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The article discusses the newly completed whole genome sequence of Schistosoma haematobium, the leading cause of human schistosomiasis in Africa. It highlights the importance of this research in developing new tools to eliminate the disease, which affects over 90% of the roughly 200 million cases of schistosomiasis worldwide. The article also emphasizes the significant impact of urogenital schistosomiasis, caused by S. haematobium, on public health in Africa, including its association with AIDS and cancer. Despite its importance, research on S. haematobium has been limited compared to other schistosomes, but recent breakthroughs in animal models, in vitro systems, and omics technologies offer promising opportunities for further research and development. The article calls for international cooperation and increased support to advance S. haematobium research and address the disease burden in Africa. [Extracted from the article]