J., Siebert, H., Horak, A., Kelfkens, Y., Garda, R., Pillay, T., Guerra, M., van Zyl, L., Theron, H., Murray, A., Louw, R., Greyling, D., Mntla, P., Ueckermann, V., Loghdey, R., Ismail, S., Ahmed, F., Engelbrecht, J., Ramdass, A., Maharajh, S., Oosthuysen, W., Angel, G., Bester, C., Booysen, M., Boshoff, C., Cannon, C., Cassimjee, S., Chami, C., Conway, G., Davids, A., de Meyer, L., Du Plessis, G., Ellis, T., Henley, L., Karsten, M., Loyd, E., Marks, J., Mavhusa, L., Mostert, M., Page, A., Rikhotso, L., Salie, M., Sasto, J., Shaik, F., Skein, A., Smith, L., Tarr, G., Tau, T., van Zyl, F., Yousef, G., Agrawal, A., Nathani, M., Ibrahim, M., Esheiba, E. M., Singh, R., Naguib, A., Abu-Mahfouz, M., Al Omairi, M., Al Naeemi, A., Maruthanayagam, R., Bazargani, N., Wassef, A., Gupta, R., Khan, M., Subbaraman, B., Abdul, A., Al Mulla, A., El Bardisy, S., Haridas, P., Jadhav, S., Magdaluyo, K., Makdad, M., Maqsood, I., Mohamed, R., Sharma, N., Sharma, R., Thanzeel, M., Canosa, R., Rama, P., Blumberg, E., Garcia, J., Mullen, P., Wilson, V., Quick, A., Ferrick, K., Kutayli, W. M., Cox, M., Franco, M., Falkowski, S., Mendelson, R., Williams, M., Miller, S., Beach, S., Alfieri, A., Gutowski, T., Haque, I., Reddy, R., Ahmed, W., Delafontaine, P., Diercks, D., Theodoro, D., Remmel, K., Alberts, M., Ison, R., Noveck, H., Duffy, P., Pitta, S., Nishijima, D., Treasure, C., Asafu-Adjaye, N., Ball, K., Bartlett, M., Bentley, M., Bowers, S., Brown, A., Browne, A., Cameron-Watts, J., Canova, M., Cassidy, D., Cervellione, K., Congal, S., Depauw, J., Dickerson, A., Eley, M., Evans, L., Felpel, S., Ferdinand, K., Fielder, D., Gentry, P., Haideri, A., Hakimi, F., Harbour, T., Hartranft, E., Hawkins, B., Headlee, M., Henson, L., Herrick, C., Hicks, T., Jasinski, S., Jones, A., Jones, L., Jones, P., Karl, S., Keeling, M., Kerr, J., Knowles, P., Langdon, J., Lay, M., Lee, J. A., Lincoln, T., Malone, E., Merliss, A., Merritt, D., Minardo, J., Mooso, B., Orosco, C., Palumbo, V., Parker, M., Parrott, T., Paserchia, S., Pearl, G., Peterson, J., Pickelsimer, N., Purcell, T., Raynor, J., Raziano, S., Richard, C., Richardson, T., Robertson, C., Sage, A., Sanghera, T., Shaw, P., Shoemaker, J., Smith, K., Stephanie, B., Thatcher, A., Theobald, H., Thompson, N., Treasure, L., Tripti, T., Verdi, C., Worthy, V., RS: CARIM - R1.04 - Clinical thrombosis and haemostasis, MUMC+: MA Alg Interne Geneeskunde (9), Interne Geneeskunde, Biochemie, Haas, S, Cate, H, Accetta, G, Angchaisuksiri, P, Bassand, J, John Camm, A, Corbalan, R, Darius, H, Fitzmaurice, D, Goldhaber, S, Goto, S, Jacobson, B, Kayani, G, Mantovani, L, Misselwitz, F, Pieper, K, Schellong, S, Stepinska, J, Turpie, A, Eickels, M, Kakkar, A, Ten Cate, Hugo [0000-0001-7796-4463], Accetta, Gabriele [0000-0002-3794-6620], and Apollo - University of Cambridge Repository
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Male ,Registrie ,Vitamin K ,Organic chemistry ,lcsh:Medicine ,030204 cardiovascular system & hematology ,Pathology and Laboratory Medicine ,Antiplatelet Therapy ,Vascular Medicine ,Geographical Locations ,0302 clinical medicine ,Risk Factors ,Atrial Fibrillation ,Medicine and Health Sciences ,030212 general & internal medicine ,Prospective Studies ,Registries ,lcsh:Science ,Prospective cohort study ,Stroke ,education.field_of_study ,Multidisciplinary ,Pharmaceutics ,Mortality rate ,Atrial fibrillation ,Vitamins ,Vitamin K antagonist ,Middle Aged ,ddc ,Physical sciences ,Hemorrhagic Stroke ,Chemistry ,Treatment Outcome ,Neurology ,Female ,Arrhythmia ,Research Article ,Human ,medicine.medical_specialty ,endocrine system ,Asia ,Death Rates ,medicine.drug_class ,Cerebrovascular Diseases ,B vitamins ,Population ,Cardiology ,Hemorrhage ,Chemical compounds ,03 medical and health sciences ,Antiplatyhelmintic Agents ,Signs and Symptoms ,Drug Therapy ,Population Metrics ,Diagnostic Medicine ,Internal medicine ,Organic compounds ,medicine ,Humans ,International Normalized Ratio ,education ,Demography ,Ischemic Stroke ,Biochemistry, Genetics and Molecular Biology (all) ,Population Biology ,business.industry ,Risk Factor ,lcsh:R ,Anticoagulant ,Biology and Life Sciences ,Anticoagulants ,ta3121 ,medicine.disease ,Antiplatyhelmintic Agent ,Prospective Studie ,People and Places ,Attributable risk ,Physical therapy ,lcsh:Q ,business ,RC - Abstract
Aims Vitamin K antagonists (VKAs) need to be individually dosed. International guidelines recommend a target range of international normalised ratio (INR) of 2.0–3.0 for stroke prevention in atrial fibrillation (AF). We analysed the time in this therapeutic range (TTR) of VKA-treated patients with newly diagnosed AF in the ongoing, global, observational registry GARFIELD-AF. Taking TTR as a measure of the quality of patient management, we analysed its relationship with 1-year outcomes, including stroke/systemic embolism (SE), major bleeding, and all-cause mortality. Methods and Results TTR was calculated for 9934 patients using 136,082 INR measurements during 1-year follow-up. The mean TTR was 55.0%; values were similar for different VKAs. 5851 (58.9%) patients had TTR
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- 2016
7. Disturbance function for soil disturbed state strength based on X-ray computed tomography triaxial test
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Li, X., primary, Wang, S. J., additional, He, B. H., additional, and Chen, Y. Frank, additional
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- 2019
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8. Genome-wide association meta-analysis of circulating odd-numbered chain saturated fatty acids: Results from the CHARGE Consortium
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de Oliveira Otto, Marcia C., primary, Lemaitre, Rozenn N., additional, Sun, Qi, additional, King, Irena B., additional, Wu, Jason H. Y., additional, Manichaikul, Ani, additional, Rich, Stephen S., additional, Tsai, Michael Y., additional, Chen, Y. D., additional, Fornage, Myriam, additional, Weihua, Guan, additional, Aslibekyan, Stella, additional, Irvin, Marguerite R., additional, Kabagambe, Edmond K., additional, Arnett, Donna K., additional, Jensen, Majken K., additional, McKnight, Barbara, additional, Psaty, Bruce M., additional, Steffen, Lyn M., additional, Smith, Caren E., additional, Risérus, Ulf, additional, Lind, Lars, additional, Hu, Frank B., additional, Rimm, Eric B., additional, Siscovick, David S., additional, and Mozaffarian, Dariush, additional
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- 2018
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9. Myeloperoxidase mediated HDL oxidation and HDL proteome changes do not contribute to dysfunctional HDL in Chinese subjects with coronary artery disease
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Wang, Guisong, primary, Mathew, Anna Vachaparampil, additional, Yu, Haiyi, additional, Li, Lei, additional, He, Liyun, additional, Gao, Wei, additional, Liu, Xiaodan, additional, Guo, Yanhong, additional, Byun, Jaeman, additional, Zhang, Jifeng, additional, Chen, Y. Eugene, additional, and Pennathur, Subramaniam, additional
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- 2018
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10. Research on safety supervision and management system of China railway based on association rule and DEMATEL
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Jia Liu, Yansheng Wang, Cunbao Deng, Zhixin Jin, Gaolei Wang, Chen Yang, and Xiaoyu Li
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Medicine ,Science - Published
- 2023
11. Light therapy for sleep disturbance comorbid depression in relation to neural circuits and interactive hormones-A systematic review.
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Chen Yaodong, Yingzi Zhang, Guo Feng, Yuanfang Lei, Qiuping Liu, and Yang Liu
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Medicine ,Science - Abstract
AimTo provide an overview of the evidence on the effect of light therapy on sleep disturbance and depression, identify the light-active neural and hormonal correlates of the effect of light therapy on sleep disturbance comorbid depression (SDCD), and construct the mechanism by which light therapy alleviates SDCD.MethodsArticles published between 1981 and 2021 in English were accessed using Science Direct, Elsevier, and Google Scholar following a three-step searching process via evolved keywords. The evidence level, reliability, and credibility of the literature were evaluated using the evidence pyramid method, which considers the article type, impact factor, and journal citation report (JCR) partition.ResultsA total of 372 articles were collected, of which 129 articles fit the inclusion criteria and 44% were at the top of the evidence pyramid hierarchy; 50% were in the first quarter of the JCR partitions. 114 articles provided specific neural and hormonal evidence of light therapy and were further divided into three groups: 37% were related to circadian regulation circuits, 27% were related to emotional regulation circuits, and 36% were related to hormones.ConclusionsFirst, neural and hormonal light-active pathways for alleviating sleep disturbance or depression were identified, based on which the neural correlates of SDCD were located. Second, the light responses and interactions of hormones were reviewed and summarized, which also provided a way to alleviate SDCD. Finally, the light-active LHb and SCN exert extensive regulation impacts on the circadian and emotional circuits and hormones, forming a dual-core system for alleviating SDCD.
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- 2023
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12. Implementation of postpartum navigation for low-income individuals at an urban academic medical center.
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Hannah M Green, Viridiana Carmona-Barrera, Laura Diaz, Chen Yeh, Brittney Williams, Ka'Derricka Davis, Michelle A Kominiarek, Joe Feinglass, William A Grobman, Chloe Zera, and Lynn M Yee
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Medicine ,Science - Abstract
BackgroundPatient navigation, a patient-centered intervention to promote comprehensive health care, is an emerging innovation in obstetrics to optimize postpartum care. We aimed to evaluate the implementation of a novel postpartum patient navigation program at an urban academic medical center.MethodsThis mixed-methods study analyzed the implementation of a postpartum patient navigation program within an ongoing randomized control trial. This study analyzed three navigators' logs of interactions with 50 patients, care team members, and community organizations throughout patients' first year postpartum. We categorized and quantified interactions by topic addressed, care team member interacted with, and communication mode used. We also conducted semi-structured interviews with each navigator every three months (5 interviews per navigator), emphasizing navigation experiences, relationships with patients and care teams, integration in the care team, and healthcare system gaps. Interview data were analyzed using the constant comparative method to identify themes using the constructs of the Consolidated Framework for Implementation Research (CFIR).ResultsAnalysis of navigator logs revealed a high patient need level, especially in the first 3 months postpartum. CFIR-guided analysis of intervention characteristics revealed positive perceptions of navigation's utility due to its adaptability. Navigation's complexity, however, posed an early obstacle to implementation that diminished over time. Outer setting analysis indicated navigators addressed patient needs through interactions with multiple systems. Despite clinicians' initial unfamiliarity with navigation, inner setting analysis suggested ongoing communication and electronic medical record use facilitated integration into the care team. Regarding individual and process characteristics, findings emphasized how navigator self-efficacy and confidence increased with experience (individual) and was facilitated by comprehensive training and reflection (process). Overall, barriers to implementation included unfamiliarity, varied patient engagement, and innovation complexity. Facilitators included high patient need, communication with outside organizations, medical record usage, navigator characteristics (self-efficacy, communication skills, and personal growth), a comprehensive training period, consistent reflection, high relative advantage, and high adaptability to patient need.ConclusionPatient navigation is a promising innovation to improve postpartum care coordination and support care team efforts. The successful implementation of navigation in this study indicates that, if shown to improve patient outcomes, obstetric navigation could be a component of patient-centered postpartum care.
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- 2023
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13. Occipital nerve stimulation for chronic migraine--a systematic review and meta-analysis
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Chen, Y-F., Bramley, George, Unwin, Gemma, Hanu-Cernat, Dalvina, Dretzke, Janine, Moore, David J., Bayliss, Sue, Cummins, Carole, and Lilford, Richard
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Science ,Medicine ,RC - Abstract
BackgroundChronic migraine is a debilitating headache disorder that has significant impact on quality of life. Stimulation of peripheral nerves is increasingly being used to treat chronic refractory pain including headache disorders. This systematic review examines the effectiveness and adverse effects of occipital nerve stimulation (ONS) for chronic migraine.MethodsDatabases, including the Cochrane Library, MEDLINE, EMBASE, CINAHL and clinical trial registers were searched to September 2014. Randomized controlled trials (RCTs), other controlled and uncontrolled observational studies and case series (n≥ 10) were eligible. RCTs were assessed using the Cochrane risk of bias tool. Meta-analysis was carried out using a random-effects model. Findings are presented in summary tables and forest plots.ResultsFive RCTs (total n=402) and seven case series (total n=115) met the inclusion criteria. Pooled results from three multicenter RCTs show that ONS was associated with a mean reduction of 2.59 days (95% CI 0.91 to 4.27, I2=0%) of prolonged, moderate to severe headache per month at 3 months compared with a sham control. Results for other outcomes generally favour ONS over sham controls but quantitative analysis was hampered by incomplete publication and reporting of trial data. Lead migration and infections are common and often require revision surgery. Open-label follow-up of RCTs and case series suggest long-term effectiveness can be maintained in some patients but evidence is limited.ConclusionsWhile the effectiveness of ONS compared to sham control has been shown in multiple RCTs, the average effect size is modest and may be exaggerated by bias as achieving effective blinding remains a methodological challenge. Further measures to reduce the risk of adverse events and revision surgery are needed.Systematic review registrationthis systematic review is an update and expanded work of part of a broader review registered with PROSPERO. Registration No. CRD42012002633.
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- 2015
14. A Structural Equation Modeling Approach to Examining Factors Influencing Outcomes with Cochlear Implant in Mandarin-Speaking Children
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Sokolowski, B, Chen, Y, Xi, X, Wong, LLN, and Zhu, S
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Hearing aid ,Male ,Vocabulary ,medicine.medical_specialty ,China ,Speech perception ,genetic structures ,medicine.medical_treatment ,media_common.quotation_subject ,lcsh:Medicine ,Audiology ,Mandarin Chinese ,Language Development ,Structural equation modeling ,Cochlear implant ,Perception ,medicine ,otorhinolaryngologic diseases ,Humans ,lcsh:Science ,media_common ,Multidisciplinary ,Speech Intelligibility ,lcsh:R ,Age Factors ,Infant ,Cochlear Implantation ,language.human_language ,Language development ,Cochlear Implants ,Child, Preschool ,language ,Speech Perception ,Female ,lcsh:Q ,Psychology ,Research Article - Abstract
Objective To examine the direct and indirect effects of demographical factors on speech perception and vocabulary outcomes of Mandarin-speaking children with cochlear implants (CIs). Methods 115 participants implanted before the age of 5 and who had used CI before 1 to 3 years were evaluated using a battery of speech perception and vocabulary tests. Structural equation modeling was used to test the hypotheses proposed. Results Early implantation significantly contributed to speech perception outcomes while having undergone a hearing aid trial (HAT) before implantation, maternal educational level (MEL), and having undergone universal newborn hearing screening (UNHS) before implantation had indirect effects on speech perception outcomes via their effects on age at implantation. In addition, both age at implantation and MEL had direct and indirect effects on vocabulary skills, while UNHS and HAT had indirect effects on vocabulary outcomes via their effects on age at implantation. Conclusion A number of factors had indirect and direct effects on speech perception and vocabulary outcomes in Mandarin-speaking children with CIs and these factors were not necessarily identical to those reported among their English-speaking counterparts.
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- 2015
15. Cardiomyocyte Overexpression of FABP4 Aggravates Pressure Overload-Induced Heart Hypertrophy
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Zhang, Ji, primary, Qiao, Congzhen, additional, Chang, Lin, additional, Guo, Yanhong, additional, Fan, Yanbo, additional, Villacorta, Luis, additional, Chen, Y. Eugene, additional, and Zhang, Jifeng, additional
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- 2016
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16. Clinical features of patients with dysthymia in a large cohort of Han Chinese women with recurrent major depression
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Wu, W, Wang, Z, Wei, Y, Zhang, G, Shi, S, Gao, J, Li, Y, Tao, M, Zhang, K, Wang, X, Gao, C, Yang, L, Li, K, Shi, J, Wang, G, Liu, L, Zhang, J, Du, B, Jiang, G, Shen, J, Liu, Y, Liang, W, Sun, J, Hu, J, Liu, T, Miao, G, Meng, H, Hu, C, Huang, G, Li, G, Ha, B, Deng, H, Mei, Q, Zhong, H, Gao, S, Sang, H, Zhang, Y, Fang, X, Yu, F, Yang, D, Chen, Y, Hong, X, Chen, G, Cai, M, Song, Y, Pan, J, Dong, J, Pan, R, Zhang, W, Shen, Z, Liu, Z, Gu, D, Liu, X, Zhang, Q, Kendler, KS, Flint, J, and Zhang, Z
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Adult ,China ,Clinical Research Design ,Psychological Stress ,lcsh:Medicine ,Environment ,Neuroses ,Social and Behavioral Sciences ,behavioral disciplines and activities ,Cohort Studies ,Life Change Events ,Asian People ,Risk Factors ,Surveys and Questionnaires ,mental disorders ,Odds Ratio ,Humans ,Psychology ,lcsh:Science ,Psychiatry ,Depressive Disorder, Major ,Behavior ,Mood Disorders ,lcsh:R ,Middle Aged ,Anxiety Disorders ,Mental Health ,Medicine ,Female ,lcsh:Q ,Disease Susceptibility ,Dysthymic Disorder ,Research Article - Abstract
BACKGROUND: Dysthymia is a form of chronic mild depression that has a complex relationship with major depressive disorder (MDD). Here we investigate the role of environmental risk factors, including stressful life events and parenting style, in patients with both MDD and dysthymia. We ask whether these risk factors act in the same way in MDD with and without dysthymia. RESULTS: We examined the clinical features in 5,950 Han Chinese women with MDD between 30-60 years of age across China. We confirmed earlier results by replicating prior analyses in 3,950 new MDD cases. There were no significant differences between the two data sets. We identified sixteen stressful life events that significantly increase the risk of dysthymia, given the presence of MDD. Low parental warmth, from either mother or father, increases the risk of dysthymia. Highly threatening but short-lived threats (such as rape) are more specific for MDD than dysthymia. While for MDD more severe life events show the largest odds ratio versus controls, this was not seen for cases of MDD with or without dysthymia. CONCLUSIONS: There are increased rates of stressful life events in MDD with dysthymia, but the impact of life events on susceptibility to dysthymia with MDD differs from that seen for MDD alone. The pattern does not fit a simple dose-response relationship, suggesting that there are moderating factors involved in the relationship between environmental precipitants and the onset of dysthymia. It is possible that severe life events in childhood events index a general susceptibility to chronic depression, rather than acting specifically as risk factors for dysthymia.
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- 2013
17. Functional KV10.1 Channels Localize to the Inner Nuclear Membrane
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Chen, Y., Sánchez, A., Rubio, M., Kohl, T., Pardo, L., and Stühmer, W.
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Anatomy and Physiology ,Patch-Clamp Techniques ,Nuclear Envelope ,Golgi Apparatus ,CHO Cells ,Biochemistry ,Signaling Pathways ,Ion Channels ,Mice ,Cricetulus ,Cricetinae ,Molecular Cell Biology ,Signaling in Cellular Processes ,Animals ,Humans ,Biology ,Cell Proliferation ,Cell Nucleus ,Cell Membrane ,Membrane Proteins ,Cellular Structures ,Ether-A-Go-Go Potassium Channels ,Electrophysiology ,Cellular Neuroscience ,Cytochemistry ,NIH 3T3 Cells ,Molecular Neuroscience ,Transmembrane Signaling ,Research Article ,Signal Transduction ,Neuroscience - Abstract
Ectopically expressed human K(V)10.1 channels are relevant players in tumor biology. However, their function as ion channels at the plasma membrane does not totally explain their crucial role in tumors. Both in native and heterologous systems, it has been observed that a majority of K(V)10.1 channels remain at intracellular locations. In this study we investigated the localization and possible roles of perinuclear K(V)10.1. We show that K(V)10.1 is expressed at the inner nuclear membrane in both human and rat models; it co-purifies with established inner nuclear membrane markers, shows resistance to detergent extraction and restricted mobility, all of them typical features of proteins at the inner nuclear membrane. K(V)10.1 channels at the inner nuclear membrane are not all transported directly from the ER but rather have been exposed to the extracellular milieu. Patch clamp experiments on nuclei devoid of external nuclear membrane reveal the existence of channel activity compatible with K(V)10.1. We hypothesize that K(V)10.1 channels at the nuclear envelope might participate in the homeostasis of nuclear K(+), or indirectly interact with heterochromatin, both factors known to affect gene expression.
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- 2011
18. A Genome-Wide Investigation of MicroRNA Expression Identifies Biologically-Meaningful MicroRNAs That Distinguish between High-Risk and Low-Risk Intraductal Papillary Mucinous Neoplasms of the Pancreas
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Permuth-Wey, Jennifer, primary, Chen, Y. Ann, additional, Fisher, Kate, additional, McCarthy, Susan, additional, Qu, Xiaotao, additional, Lloyd, Mark C., additional, Kasprzak, Agnieszka, additional, Fournier, Michelle, additional, Williams, Vonetta L., additional, Ghia, Kavita M., additional, Yoder, Sean J., additional, Hall, Laura, additional, Georgeades, Christina, additional, Olaoye, Funmilayo, additional, Husain, Kazim, additional, Springett, Gregory M., additional, Chen, Dung-Tsa, additional, Yeatman, Timothy, additional, Centeno, Barbara Ann, additional, Klapman, Jason, additional, Coppola, Domenico, additional, and Malafa, Mokenge, additional
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- 2015
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19. Bentonite clay with different nitrogen sources can effectively reduce nitrate leaching from sandy soil.
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Zahid Hussain, Tang Cheng, Muhammad Irshad, Riaz Ahmed Khattak, Chen Yao, Di Song, and Muhammad Mohiuddin
- Subjects
Medicine ,Science - Abstract
Nitrate (NO3-1) leaching from soils results in the lower soil fertility, reduced crop productivity and increased water pollution. The effects of bentonite clay mixed with various nitrogen (N) fertilizers on NO3-1 leaching from sandy soils haven't been extensively studied. Therefore, the present lysimetric study determined NO3-1 leaching from bentonite [0, 2 and 4% (m/m)] treated sandy soil under three N sources (calcium nitrate [Ca(NO3)2], ammonium chloride [NH4Cl], and urea [CO(NH2)2] at the rate of 300 kg N ha-1). Results showed that bentonite markedly reduced NO3-1 release in the leachate, while 4% bentonite retained higher NO3 in the soil. The NO3-1 leaching from sandy soil varied with N sources as Ca(NO3)2 > NH4Cl > (CO(NH2)2. At early stages of leaching, higher concentrations of NO3-1 were detected in leachate with both NH4Cl and Ca(NO3)2, but leaching of NO3-1 increased with urea at later leaching stages. The amount of total NO3-1 retained in soil was conversely related to the amount of NO3-1 in the leachate. This study indicated that soil amendment with bentonite could efficiently mitigate NO3-1 leaching from sandy soil and hence prevent N fertilizer losses and groundwater pollution.
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- 2022
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20. Estimating the effect of cesarean delivery on long-term childhood health across two countries
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Ayya Keshet, Hagai Rossman, Smadar Shilo, Shiri Barbash-Hazan, Guy Amit, Maytal Bivas-Benita, Chen Yanover, Irena Girshovitz, Pinchas Akiva, Avi Ben-Haroush, Eran Hadar, Arnon Wiznitzer, and Eran Segal
- Subjects
Medicine ,Science - Abstract
Assessing the impact of cesarean delivery (CD) on long-term childhood outcomes is challenging as conducting a randomized controlled trial is rarely feasible and inferring it from observational data may be confounded. Utilizing data from electronic health records of 737,904 births, we defined and emulated a target trial to estimate the effect of CD on predefined long-term pediatric outcomes. Causal effects were estimated using pooled logistic regression and standardized survival curves, leveraging data breadth to account for potential confounders. Diverse sensitivity analyses were performed including replication of results in an external validation set from the UK including 625,044 births. Children born in CD had an increased risk to develop asthma (10-year risk differences (95% CI) 0.64% (0.31, 0.98)), an average treatment effect of 0.10 (0.07–0.12) on body mass index (BMI) z-scores at age 5 years old and 0.92 (0.68–1.14) on the number of respiratory infection events until 5 years of age. A positive 10-year risk difference was also observed for atopy (10-year risk differences (95% CI) 0.74% (-0.06, 1.52)) and allergy 0.47% (-0.32, 1.28)). Increased risk for these outcomes was also observed in the UK cohort. Our findings add to a growing body of evidence on the long-term effects of CD on pediatric morbidity, may assist in the decision to perform CD when not medically indicated and paves the way to future research on the mechanisms underlying these effects and intervention strategies targeting them.
- Published
- 2022
21. Cardiovascular disease protein biomarkers are associated with kidney function: The Framingham Heart Study
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Amena Keshawarz, Shih-Jen Hwang, Gha Young Lee, Zhi Yu, Chen Yao, Anna Köttgen, and Daniel Levy
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Medicine ,Science - Abstract
Background Biomarkers common to chronic kidney disease (CKD) and cardiovascular disease (CVD) may reflect early impairments underlying both diseases. Methods We evaluated associations of 71 CVD-related plasma proteins measured in 2,873 Framingham Heart Study (FHS) Offspring cohort participants with cross-sectional continuous eGFR and with longitudinal change in eGFR from baseline to follow-up (ΔeGFR). We also evaluated the associations of the 71 CVD proteins with the following dichotomous secondary outcomes: prevalent CKD stage ≥3 (cross-sectional), new-onset CKD stage ≥3 (longitudinal), and rapid decline in eGFR (longitudinal). Proteins significantly associated with eGFR and ΔeGFR were subsequently validated in 3,951 FHS Third Generation cohort participants and were tested using Mendelian randomization (MR) analysis to infer putatively causal relations between plasma protein biomarkers and kidney function. Results In cross-sectional analysis, 37 protein biomarkers were significantly associated with eGFR at FDRDiscussion/conclusions Eight protein biomarkers were consistently associated with eGFR in cross-sectional and longitudinal analysis in both cohorts and may capture early kidney impairment; others were implicated in association and causal inference analyses. A subset of CVD protein biomarkers may contribute causally to the pathogenesis of kidney impairment and should be studied as targets for CKD treatment and early prevention.
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- 2022
22. Association of 71 cardiovascular disease-related plasma proteins with pulmonary function in the community.
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Jenna N McNeill, Dong Heon Lee, Shih-Jen Hwang, Paul Courchesne, Chen Yao, Tianxiao Huan, Roby Joehanes, George T O'Connor, Jennifer E Ho, and Daniel Levy
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Medicine ,Science - Abstract
RationaleIt has been speculated that shared mechanisms underlie respiratory and cardiovascular diseases (CVD) including systemic inflammation or mutual risk factors. In this context, we sought to examine the associations of CVD-related plasma proteins with lung function as measured by spirometry in a large community-based cohort of adults.MethodsThe study included 5777 Framingham Heart Study participants who had spirometry and measurement of 71 CVD-related plasma proteins. The association of plasma proteins with lung function was assessed cross-sectionally and longitudinally using models accounting for familial correlations. Linear mixed models were used for the following measurements: FEV1%predicted, FVC%predicted, and FEV1/FVC ratio with secondary analyses examining obstructive and restrictive physiology at baseline and their new onset during follow up.Measurements and main resultsAmong the 71 CVD-related plasma proteins, 13 proteins were associated in cross-sectional analyses with FEV1%predicted, 17 proteins were associated with FVC%predicted, and 1 protein was associated with FEV1/FVC. The proteins with the greatest inverse relations to FEV1%predicted and FVC%predicted included leptin, adrenomedullin, and plasminogen activator inhibitor-1; in contrast there were three proteins with positive relations to FEV1%predicted and FVC%predicted including insulin growth factor binding protein 2, tetranectin, and soluble receptor for advanced glycation end products. In longitudinal analyses, three proteins were associated with longitudinal change in FEV1 (ΔFEV1) and four with ΔFVC; no proteins were associated with ΔFEV1/FVC.ConclusionOur findings highlight CVD-related plasma proteins that are associated with lung function including markers of inflammation, adiposity, and fibrosis, representing proteins that may contribute both to respiratory and CVD risk.
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- 2022
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23. The relationship between myodural bridges, hyperplasia of the suboccipital musculature, and intracranial pressure.
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Chan Li, Chen Yue, Zhao-Chang Liu, Jin Gong, Xiao-Song Wei, Heng Yang, Campbell Gilmore, Sheng-Bo Yu, Gary D Hack, and Hong-Jin Sui
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Medicine ,Science - Abstract
During mammalian evolution, the Myodural Bridges (MDB) have been shown to be highly conserved anatomical structures. However, the putative physiological function of these structures remains unclear. The MDB functionally connects the suboccipital musculature to the cervical spinal dura mater, while passing through the posterior atlanto-occipital and atlanto-axial interspaces. MDB transmits the tensile forces generated by the suboccipital muscles to the cervical dura mater. Moreover, head movements have been shown to be an important contributor to human CSF circulation. In the present study, a 16-week administration of a Myostatin-specific inhibitor, ACE-031, was injected into the suboccipital musculature of rats to establish an experimental animal model of hyperplasia of the suboccipital musculature. Using an optic fiber pressure measurement instrument, the present authors observed a significant increase in intracranial pressure (ICP) while utilizing the hyperplasia model. In contrast, surgically severing the MDB connections resulted in a significant decrease in intracranial pressure. Thus, these results indicated that muscular activation of the MDB may affect CSF circulation, suggesting a potential functional role of the MDB, and providing a new research perspective on CSF dynamics.
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- 2022
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24. A Tripeptide Diapin Effectively Lowers Blood Glucose Levels in Male Type 2 Diabetes Mice by Increasing Blood Levels of Insulin and GLP-1
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Zhang, Jifeng, primary, Xue, Changyong, additional, Zhu, Tianqing, additional, Vivekanandan, Anuradha, additional, Pennathur, Subramaniam, additional, Ma, Zhongmin Alex, additional, and Chen, Y. Eugene, additional
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- 2013
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25. MCPIP1 Deficiency in Mice Results in Severe Anemia Related to Autoimmune Mechanisms
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Zhou, Zhou, primary, Miao, Ruidong, additional, Huang, Shengping, additional, Elder, Brandon, additional, Quinn, Tim, additional, Papasian, Christopher J., additional, Zhang, Jifeng, additional, Fan, Daping, additional, Chen, Y. Eugene, additional, and Fu, Mingui, additional
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- 2013
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26. Diabetic HDL Is Dysfunctional in Stimulating Endothelial Cell Migration and Proliferation Due to Down Regulation of SR-BI Expression
- Author
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Pan, Bing, primary, Ma, Yijing, additional, Ren, Hui, additional, He, Yubin, additional, Wang, Yongyu, additional, Lv, Xiaofeng, additional, Liu, Donghui, additional, Ji, Liang, additional, Yu, Baoqi, additional, Wang, Yuhui, additional, Chen, Y. Eugene, additional, Pennathur, Subramaniam, additional, Smith, Jonathan D., additional, Liu, George, additional, and Zheng, Lemin, additional
- Published
- 2012
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27. Measurement of Phospholipids May Improve Diagnostic Accuracy in Ovarian Cancer
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Shan, Lian, primary, Chen, Y. Ann, additional, Davis, Lorelei, additional, Han, Gang, additional, Zhu, Weiwei, additional, Molina, Ashley D., additional, Arango, Hector, additional, LaPolla, James P., additional, Hoffman, Mitchell S., additional, Sellers, Thomas, additional, Kirby, Tyler, additional, Nicosia, Santo V., additional, and Sutphen, Rebecca, additional
- Published
- 2012
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28. Biochemical Characterization and Cellular Effects of CADASIL Mutants of NOTCH3
- Author
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Meng, He, primary, Zhang, Xiaojie, additional, Yu, Genggeng, additional, Lee, Soo Jung, additional, Chen, Y. Eugene, additional, Prudovsky, Igor, additional, and Wang, Michael M., additional
- Published
- 2012
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29. Construction of Vascular Tissues with Macro-Porous Nano-Fibrous Scaffolds and Smooth Muscle Cells Enriched from Differentiated Embryonic Stem Cells
- Author
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Hu, Jiang, primary, Xie, Changqing, additional, Ma, Haiyun, additional, Yang, Bo, additional, Ma, Peter X., additional, and Chen, Y. Eugene, additional
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- 2012
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30. Mitochondrial Dysfunction and Adipogenic Reduction by Prohibitin Silencing in 3T3-L1 Cells
- Author
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Liu, Dong, primary, Lin, Yiming, additional, Kang, Ting, additional, Huang, Bo, additional, Xu, Wei, additional, Garcia-Barrio, Minerva, additional, Olatinwo, Moshood, additional, Matthews, Roland, additional, Chen, Y. Eugene, additional, and Thompson, Winston E., additional
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- 2012
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31. Platelet-Derived Growth Factor Induces Rad Expression through Egr-1 in Vascular Smooth Muscle Cells
- Author
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Luo, Yan, primary, Zhang, Meiling, additional, Zhang, Ji, additional, Zhang, Jifeng, additional, Chen, Chunlei, additional, Chen, Y. Eugene, additional, Xiong, Jing-Wei, additional, and Zhu, Xiaojun, additional
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- 2011
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32. Ack1 Mediated AKT/PKB Tyrosine 176 Phosphorylation Regulates Its Activation
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Mahajan, Kiran, primary, Coppola, Domenico, additional, Challa, Sridevi, additional, Fang, Bin, additional, Chen, Y. Ann, additional, Zhu, Weiwei, additional, Lopez, Alexis S., additional, Koomen, John, additional, Engelman, Robert W., additional, Rivera, Charlene, additional, Muraoka-Cook, Rebecca S., additional, Cheng, Jin Q., additional, Schönbrunn, Ernst, additional, Sebti, Said M., additional, Earp, H. Shelton, additional, and Mahajan, Nupam P., additional
- Published
- 2010
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33. SARS-CoV-2 viral shedding characteristics and potential evidence for the priority for faecal specimen testing in diagnosis.
- Author
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Chen Yuan, Hongling Wang, Kefeng Li, An Tang, Yaxin Dai, Bing Wu, Hui Zhang, Jiabei Chen, Jienan Liu, Wenjie Wu, Songye Gu, Hai Wang, Haodi Xu, Mingyu Wu, Menglu Yu, Yuchao Wang, Xinwei Yu, Jialu He, Shelan Liu, Yongli Zhang, Zhendong Tong, and Jianbo Yan
- Subjects
Medicine ,Science - Abstract
This study aimed to identify the specimen type that has high positivity and its proper sampling time for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) testing to promote diagnostic efficiency. All SARS-CoV-2-infected patients with a laboratory-confirmed diagnosis in Zhoushan City were followed up for viral shedding in respiratory tract specimens and faecal samples. Positivity was analysed both qualitatively and quantitatively by proper statistical approaches with strong testing power. Viral shedding in respiratory tract and faecal specimens was prolonged to 45 and 40 days after the last exposure, respectively. The overall positive rate in respiratory tract specimens was low and relatively unstable, being higher in the early-to-mid stage than in the mid-to-late stage of the disease course. Compared with respiratory tract specimens, faecal samples had a higher viral load, higher overall positive rate, and more stable positivity in different disease courses and varied symptomatic status. Faecal specimens have the potential ability to surpass respiratory tract specimens in virus detection. Testing of faecal specimens in diagnosis, especially for identifying asymptomatic carriers, is recommended. Simultaneously, testing respiratory tract specimens at the early-to-mid stage is better than testing at the mid-to-late stage of the disease course. A relatively small sample size was noted, and statistical approaches were used to address it. Information was missing for both specimen types at different stages of the disease course due to censored data. Our research extends the observed viral shedding in both specimen types and highlights the importance of faecal specimen testing in SARS-CoV-2 diagnosis. Healthcare workers, patients, and the general public may all benefit from our study findings. Disposal of sewage from hospitals and residential areas should be performed cautiously because the virus sheds in faeces and can last for a long time.
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- 2021
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34. Evaluation of association studies and a systematic review and meta-analysis of CYP1A1 T3801C and A2455G polymorphisms in breast cancer risk.
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Chen Yang and Xiao-Feng He
- Subjects
Medicine ,Science - Abstract
BackgroundNine previous meta-analyses have been published to analyze the CYP1A1 T3801C and A2455G polymorphisms with BC risk. However, they did not assess the credibility of statistically significant associations. In addition, many new studies have been reported on the above themes. Hence, we conducted an updated systematic review and meta-analysis to further explore the above issues.ObjectivesTo explore the association on the CYP1A1 T3801C and A2455G polymorphisms with BC risk.MethodsPreferred Reporting Items for Systematic Reviews and Meta-Analyses (The PRISMA) were used.ResultsIn this study, there were 63 case-control studies from 56 publications on the CYP1A1 T3801C polymorphism (including 20,825 BC cases and 25,495 controls) and 51 case-control studies from 46 publications on the CYP1A1 A2455G polymorphism (including 20,124 BC cases and 29,183 controls). Overall, the CYP1A1 T3801C polymorphism was significantly increased BC risk in overall analysis, especially in Asians and Indians; the CYP1A1 A2455G polymorphism was associated with BC risk in overall analysis, Indians, and postmenopausal women. However, when we used BFDP correction, associations remained significant only in Indians (CC vs. TT + TC: BFDP < 0.001) for the CYP1A1 T3801C polymorphism with BC risk, but not in the CYP1A1 A2455G polymorphism. In addition, when we further performed sensitivity analysis, no significant association in overall analysis and any subgroup. Moreover, we found that all studies from Indians was low quality. Therefore, the results may be not credible.ConclusionThis meta-analysis strongly indicates that there is no significant association between the CYP1A1 T3801C and A2455G polymorphisms and BC risk. The increased BC risk may most likely on account of false-positive results.
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- 2021
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35. Soil microbial community responses to short-term nitrogen addition in China's Horqin Sandy Land.
- Author
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Niu Yayi, Duan Yulong, Li Yuqiang, Wang Xuyang, Chen Yun, and Wang Lilong
- Subjects
Medicine ,Science - Abstract
Anthropogenic nitrogen (N) addition has increased soil nutrient availability, thereby affecting ecosystem processes and functions in N-limited ecosystems. Long-term N addition decreases plant biodiversity, but the effects of short-term N addition on soil microbial community is poorly understood. The present study examined the impacts of short-term N addition (NH4NO3) on these factors in a sandy grassland and semi-fixed sandy land in the Horqin Sandy Land. We measured the responses of soil microbial biomass C and N; on soil β-1,4-glucosidase (BG) and β-1,4-N-acetylglucosaminidase (NAG) activity; and soil microflora characteristics to N additions gradient with 0 (control), 5 (N5), 10 (N10), and 15 (N15) g N m-2 yr-1. The soil microbial biomass indices, NAG activity, and soil microflora characteristics did not differ significantly among the N levels, and there was no difference at the two sites. The competition for N between plants and soil microbes was not eliminated by short-term N addition due to the low soil nutrient and moisture contents, and the relationships among the original soil microbes did not change. However, N addition increased BG activity in the N5 and N10 additions in the sandy grassland, and in the N5, N10, and N15 additions in the semi-fixed sandy land. This may be due to increased accumulation and fixation of plant litter into soils in response to N addition, leading to increased microbial demand for a C source and increased soil BG activity. Future research should explore the relationships between soil microbial community and N addition at the two sites.
- Published
- 2021
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36. Facile and noninvasive passivation, doping and chemical tuning of macroscopic hybrid perovskite crystals.
- Author
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Ahmad R Kirmani, Ahmed E Mansour, Chen Yang, Rahim Munir, Ahmed M El-Zohry, Omar F Mohammed, and Aram Amassian
- Subjects
Medicine ,Science - Abstract
Halide vacancies and associated metallic lead (Pb°) observed at the surface and deep inside macroscopic organolead trihalide perovskite crystals is removed through a facile and noninvasive treatment. Indeed, Br2 vapor is shown to passivate Br-vacancies and associated Pb° in the bulk of macroscopic crystals. Controlling the exposure time can markedly improve the overall stoichiometry for moderate exposures or introduce excessive bromide for long exposures, resulting in p-doping of the crystals. In the low dose passivation regime, Hall effect measurements reveal a ca. 3-fold increase in carrier mobility to ca. 15 cm2V-1s-1, while the p-doping increases the electrical conductivity ca. 10000-fold, including a 50-fold increase in carrier mobility to ca. 150 cm2V-1s-1. The ease of diffusion of Br2 vapor into macroscopic crystals is ascribed to the porosity allowed in rapidly grown crystals through aggregative processes of the colloidal sol during growth of films and macroscopic crystals. This process is believed to form significant growth defects, including open voids, which may be remnants of the escaping solvent at the solidification front. These results suggest that due to the sol-gel-like nature of the growth process, macroscopic perovskite crystals reported in this study are far from perfect and point to possible pathways to improving the optoelectronic properties of these materials. Nevertheless, the ability of the vapor-phase approach to access and tune the bulk chemistry and properties of nominally macroscopic perovskite crystals provides interesting new opportunities to precisely manipulate and functionalize the bulk properties of hybrid perovskite crystals in a noninvasive manner.
- Published
- 2020
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37. Effects of different fertilization modes on rice yield and quality under a rice-crab culture system.
- Author
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Wanning Zhao, Hanling Liang, Yu Fu, Yubo Liu, Chen Yang, Tian Zhang, Tianyu Wang, Liyan Rong, Shuang Zhang, Zhaoxia Wu, and Wentao Sun
- Subjects
Medicine ,Science - Abstract
Rice-crab culture is the characteristic rice ecological breeding model used in the Panjin area of Liaohe River Basin, China, and it can improve the ecological environment and create increased economic benefits. From a food perspective, both rice yield and quality, which are closely related to the fertilization mode, should be considered. However, the effect of different fertilization modes on rice quality has not been comprehensively investigated in this co-culture system. This study investigated the effects of three fertilization modes(FP1, FP2, and OPT) divided according to different fertilization types and methods on rice yield and quality, and set up a non-fertilized control group. In the rice-crab culture system, FP2 used fewer fertilizers and had a lower economic cost, and the yield was only slightly less than that of OPT(highest yield) but there was no statistical difference. FP2 elicited the best appearance quality and better cooking and eating quality among all treatment modes. Compared with CK, three fertilization modes significantly increased the protein content in rice and decreased the amylose content, which would lead to the deterioration of rice eating quality. However FP2 had the least protein increase and the least amylose reduction. There was no significant change in crude fat and starch content. Therefore, the FP2 fertilization mode was the best choice for the rice-crab culture system, as it significantly improved rice yield and increased rice quality at a relatively low cost.
- Published
- 2020
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38. Nuclear IGF1R interact with PCNA to preserve DNA replication after DNA-damage in a variety of human cancers.
- Author
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Chen Yang, Yifan Zhang, Yi Chen, Franziska Ragaller, Mingzhi Liu, Sara Corvigno, Hanna Dahlstrand, Joseph Carlson, Zihua Chen, Anders Näsman, Ahmed Waraky, Yingbo Lin, Olle Larsson, and Felix Haglund
- Subjects
Medicine ,Science - Abstract
Nuclear IGF1R has been linked to poor outcome in cancer. We recently showed that nuclear IGF1R phosphorylates PCNA and increases DNA damage tolerance. In this paper we aimed to describe this mechanism in cancer tissue as well as in cancer cell lines. In situ proximity ligation assay identified frequent IGF1R and PCNA colocalization in many cancer types. IGF1R/PCNA colocalization was more frequently increased in tumor cells than in adjacent normal, and more prominent in areas with dysplasia and invasion. However, the interaction was often lost in tumors with poor response to neoadjuvant treatment and most metastatic lesions. In two independent cohorts of serous ovarian carcinomas and oropharyngeal squamous cell carcinomas, stronger IGF1R/PCNA colocalization was significantly associated with a higher overall survival. Ex vivo irradiation of ovarian cancer tissue acutely induced IGF1R/PCNA colocalization together with γH2AX-foci formations. In vitro, RAD18 mediated mono-ubiquitination of PCNA during replication stress was dependent on IGF1R kinase activity. DNA fiber analysis revealed that IGF1R activation could rescue stalled DNA replication forks, but only in cancer cells with baseline IGF1R/PCNA interaction. We believe that the IGF1R/PCNA interaction is a basic cellular mechanism to increase DNA stress tolerance during proliferation, but that this mechanism is lost with tumor progression in conjunction with accumulated DNA damage and aberrant strategies to tolerate genomic instability. To exploit this mechanism in IGF1R targeted therapy, IGF1R inhibitors should be explored in the context of concomitant induction of DNA replication stress as well as in earlier clinical stages than previously tried.
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- 2020
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39. Diabetic HDL Is Dysfunctional in Stimulating Endothelial Cell Migration and Proliferation Due to Down Regulation of SR-BI Expression.
- Author
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Bing Pan, Yijing Ma, Hui Ren, Yubin He, Yongyu Wang, Xiaofeng Lv, Donghui Liu, Liang Ji, Baoqi Yu, Yuhui Wang, Chen, Y. Eugene, Pennathur, Subramaniam, Smith, Jonathan D., Liu, George, and Zheng, Lemin
- Subjects
STEM cell research ,INSECTS ,OVARIES ,DROSOPHILA melanogaster ,DROSOPHILA ,CELLS ,LARVAE - Abstract
Background: Diabetic HDL had diminished capacity to stimulate endothelial cell (EC) proliferation, migration, and adhesion to extracellular matrix. The mechanism of such dysfunction is poorly understood and we therefore sought to determine the mechanistic features of diabetic HDL dysfunction. Methodology/Principal Findings: We found that the dysfunction of diabetic HDL on human umbilical vein endothelial cells (HUVECs) was associated with the down regulation of the HDL receptor protein, SR-BI. Akt-phosphorylation in HUVECs was induced in a biphasic manner by normal HDL. While diabetic HDL induced Akt phosphorylation normally after 20 minutes, the phosphorylation observed 24 hours after diabetic HDL treatment was reduced. To determine the role of SR-BI down regulation on diminished EC responses of diabetic HDL, Mouse aortic endothelial cells (MAECs) were isolated from wild type and SR-BI (2/2) mice, and treated with normal and diabetic HDL. The proliferative and migratory effects of normal HDL on wild type MAECs were greatly diminished in SR-BI (2/2) cells. In contrast, response to diabetic HDL was impaired in both types suggesting diminished effectiveness of diabetic HDL on EC proliferation and migration might be due to the down regulation of SR-BI. Additionally, SR-BI down regulation diminishes diabetic HDL's capacity to activate Akt chronically. Conclusions/Significance: Diabetic HDL was dysfunctional in promoting EC proliferation, migration, and adhesion to matrix which was associated with the down-regulation of SR-BI. Additionally, SR-BI down regulation diminishes diabetic HDL's capacity to activate Akt chronically. [ABSTRACT FROM AUTHOR]
- Published
- 2012
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40. Measurement of Phospholipids May Improve Diagnostic Accuracy in Ovarian Cancer.
- Author
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Lian Shan, Chen, Y. Ann, Davis, Lorelei, Gang Han, Weiwei Zhu, Molina, Ashley D., Arango, Hector, LaPolla, James P., Hoffman, Mitchell S., Sellers, Thomas, Kirby, Tyler, Nicosia, Santo V., and Sutphen, Rebecca
- Subjects
- *
SURGERY , *OVARIAN tumors , *PHOSPHOLIPIDS , *OVARIAN cancer , *WOMEN , *MASS spectrometry - Abstract
Background: More than two-thirds of women who undergo surgery for suspected ovarian neoplasm do not have cancer. Our previous results suggest phospholipids as potential biomarkers of ovarian cancer. In this study, we measured the serum levels of multiple phospholipids among women undergoing surgery for suspected ovarian cancer to identify biomarkers that better predict whether an ovarian mass is malignant. Methodology/Principal Findings: We obtained serum samples preoperatively from women with suspected ovarian cancer enrolled through a prospective, population-based rapid ascertainment system. Samples were analyzed from all women in whom a diagnosis of epithelial ovarian cancer (EOC) was confirmed and from benign disease cases randomly selected from the remaining (non-EOC) samples. We measured biologically relevant phospholipids using liquid chromatography/ electrospray ionization mass spectrometry. We applied a powerful statistical and machine learning approach, Hybrid huberized support vector machine (HH-SVM) to prioritize phospholipids to enter the biomarker models, and used crossvalidation to obtain conservative estimates of classification error rates. Results: The HH-SVM model using the measurements of specific combinations of phospholipids supplements clinical CA125 measurement and improves diagnostic accuracy. Specifically, the measurement of phospholipids improved sensitivity (identification of cases with preoperative CA125 levels below 35) among two types of cases in which CA125 performance is historically poor - early stage cases and those of mucinous histology. Measurement of phospholipids improved the identification of early stage cases from 65% (based on CA125) to 82%, and mucinous cases from 44% to 88%. Conclusions/Significance: Levels of specific serum phospholipids differ between women with ovarian cancer and those with benign conditions. If validated by independent studies in the future, these biomarkers may serve as an adjunct at the time of clinical presentation, to distinguish between women with ovarian cancer and those with benign conditions with shared symptoms and features. [ABSTRACT FROM AUTHOR]
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- 2012
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41. Biochemical Characterization and Cellular Effects of CADASIL Mutants of NOTCH3.
- Author
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He Meng, Xiaojie Zhang, Genggeng Yu, Soo Jung Lee, Chen, Y. Eugene, Prudovsky, Igor, Wang, Michael M., and Huaibin Cai
- Subjects
SMOOTH muscle ,CELL culture ,STROKE ,PROTEIN research ,MUSCLE cells ,CYTOLOGICAL research - Abstract
Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL) is the best understood cause of dominantly inherited stroke and results from NOTCH3 mutations that lead to NOTCH3 protein accumulation and selective arterial smooth muscle degeneration. Previous studies show that NOTCH3 protein forms multimers. Here, we investigate protein interactions between NOTCH3 and other vascular Notch isoforms and characterize the effects of elevated NOTCH3 on smooth muscle gene regulation. We demonstrate that NOTCH3 forms heterodimers with NOTCH1, NOTCH3, and NOTCH4. R90C and C49Y mutant NOTCH3 form complexes which are more resistant to detergents than wild type NOTCH3 complexes. Using quantitative NOTCH3-luciferase clearance assays, we found significant inhibition of mutant NOTCH3 clearance. In coculture assays of NOTCH function, overexpressed wild type and mutant NOTCH3 significantly repressed NOTCH-regulated smooth muscle transcripts and potently impaired the activity of three independent smooth muscle promoters. Wildtype and R90C recombinant NOTCH3 proteins applied to cell cultures also blocked canonical Notch fuction. We conclude that CADASIL mutants of NOTCH3 complex with NOTCH1, 3, and 4, slow NOTCH3 clearance, and that overexpressed wild type and mutant NOTCH3 protein interfere with key NOTCH-mediated functions in smooth muscle cells. [ABSTRACT FROM AUTHOR]
- Published
- 2012
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42. Construction of Vascular Tissues with Macro-Porous Nano-Fibrous Scaffolds and Smooth Muscle Cells Enriched from Differentiated Embryonic Stem Cells.
- Author
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Jiang Hu, Changqing Xie, Haiyun Ma, Bo Yang, Ma, Peter X., and Chen, Y. Eugene
- Subjects
MUSCLE cells ,BLOOD vessels ,EMBRYONIC stem cells ,TISSUE engineering ,TRETINOIN ,STEM cells - Abstract
Vascular smooth muscle cells (SMCs) have been broadly used for constructing tissue-engineered blood vessels. However, the availability of mature SMCs from donors or patients is very limited. Derivation of SMCs by differentiating embryonic stem cells (ESCs) has been reported, but not widely utilized in vascular tissue engineering due to low induction efficiency and, hence, low SMC purity. To address these problems, SMCs were enriched from retinoic acid induced mouse ESCs with LacZ genetic labeling under the control of SM22α promoter as the positive sorting marker in the present study. The sorted SMCs were characterized and then cultured on three-dimensional macro-porous nano-fibrous scaffolds in vitro or implanted subcutaneously into nude mice after being seeded on the scaffolds. Our data showed that the LacZ staining, which reflected the corresponding SMC marker SM22α expression level, was efficient as a positive selection marker to dramatically enrich SMCs and eliminate other cell types. After the sorted cells were seeded into the three-dimensional nano-fibrous scaffolds, continuous retinoic acid treatment further enhanced the SMC marker gene expression level while inhibited pluripotent maker gene expression level during the in vitro culture. Meanwhile, after being implanted subcutaneously into nude mice, the implanted cells maintained the positive LacZ staining within the constructs and no teratoma formation was observed. In conclusion, our results demonstrated the potential of SMCs derived from ESCs as a promising cell source for therapeutic vascular tissue engineering and disease model applications. [ABSTRACT FROM AUTHOR]
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- 2012
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43. Mitochondrial Dysfunction and Adipogenic Reduction by Prohibitin Silencing in 3T3-L1 Cells.
- Author
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Dong Liu, Yiming Lin, Ting Kang, Bo Huang, Wei Xu, Garcia-Barrio, Minerva, Olatinwo, Moshood, Matthews, Roland, Chen, Y. Eugene, and Thompson, Winston E.
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MITOCHONDRIA ,ORIGIN of life ,BIOMOLECULES ,PROTOPLASM ,NUTRITION disorders ,FAT cells ,METABOLIC disorders - Abstract
Increase in mitochondrial biogenesis has been shown to accompany brown and white adipose cell differentiation. Prohibitins (PHBs), comprised of two evolutionarily conserved proteins, prohibitin-1 (PHB1) and prohibitin-2 (PHB2), are present in a high molecular-weight complex in the inner membrane of mitochondria. However, little is known about the effect of mitochondrial PHBs in adipogenesis. In the present study, we demonstrate that the levels of both PHB1 and PHB2 are significantly increased during adipogenesis of 3T3-L1 preadipocytes, especially in mitochondria. Knockdown of PHB1 or PHB2 by oligonucleotide siRNA significantly reduced the expression of adipogenic markers, the accumulation of lipids and the phosphorylation of extracellular signal-regulated kinases. In addition, fragmentation of mitochondrial reticulum, loss of mitochondrial cristae, reduction of mitochondrial content, impairment of mitochondrial complex I activity and excessive production of ROS were observed upon PHB-silencing in 3T3-L1 cells. Our results suggest that PHBs are critical mediators in promoting 3T3-L1 adipocyte differentiation and may be the potential targets for obesity therapies. [ABSTRACT FROM AUTHOR]
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- 2012
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44. Platelet-Derived Growth Factor Induces Rad Expression through Egr-1 in Vascular Smooth Muscle Cells.
- Author
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Yan Luo, Meiling Zhang, Ji Zhang, Jifeng Zhang, Chunlei Chen, Chen, Y. Eugene, Jing-Wei Xiong, and Xiaojun Zhu
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DIABETES ,PLATELET-derived growth factor ,VASCULAR smooth muscle ,MUSCLE cells ,CELLULAR control mechanisms ,CELL migration ,TRANSCRIPTION factors ,GENE expression - Abstract
Background: Ras associated with diabetes (Rad) inhibits vascular lesion formation by reducing the attachment and migration of vascular smooth muscle cells (VSMCs). However, the transcriptional regulation of Rad in VSMCs is unclear. Methodology and Principal Findings: We found that Platelet-Derived Growth Factor (PDGF)induced Rad expression in a time- and dose-dependent manner in rat aortic smooth muscle cells (RASMCs) using quantitative real-time PCR. By serial deletion analysis of the Rad promoter, we identified that two GC-rich early growth response-1 (Egr-1) binding sites are essential for PDGF-induced Rad promoter activation. Overexpression of Egr-1 in RASMCs strongly stimulated Rad expression while the Egr-1 corepressor, NGFI-A binding protein 2 (NAB2), repressed PDGF-induced Rad up-regulation in a dose-dependent manner. Direct binding of Egr-1 to the Rad promoter region was further confirmed by chromatin immunoprecipitation assays. Conclusions: Our results demonstrate that Rad is regulated by PDGF through the transcriptional factor Egr-1 in RASMCs. [ABSTRACT FROM AUTHOR]
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- 2011
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45. Estimation of intravoxel incoherent motion parameters using low b-values.
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Chen Ye, Daoyun Xu, Yongbin Qin, Lihui Wang, Rongpin Wang, Wuchao Li, Zixiang Kuai, and Yuemin Zhu
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Medicine ,Science - Abstract
Intravoxel incoherent motion (IVIM) imaging is a magnetic resonance imaging (MRI) technique widely used in clinical applications for various organs. However, IVIM imaging at low b-values is a persistent problem. This paper aims to investigate in a systematic and detailed manner how the number of low b-values influences the estimation of IVIM parameters. To this end, diffusion-weighted (DW) data with different low b-values were simulated to get insight into the distributions of subsequent IVIM parameters. Then, in vivo DW data with different numbers of low b-values and different number of excitations (NEX) were acquired. Finally, least-squares (LSQ) and Bayesian shrinkage prior (BSP) fitting methods were implemented to estimate IVIM parameters. The influence of the number of low b-values on IVIM parameters was analyzed in terms of relative error (RE) and structural similarity (SSIM). The results showed that the influence of the number of low b-values on IVIM parameters is variable. LSQ is more dependent on the number of low b-values than BSP, but the latter is more sensitive to noise.
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- 2019
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46. Effects of different fatigue locations on upper body kinematics and inter-joint coordination in a repetitive pointing task.
- Author
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Chen Yang, Samuel Leitkam, and Julie N Côté
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Medicine ,Science - Abstract
Studies have shown that muscle fatigue can lead to posture, joint angle, inter-joint coordination and variability alterations. However, the three-dimensional kinematic effects of localized muscular fatigue on a multijoint movement remain unclear. Healthy young adults (N = 17, 10 females) performed a standing repetitive pointing task when they were non-fatigued, and after localized muscle fatigue was induced at the elbow, the shoulder, and the trunk using isometric protocols performed until exhaustion. Joint angles and angular standard deviation (SD) of trunk, shoulder and elbow, and continuous relative phase (CRP) and CRP SD between trunk and shoulder, and shoulder and elbow were computed and compared between fatigue conditions. Results showed that trunk lateral flexion SD increased after fatigue of the elbow (0.1°, p = 0.04), shoulder (0.1°, p = 0.04) and trunk (0.1°, p
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- 2019
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47. Live-attenuated H1N1 influenza vaccine candidate displays potent efficacy in mice and ferrets.
- Author
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Charles B Stauft, Chen Yang, J Robert Coleman, David Boltz, Chiahsuan Chin, Anna Kushnir, and Steffen Mueller
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Medicine ,Science - Abstract
Currently, influenza vaccine manufacturers need to produce 1-5 x 107 PFU of each vaccine strain to fill one dose of the current live-attenuated-influenza-vaccine (LAIV). To make a single dose of inactivated vaccine (15 ug of each hemagglutinin), the equivalent of 1010 PFU of each vaccine strains need to be grown. This high dose requirement is a major drawback for manufacturing as well as rapidly sourcing sufficient doses during a pandemic. Using our computer-aided vaccine platform Synthetic Attenuated Virus Engineering (SAVE), we created a vaccine candidate against pandemic H1N1 A/CA/07/2009 (CodaVax-H1N1) with robust efficacy in mice and ferrets, and is protective at a much lower dose than the current LAIV. CodaVax-H1N1 is currently in Phase I/II clinical trials. The hemagglutinin (HA) and neuraminidase (NA) gene segments of A/California/07/2009 (H1N1) (CA07) were "de-optimized" and a LAIV was generated ex silico using DNA synthesis. In DBA/2 mice, vaccination at a very low dose (100 or approximately 1 PFU) with CodaVax-H1N1 prevented disease after lethal challenge with wild-type H1N1. In BALB/c mice, as little as 103 PFU was protective against lethal challenge with mouse-adapted H1N1. In ferrets, CodaVax-H1N1 was more potent compared to currently licensed LAIV and still effective at a low dose of 103 PFU at preventing replication of challenge virus.
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- 2019
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48. The efficacy and safety of targeted therapy plus fulvestrant in postmenopausal women with hormone-receptor positive advanced breast cancer: A meta-analysis of randomized-control trials.
- Author
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Gao Chanchan, Su Xiangyu, Shi Fangfang, Chen Yan, and Gu Xiaoyi
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Medicine ,Science - Abstract
OBJECTIVE:To evaluate the efficacy and safety of targeted therapy plus fulvestrant for postmenopausal patients with hormone receptor-positive advanced breast cancer. METHODS:Pubmed, Embase and Web of Science databases were systematically searched on February 26, 2018. Eligible studies were screened according to selection criteria, and two reviewers independently extracted outcome data which included progression-free survival, overall survival, objective response rate, clinical benefit rate and toxicities. RevMan 5.3 and STATA 11.0 software were used to conduct meta-analysis. RESULTS:Thirteen articles including twelve randomized-control trials fulfilled selection criteria. There was no evidence regarding the existence of publication bias and high-risk bias of quality in the selected studies. In previously endocrine therapy-treated postmenopausal patients with hormone-receptor positive advanced breast cancer, the PFS (HR = 0.77, 95%CI: 0.66-0.91) and ORR (RR = 1.78, 95%CI: 1.35-2.34) of combination therapy group were significantly higher than that from fulvestrant monotherapy group. Besides, a statistically significant difference in PFS was found across the two arms in postmenopausal women with PIK3CA-mutant ctDNA tumor (HR = 0.52, 95% CI: 0.39-0.69). Moreover, the risk of adverse events (RR = 1.09, 95%CI: 1.05-1.13), CTCAE≥3 (RR = 1.97, 95%CI: 1.49-2.60) and discontinuation due to adverse events (RR = 4.91, 95%CI: 3.37-7.15) were also significantly different between two treatment groups. Sensitivity analysis showed PLOMA-3 trial was an important factor of heterogeneity. DISCUSSION:Even though the combination of targeted therapy plus fulvestrant improved PFS and increased ORR in advanced breast cancer patients, the toxicities of combination therapy were also higher than fulvestrant monotherapy. Further studies related to inhibitors targeting the specific signaling pathway or receptors are urgently needed, and more efforts concerning precision medicine of targeted therapy plus endocrine therapy should be taken to improve the clinical benefits.
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- 2018
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49. Using the RIGHT statement to evaluate the reporting quality of clinical practice guidelines in traditional Chinese medicine.
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Xia Yun, Chen Yaolong, Zeng Zhao, Zhou Qi, Wang Yangyang, Xie Runshen, Xie Xiuli, and Li Hui
- Subjects
Medicine ,Science - Abstract
OBJECTIVE:To evaluate the reporting quality of clinical practice guidelines (CPGs) in traditional Chinese medicine (TCM). METHODS:A systematic search was undertaken to extract CPGs for TCM. The RIGHT (Reporting Items for practice Guidelines in Healthcare) statement was used to calculate scores for the reporting quality in terms of domains and items, followed by a subgroup analysis of the results and determination of the correlation between the RIGHT and AGREE II (Appraisal of Guidelines for Research and Evaluation II) scores. RESULTS:Overall, 539 TCM CPGs were included. (1) The mean scores (Med, IQR) for each RIGHT domain were as follows: basic information (4, 1), background (3, 2), evidence (0, 0), recommendations (2, 2), review and quality assurance (0, 0), funding and declaration and management of interests (0, 0.5), and other information (0, 0). (2) The items with a low reporting rate ( 90%) included 1a, 1b, 1c, 7b, 13a, and 13b. (3) In recent years, the reporting quality of TCM CPGs has improved, and there was a significant difference among the organizations (P = 0.000), where that of the updated versions was greater than that of the historical versions (P = 0.047). (4) The RIGHT and AGREE II scores were positively correlated (P = 0.014). CONCLUSIONS:At present, although the reporting quality of TCM CPGs is improving, the overall quality remains suboptimal. Guideline developers should strictly follow the evidence-based process of developing guidelines and should follow the RIGHT statement to produce a standardized report when writing guidelines.
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- 2018
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50. Fluoride Regulate Osteoblastic Transforming Growth Factor-β1 Signaling by Mediating Recycling of the Type I Receptor ALK5.
- Author
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Chen Yang, Yan Wang, and Hui Xu
- Subjects
Medicine ,Science - Abstract
This study aimed to preliminary investigate the role of activin receptor-like kinase (ALK) 5 as one of TGF-βR1 subtypes in bone turnover and osteoblastic differentiation induced by fluoride. We analyzed bone mineral density and the expression of genes related with transforming growth factor-β1(TGF-β1) signaling and bone turnover in rats treated by different concentrations of fluoride with or without SB431542 in vivo. Moreover, MTT assay, alkaline phosphatase staining, RT-PCR, immunocytochemical analysis and western blot analysis were used to detect the influence on bone marrow stem cells (BMSC) after stimulating by varying concentration of fluoride with or without SB431542 in vitro. The in vivo study showed SB431542 treatment affected bone density and gene expression of rats, which indicated TGF-β1 and ALK5 might take part in fluoride-induced bone turnover and bone formation. The in vitro study showed low concentration of fluoride improved BMSC cells viability, alkaline phosphatase activity, and osteocalcin protein expression which were inhibited by high concentration of fluoride. The gene expression of Runx2 and ALK5 in cells increased after low concentration fluoride treatment which was also inhibited by high concentration of fluoride. Fluoride treatment inhibited gene and protein expression of Samd3 (except 1 mgF-/L). Compared with fluoride treatment alone, cells differentiation was inhibited with SB431542 treatment. Moreover, the expression of Runx2, ALK5 and Smad3 were influenced by SB431542 treatment. In conclusion, this preliminary study indicated that fluoride regulated osteoblastic TGFβ1 signaling in bone turnover and cells differentiation via ALK5.
- Published
- 2017
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