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Start Over Author "Hirayama Kenji" Journal plos neglected tropical diseases
22 results on '"Hirayama Kenji"'

1. Correction: Dynamics of serological responses to defined recombinant proteins during Schistosoma mansoni infection in mice before and after the treatment with praziquantel

Author

Mohammed, Eman Sayed, primary, Nakamura, Risa, additional, Kalenda, Yombo DJ, additional, Deloer, Sharmina, additional, Moriyasu, Taeko, additional, Tanaka, Mio, additional, Fujii, Yoshito, additional, Kaneko, Satoshi, additional, Hirayama, Kenji, additional, Ibrahim, Ahmed I., additional, El-Seify, Mahmoud A., additional, Metwally, Asmaa M., additional, and Hamano, Shinjiro, additional

Published
2022
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2. Correction: Predictive markers for the early prognosis of dengue severity: A systematic review and meta-analysis

Author

Thach, Tran Quang, primary, Eisa, Heba Gamal, additional, Hmeda, AlMotsim Ben, additional, Faraj, Hazem, additional, Thuan, Tieu Minh, additional, Abdelrahman, Manal Mahmoud, additional, Awadallah, Mario Gerges, additional, Ha, Nam Xuan, additional, Noeske, Michael, additional, Abdul Aziz, Jeza Muhamad, additional, Nam, Nguyen Hai, additional, Nile, Mohamed El, additional, Dumre, Shyam Prakash, additional, Huy, Nguyen Tien, additional, and Hirayama, Kenji, additional

Published
2022
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3. Predictive markers for the early prognosis of dengue severity: A systematic review and meta-analysis

Author

Thach, Tran Quang, primary, Eisa, Heba Gamal, additional, Hmeda, AlMotsim Ben, additional, Faraj, Hazem, additional, Thuan, Tieu Minh, additional, Abdelrahman, Manal Mahmoud, additional, Awadallah, Mario Gerges, additional, Ha, Nam Xuan, additional, Noeske, Michael, additional, Abdul Aziz, Jeza Muhamad, additional, Nam, Nguyen Hai, additional, Nile, Mohamed El, additional, Dumre, Shyam Prakash, additional, Huy, Nguyen Tien, additional, and Hirayama, Kenji, additional

Published
2021
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4. Dynamics of serological responses to defined recombinant proteins during Schistosoma mansoni infection in mice before and after the treatment with praziquantel

Author

Mohammed, Eman Sayed, primary, Nakamura, Risa, additional, Kalenda, Yombo DJ, additional, Deloer, Sharmina, additional, Moriyasu, Taeko, additional, Tanaka, Mio, additional, Fujii, Yoshito, additional, Kaneko, Satoshi, additional, Hirayama, Kenji, additional, Ibrahim, Ahmed I., additional, El-Seify, Mahmoud A., additional, Metwally, Asmaa M., additional, and Hamano, Shinjiro, additional

Published
2020
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5. IL-17A, a possible biomarker for the evaluation of treatment response in Trypanosoma cruzi infected children: A 12-months follow-up study in Bolivia

Author

Vásquez Velásquez, Clara, primary, Russomando, Graciela, additional, Espínola, Emilio E., additional, Sanchez, Zunilda, additional, Mochizuki, Kota, additional, Roca, Yelin, additional, Revollo, Jimmy, additional, Guzman, Angelica, additional, Quiroga, Benjamín, additional, Rios Morgan, Susana, additional, Vargas Ortiz, Roberto, additional, Zambrana Ortega, Alberto, additional, Espinoza, Eida, additional, Nishizawa, Juan Eiki, additional, Kamel, Mohamed Gomaa, additional, Kikuchi, Mihoko, additional, Mizukami, Shusaku, additional, Na-Bangchang, Kesara, additional, Tien Huy, Nguyen, additional, and Hirayama, Kenji, additional

Published
2019
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6. Spatial distribution and risk factors of Schistosoma haematobium and hookworm infections among schoolchildren in Kwale, Kenya

Author

Chadeka, Evans Asena, primary, Nagi, Sachiyo, additional, Sunahara, Toshihiko, additional, Cheruiyot, Ngetich Benard, additional, Bahati, Felix, additional, Ozeki, Yuriko, additional, Inoue, Manabu, additional, Osada-Oka, Mayuko, additional, Okabe, Mayuko, additional, Hirayama, Yukio, additional, Changoma, Mwatasa, additional, Adachi, Keishi, additional, Mwende, Faith, additional, Kikuchi, Mihoko, additional, Nakamura, Risa, additional, Kalenda, Yombo Dan Justin, additional, Kaneko, Satoshi, additional, Hirayama, Kenji, additional, Shimada, Masaaki, additional, Ichinose, Yoshio, additional, Njenga, Sammy M., additional, Matsumoto, Sohkichi, additional, and Hamano, Shinjiro, additional

Published
2017
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7. Post-dengue acute disseminated encephalomyelitis: A case report and meta-analysis

Author

Kamel, Mohamed Gomaa, primary, Nam, Nguyen Tran, additional, Han, Nguyen Huu Bao, additional, El-Shabouny, Abd-Elaziz, additional, Makram, Abd-ElRahman Mohamed, additional, Abd-Elhay, Fatma Abd-Elshahed, additional, Dang, Tran Ngoc, additional, Hieu, Nguyen Le Trung, additional, Huong, Vu Thi Que, additional, Tung, Trinh Huu, additional, Hirayama, Kenji, additional, and Huy, Nguyen Tien, additional

Published
2017
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9. A Proteomic Approach Identifies Candidate Early Biomarkers to Predict Severe Dengue in Children

Author

Nhi, Dang My, primary, Huy, Nguyen Tien, additional, Ohyama, Kaname, additional, Kimura, Daisuke, additional, Lan, Nguyen Thi Phuong, additional, Uchida, Leo, additional, Thuong, Nguyen Van, additional, Nhon, Cao Thi My, additional, Phuc, Le Hong, additional, Mai, Nguyen Thi, additional, Mizukami, Shusaku, additional, Bao, Lam Quoc, additional, Doan, Nguyen Ngoc, additional, Binh, Nguyen Van Thanh, additional, Quang, Luong Chan, additional, Karbwang, Juntra, additional, Yui, Katsuyuki, additional, Morita, Kouichi, additional, Huong, Vu Thi Que, additional, and Hirayama, Kenji, additional

Published
2016
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10. Species-Specific Serological Detection for Schistosomiasis by Serine Protease Inhibitor (SERPIN) in Multiplex Assay

Author

Tanigawa, Chihiro, primary, Fujii, Yoshito, additional, Miura, Masashi, additional, Nzou, Samson Muuo, additional, Mwangi, Anne Wanjiru, additional, Nagi, Sachiyo, additional, Hamano, Shinjiro, additional, Njenga, Sammy M., additional, Mbanefo, Evaristus Chibunna, additional, Hirayama, Kenji, additional, Mwau, Matilu, additional, and Kaneko, Satoshi, additional

Published
2015
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12. Serological Surveillance Development for Tropical Infectious Diseases Using Simultaneous Microsphere-Based Multiplex Assays and Finite Mixture Models

Author

Fujii, Yoshito, primary, Kaneko, Satoshi, additional, Nzou, Samson Muuo, additional, Mwau, Matilu, additional, Njenga, Sammy M., additional, Tanigawa, Chihiro, additional, Kimotho, James, additional, Mwangi, Anne Wanjiru, additional, Kiche, Ibrahim, additional, Matsumoto, Sohkichi, additional, Niki, Mamiko, additional, Osada-Oka, Mayuko, additional, Ichinose, Yoshio, additional, Inoue, Manabu, additional, Itoh, Makoto, additional, Tachibana, Hiroshi, additional, Ishii, Kazunari, additional, Tsuboi, Takafumi, additional, Yoshida, Lay Myint, additional, Mondal, Dinesh, additional, Haque, Rashidul, additional, Hamano, Shinjiro, additional, Changoma, Mwatasa, additional, Hoshi, Tomonori, additional, Kamo, Ken-ichi, additional, Karama, Mohamed, additional, Miura, Masashi, additional, and Hirayama, Kenji, additional

Published
2014
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13. Characterization of a Gene Family Encoding SEA (Sea-urchin Sperm Protein, Enterokinase and Agrin)-Domain Proteins with Lectin-Like and Heme-Binding Properties from Schistosoma japonicum

Author

Mbanefo, Evaristus Chibunna, primary, Kikuchi, Mihoko, additional, Huy, Nguyen Tien, additional, Shuaibu, Mohammed Nasir, additional, Cherif, Mahamoud Sama, additional, Yu, Chuanxin, additional, Wakao, Masahiro, additional, Suda, Yasuo, additional, and Hirayama, Kenji, additional

Published
2014
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15. Protective Human Leucocyte Antigen Haplotype, HLA-DRB1*01-B*14, against Chronic Chagas Disease in Bolivia

Author

del Puerto, Florencia, primary, Nishizawa, Juan Eiki, additional, Kikuchi, Mihoko, additional, Roca, Yelin, additional, Avilas, Cinthia, additional, Gianella, Alberto, additional, Lora, Javier, additional, Velarde, Freddy Udalrico Gutierrez, additional, Miura, Sachio, additional, Komiya, Norihiro, additional, Maemura, Koji, additional, and Hirayama, Kenji, additional

Published
2012
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16. Association of Mast Cell-Derived VEGF and Proteases in Dengue Shock Syndrome

Author

Furuta, Takahisa, primary, Murao, Lyre Anni, additional, Lan, Nguyen Thi Phuong, additional, Huy, Nguyen Tien, additional, Huong, Vu Thi Que, additional, Thuy, Tran Thi, additional, Tham, Vo Dinh, additional, Nga, Cao Thi Phi, additional, Ha, Tran Thi Ngoc, additional, Ohmoto, Yasukazu, additional, Kikuchi, Mihoko, additional, Morita, Kouichi, additional, Yasunami, Michio, additional, Hirayama, Kenji, additional, and Watanabe, Naohiro, additional

Published
2012
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17. Lineage Analysis of Circulating Trypanosoma cruzi Parasites and Their Association with Clinical Forms of Chagas Disease in Bolivia

Author

del Puerto, Ramona, primary, Nishizawa, Juan Eiki, additional, Kikuchi, Mihoko, additional, Iihoshi, Naomi, additional, Roca, Yelin, additional, Avilas, Cinthia, additional, Gianella, Alberto, additional, Lora, Javier, additional, Gutierrez Velarde, Freddy Udalrico, additional, Renjel, Luis Alberto, additional, Miura, Sachio, additional, Higo, Hiroo, additional, Komiya, Norihiro, additional, Maemura, Koji, additional, and Hirayama, Kenji, additional

Published
2010
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18. Protective and Enhancing HLA Alleles, HLA-DRB1*0901 and HLA-A*24, for Severe Forms of Dengue Virus Infection, Dengue Hemorrhagic Fever and Dengue Shock Syndrome

Author

Lan, Nguyen Thi Phuong, primary, Kikuchi, Mihoko, additional, Huong, Vu Thi Que, additional, Ha, Do Quang, additional, Thuy, Tran Thi, additional, Tham, Vo Dinh, additional, Tuan, Ha Manh, additional, Tuong, Vo Van, additional, Nga, Cao Thi Phi, additional, Van Dat, Tran, additional, Oyama, Toshifumi, additional, Morita, Kouichi, additional, Yasunami, Michio, additional, and Hirayama, Kenji, additional

Published
2008
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19. Characterization of a Gene Family Encoding SEA (Sea-urchin Sperm Protein, Enterokinase and Agrin)-Domain Proteins with Lectin-Like and Heme-Binding Properties from Schistosoma japonicum.

Author

Mbanefo, Evaristus Chibunna, Kikuchi, Mihoko, Huy, Nguyen Tien, Shuaibu, Mohammed Nasir, Cherif, Mahamoud Sama, Yu, Chuanxin, Wakao, Masahiro, Suda, Yasuo, and Hirayama, Kenji

Subjects
TETRAPYRROLES, PORPHYRINS, SCHISTOSOMA, SCHISTOSOMATIDAE, SCHISTOSOMA japonicum, SERINE proteinases
Abstract

Background: We previously identified a novel gene family dispersed in the genome of Schistosoma japonicum by retrotransposon-mediated gene duplication mechanism. Although many transcripts were identified, no homolog was readily identifiable from sequence information. Methodology/Principal Findings: Here, we utilized structural homology modeling and biochemical methods to identify remote homologs, and characterized the gene products as SEA (sea-urchin sperm protein, enterokinase and agrin)-domain containing proteins. A common extracellular domain in this family was structurally similar to SEA-domain. SEA-domain is primarily a structural domain, known to assist or regulate binding to glycans. Recombinant proteins from three members of this gene family specifically interacted with glycosaminoglycans with high affinity, with potential implication in ligand acquisition and immune evasion. Similar approach was used to identify a heme-binding site on the SEA-domain. The heme-binding mode showed heme molecule inserted into a hydrophobic pocket, with heme iron putatively coordinated to two histidine axial ligands. Heme-binding properties were confirmed using biochemical assays and UV-visible absorption spectroscopy, which showed high affinity heme-binding (KD = 1.605×10−6 M) and cognate spectroscopic attributes of hexa-coordinated heme iron. The native proteins were oligomers, antigenic, and are localized on adult worm teguments and gastrodermis; major host-parasite interfaces and site for heme detoxification and acquisition. Conclusions: The results suggest potential role, at least in the nucleation step of heme crystallization (hemozoin formation), and as receptors for heme uptake. Survival strategies exploited by parasites, including heme homeostasis mechanism in hemoparasites, are paramount for successful parasitism. Thus, assessing prospects for application in disease intervention is warranted. [ABSTRACT FROM AUTHOR]

Published
2014
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20. Protective Human Leucocyte Antigen Haplotype, HLADRB1* 01-B*14, against Chronic Chagas Disease in Bolivia.

Author

Del Puerto, Florencia, Nishizawa, Juan Eiki, Kikuchi, Mihoko, Roca, Yelin, Avilas, Cinthia, Gianella, Alberto, Lora, Javier, Velarde, Freddy Udalrico Gutierrez, Miura, Sachio, Komiya, Norihiro, Maemura, Koji, and Hirayama, Kenji

Subjects
TRYPANOSOMA cruzi, TRYPANOSOMA, LEUCOCYTES, LINKAGE disequilibrium, TROPICAL medicine, CHAGAS' disease
Abstract

Background: Chagas disease, caused by the flagellate parasite Trypanosoma cruzi affects 8-10 million people in Latin America. The mechanisms that underlie the development of complications of chronic Chagas disease, characterized primarily by pathology of the heart and digestive system, are not currently understood. To identify possible host genetic factors that may influence the clinical course of Chagas disease, Human Leucocyte Antigen (HLA) regional gene polymorphism was analyzed in patients presenting with differing clinical symptoms. Methodology: Two hundred and twenty nine chronic Chagas disease patients in Santa Cruz, Bolivia, were examined by serological tests, electrocardiogram (ECG), and Barium enema colon X-ray. 31.4% of the examinees showed ECG alterations, 15.7% megacolon and 58.1% showed neither of them. A further 62 seropositive megacolon patients who had undergone colonectomy due to acute abdomen were recruited. We analyzed their HLA genetic polymorphisms (HLA-A, HLA-B, MICA, MICB, DRB1 and TNF-alpha promoter region) mainly through Sequence based and LABType SSO typing test using LUMINEX Technology. Principal Findings: The frequencies of HLA-DRB1*01 and HLA-B*14:02 were significantly lower in patients suffering from megacolon as well as in those with ECG alteration and/or megacolon compared with a group of patients with indeterminate symptoms. The DRB1*0102, B*1402 and MICA*011 alleles were in strong Linkage Disequilibrium (LD), and the HLA-DRB1*01- B*14-MICA*011haplotype was associated with resistance against chronic Chagas disease. Conclusions: This is the first report of HLA haplotype association with resistance to chronic Chagas disease. [ABSTRACT FROM AUTHOR]

Published
2012
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21. Characterization of a Gene Family Encoding SEA (Sea-urchin Sperm Protein, Enterokinase and Agrin)-Domain Proteins with Lectin-Like and Heme-Binding Properties from Schistosoma japonicum.

Author

Mbanefo, Evaristus Chibunna, Kikuchi, Mihoko, Huy, Nguyen Tien, Shuaibu, Mohammed Nasir, Cherif, Mahamoud Sama, Yu, Chuanxin, Wakao, Masahiro, Suda, Yasuo, and Hirayama, Kenji

Subjects
*TETRAPYRROLES, *PORPHYRINS, *SCHISTOSOMA, *SCHISTOSOMATIDAE, *SCHISTOSOMA japonicum, *SERINE proteinases
Abstract

Background: We previously identified a novel gene family dispersed in the genome of Schistosoma japonicum by retrotransposon-mediated gene duplication mechanism. Although many transcripts were identified, no homolog was readily identifiable from sequence information. Methodology/Principal Findings: Here, we utilized structural homology modeling and biochemical methods to identify remote homologs, and characterized the gene products as SEA (sea-urchin sperm protein, enterokinase and agrin)-domain containing proteins. A common extracellular domain in this family was structurally similar to SEA-domain. SEA-domain is primarily a structural domain, known to assist or regulate binding to glycans. Recombinant proteins from three members of this gene family specifically interacted with glycosaminoglycans with high affinity, with potential implication in ligand acquisition and immune evasion. Similar approach was used to identify a heme-binding site on the SEA-domain. The heme-binding mode showed heme molecule inserted into a hydrophobic pocket, with heme iron putatively coordinated to two histidine axial ligands. Heme-binding properties were confirmed using biochemical assays and UV-visible absorption spectroscopy, which showed high affinity heme-binding (KD = 1.605×10−6 M) and cognate spectroscopic attributes of hexa-coordinated heme iron. The native proteins were oligomers, antigenic, and are localized on adult worm teguments and gastrodermis; major host-parasite interfaces and site for heme detoxification and acquisition. Conclusions: The results suggest potential role, at least in the nucleation step of heme crystallization (hemozoin formation), and as receptors for heme uptake. Survival strategies exploited by parasites, including heme homeostasis mechanism in hemoparasites, are paramount for successful parasitism. Thus, assessing prospects for application in disease intervention is warranted. [ABSTRACT FROM AUTHOR]

Published
2014
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22. Protective and enhancing HLA alleles, HLA-DRB1*0901 and HLA-A*24, for severe forms of dengue virus infection, dengue hemorrhagic fever and dengue shock syndrome.

Author

Nguyen TP, Kikuchi M, Vu TQ, Do QH, Tran TT, Vo DT, Ha MT, Vo VT, Cao TP, Tran VD, Oyama T, Morita K, Yasunami M, and Hirayama K

Subjects
Adolescent, Case-Control Studies, Child, Child, Preschool, Dengue Virus isolation & purification, Dengue Virus physiology, Female, HLA-A Antigens immunology, HLA-DR Antigens immunology, HLA-DRB1 Chains, Humans, Infant, Male, Severe Dengue virology, Genetic Predisposition to Disease, HLA-A Antigens genetics, HLA-DR Antigens genetics, Severe Dengue genetics, Severe Dengue immunology
Abstract

Background: Dengue virus (DV) infection is one of the most important mosquito-borne diseases in the tropics. Recently, the severe forms, dengue hemorrhagic fever (DHF) and dengue shock syndrome (DSS), have become the leading cause of death among children in Southern Vietnam. Protective and/or pathogenic T cell immunity is supposed to be important in the pathogenesis of DHF and DSS., Methodology/principal Findings: To identify HLA alleles controlling T cell immunity against dengue virus (DV), we performed a hospital-based case control study at Children's Hospital No.2, Ho Chi Minh City (HCMC), and Vinh Long Province Hospital (VL) in Southern Vietnam from 2002 to 2005. A total of 211 and 418 patients with DHF and DSS, respectively, diagnosed according to the World Health Organization (WHO) criteria, were analyzed for their characteristic HLA-A, -B and -DRB1 alleles. Four hundred fifty healthy children (250 from HCMC and 200 from VL) of the same Kinh ethnicity were also analyzed as population background. In HLA class I, frequency of the HLA-A*24 showed increased tendency in both DHF and DSS patients, which reproduced a previous study. The frequency of A*24 with histidine at codon 70 (A*2402/03/10), based on main anchor binding site specificity analysis in DSS and DHF patients, was significantly higher than that in the population background groups (HCMC 02-03 DSS: OR = 1.89, P = 0.008, DHF: OR = 1.75, P = 0.033; VL 02-03 DSS: OR = 1.70, P = 0.03, DHF: OR = 1.46, P = 0.38; VL 04-05 DSS: OR = 2.09, P = 0.0075, DHF: OR = 2.02, P = 0.038). In HLA class II, the HLA-DRB1*0901 frequency was significantly decreased in secondary infection of DSS in VL 04-05 (OR = 0.35, P = 0.0025, Pc = 0.03). Moreover, the frequency of HLA-DRB1*0901 in particular was significantly decreased in DSS when compared with DHF in DEN-2 infection (P = 0.02)., Conclusion: This study improves our understanding of the risk of HLA-class I for severe outcome of DV infection in the light of peptide anchor binding site and provides novel evidence that HLA-class II may control disease severity (DHF to DSS) in DV infection.

Published
2008
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