Search

Your search keyword '"Jones, Kathryn"' showing total 9 results
Start Over Author "Jones, Kathryn" Journal plos neglected tropical diseases
9 results on '"Jones, Kathryn"'

5. Trypanosoma cruzi vaccine candidate antigens Tc24 and TSA-1 recall memory immune response associated with HLA-A and -B supertypes in Chagasic chronic patients from Mexico

Author

Villanueva-Lizama, Liliana E., primary, Cruz-Chan, Julio V., additional, Aguilar-Cetina, Amarú del C., additional, Herrera-Sanchez, Luis F., additional, Rodriguez-Perez, Jose M., additional, Rosado-Vallado, Miguel E., additional, Ramirez-Sierra, Maria J., additional, Ortega-Lopez, Jaime, additional, Jones, Kathryn, additional, Hotez, Peter, additional, Bottazzi, Maria Elena, additional, and Dumonteil, Eric, additional

Published
2018
Full Text
View/download PDF

6. Yeast-expressed recombinant As16 protects mice against Ascaris suum infection through induction of a Th2-skewed immune response

Author

Wei, Junfei, primary, Versteeg, Leroy, additional, Liu, Zhuyun, additional, Keegan, Brian, additional, Gazzinelli-Guimarães, Ana Clara, additional, Fujiwara, Ricardo T., additional, Briggs, Neima, additional, Jones, Kathryn M., additional, Strych, Ulrich, additional, Beaumier, Coreen M., additional, Bottazzi, Maria Elena, additional, Hotez, Peter J., additional, and Zhan, Bin, additional

Published
2017
Full Text
View/download PDF

7. One Health Interactions of Chagas Disease Vectors, Canid Hosts, and Human Residents along the Texas-Mexico Border

Author

Garcia, Melissa N., primary, O’Day, Sarah, additional, Fisher-Hoch, Susan, additional, Gorchakov, Rodion, additional, Patino, Ramiro, additional, Feria Arroyo, Teresa P., additional, Laing, Susan T., additional, Lopez, Job E., additional, Ingber, Alexandra, additional, Jones, Kathryn M., additional, and Murray, Kristy O., additional

Published
2016
Full Text
View/download PDF

9. Mechanistic and Single-Dose In Vivo Therapeutic Studies of Cry5B Anthelmintic Action against Hookworms

Author

Hu, Yan, Zhan, Bin, Keegan, Brian, Yiu, Ying Y., Miller, Melanie M., Jones, Kathryn, and Aroian, Raffi V.

Subjects
ANTHELMINTICS, HOOKWORMS, PARASITIC diseases, MALARIA, HELMINTHS, BACILLUS thuringiensis, CAENORHABDITIS elegans
Abstract

Background: Hookworm infections are one of the most important parasitic infections of humans worldwide, considered by some second only to malaria in associated disease burden. Single-dose mass drug administration for soil-transmitted helminths, including hookworms, relies primarily on albendazole, which has variable efficacy. New and better hookworm therapies are urgently needed. Bacillus thuringiensis crystal protein Cry5B has potential as a novel anthelmintic and has been extensively studied in the roundworm Caenorhabditis elegans. Here, we ask whether single-dose Cry5B can provide therapy against a hookworm infection and whether C. elegans mechanism-of-action studies are relevant to hookworms. Methodology/Principal Findings: To test whether the C. elegans invertebrate-specific glycolipid receptor for Cry5B is relevant in hookworms, we fed Ancylostoma ceylanicum hookworm adults Cry5B with and without galactose, an inhibitor of Cry5B-C. elegans glycolipid interactions. As with C. elegans, galactose inhibits Cry5B toxicity in A. ceylanicum. Furthermore, p38 mitogen-activated protein kinase (MAPK), which controls one of the most important Cry5B signal transduction responses in C. elegans, is functionally operational in hookworms. A. ceylanicum hookworms treated with Cry5B up-regulate p38 MAPK and knock down of p38 MAPK activity in hookworms results in hypersensitivity of A. ceylanicum adults to Cry5B attack. Single-dose Cry5B is able to reduce by >90% A. ceylanicum hookworm burdens from infected hamsters, in the process eliminating hookworm egg shedding in feces and protecting infected hamsters from blood loss. Anthelmintic activity is increased about 3-fold, eliminating >97% of the parasites with a single 3 mg dose (∼30 mg/kg), by incorporating a simple formulation to help prevent digestion in the acidic stomach of the host mammal. Conclusions/Significance: These studies advance the development of Cry5B protein as a potent, safe single-dose anthelmintic for hookworm therapy and make available the information of how Cry5B functions in C. elegans in order to study and improve Cry5B function against hookworms. [ABSTRACT FROM AUTHOR]

Published
2012
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results