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On September 1, 2006, the World Health Organisation (WHO) announced that a deadly new strain of extensively drug-resistant tuberculosis (XDR-TB) had been detected in Tugela Ferry (Figure 1), a rural [...]

With more than 6 million HIV positive individuals--the highest of any country in the world--South Africa is the epicentre of the HIV/AIDS pandemic. In much of sub-Saharan Africa, especially South [...]

Summary Points * Time-sensitive access to unapproved experimental interventions should be permitted on humanitarian grounds when patients or communities are facing death or irreversible disease progression and no other efficacious diagnostic, preventive, or therapeutic alternative exists. * Regulatory deficits could stymie time-sensitive efforts to contain public health threats when no efficacious curative, therapeutic, or preventive interventions exist to counter the threat in question. * United States regulatory mechanisms may provide useful guidance from a regulatory perspective to policy makers grappling with how to adequately prepare for, or respond to, potential or emerging public health emergencies. * Access to unapproved experimental interventions should be underpinned by a robust monitoring and evaluation component that will inform product development and licensure. * A global-level rapid-response governance framework for the employment of unapproved interventions in humanitarian contexts should be established as a matter of urgency., The rampant spread of the Ebola virus in West Africa has prompted the World Health Organization (WHO) to declare the outbreak there a public health emergency of international concern [1]. [...]

The study in this week's issue of PLOS Medicine by Jewkes and colleagues on the prevalence of consensual male-male sexual activity and non-consensual male-on-male sexual violence, and their respective associations [...]

Human Health and Climate Change The 17th Conference of the Parties to the United Nations Convention on Climate Change (COP 17) concluded in December 2011, in Durban, South Africa, two [...]

The paper by Jones-Lopez et al. in this week's PLoS Medicine [1] (hereinafter ''the Uganda study'') illustrates the challenge of conducting research in resource-constrained settings. At the time the study [...]