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Patient 1 who was a 43-year-old male was first referred to our institute because of an allergic reaction to metronidazole with oral mucosal erosions during his sixth treatment for amebic colitis. Graph: Fig 1 Macroscopic findings during colonoscopy.(A) Sporadic ulcerative lesions with edema were identified in the cecum of patient 1 before treatment. [[7]] These results raise the unresolved issue that monotherapy by a lumen-active agent can be inadequate treatment for asymptomatically infected patients with I E i . Successful treatment with paromomycin monotherapy due to metronidazole intolerance was microbiologically and endoscopically confirmed in 2 patients with mild symptoms of I E i . [Extracted from the article]