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Your search keyword '"Shriver, Mark D."' showing total 11 results
Start Over Author "Shriver, Mark D." Journal plos genetics
11 results on '"Shriver, Mark D."'

1. Genome scans of facial features in East Africans and cross-population comparisons reveal novel associations

Author

Liu, Chenxing, primary, Lee, Myoung Keun, additional, Naqvi, Sahin, additional, Hoskens, Hanne, additional, Liu, Dongjing, additional, White, Julie D., additional, Indencleef, Karlijne, additional, Matthews, Harold, additional, Eller, Ryan J., additional, Li, Jiarui, additional, Mohammed, Jaaved, additional, Swigut, Tomek, additional, Richmond, Stephen, additional, Manyama, Mange, additional, Hallgrímsson, Benedikt, additional, Spritz, Richard A., additional, Feingold, Eleanor, additional, Marazita, Mary L., additional, Wysocka, Joanna, additional, Walsh, Susan, additional, Shriver, Mark D., additional, Claes, Peter, additional, Weinberg, Seth M., additional, and Shaffer, John R., additional

Published
2021
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2. 3D facial phenotyping by biometric sibling matching used in contemporary genomic methodologies

Author

Hoskens, Hanne, primary, Liu, Dongjing, additional, Naqvi, Sahin, additional, Lee, Myoung Keun, additional, Eller, Ryan J., additional, Indencleef, Karlijne, additional, White, Julie D., additional, Li, Jiarui, additional, Larmuseau, Maarten H. D., additional, Hens, Greet, additional, Wysocka, Joanna, additional, Walsh, Susan, additional, Richmond, Stephen, additional, Shriver, Mark D., additional, Shaffer, John R., additional, Peeters, Hilde, additional, Weinberg, Seth M., additional, and Claes, Peter, additional

Published
2021
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4. Genomewide Association Study of African Children Identifies Association of SCHIP1 and PDE8A with Facial Size and Shape

Author

Claes, Peter and Shriver, Mark D.

Subjects
Genotype, Imaging Techniques, Social Sciences, Nose, Research and Analysis Methods, Polymorphism, Single Nucleotide, White People, Diagnostic Medicine, Genome-Wide Association Studies, Genetics, Medicine and Health Sciences, Humans, Maxillofacial Development, Alleles, Genetic Association Studies, Forensics, Clinical Genetics, Morphometry, Biology and Life Sciences, Computational Biology, Genetic Variation, Human Genetics, Genomics, Genome Analysis, Clinical Laboratory Sciences, Phenotype, Genetic Loci, Face, Perspective, Genetics of Disease, Law and Legal Sciences, Anatomy, Head, Genome-Wide Association Study, Transcription Factors
Abstract

Numerous lines of evidence point to a genetic basis for facial morphology in humans, yet little is known about how specific genetic variants relate to the phenotypic expression of many common facial features. We conducted genome-wide association meta-analyses of 20 quantitative facial measurements derived from the 3D surface images of 3118 healthy individuals of European ancestry belonging to two US cohorts. Analyses were performed on just under one million genotyped SNPs (Illumina OmniExpress+Exome v1.2 array) imputed to the 1000 Genomes reference panel (Phase 3). We observed genome-wide significant associations (p5 x 10-8) for cranial base width at 14q21.1 and 20q12, intercanthal width at 1p13.3 and Xq13.2, nasal width at 20p11.22, nasal ala length at 14q11.2, and upper facial depth at 11q22.1. Several genes in the associated regions are known to play roles in craniofacial development or in syndromes affecting the face: MAFB, PAX9, MIPOL1, ALX3, HDAC8, and PAX1. We also tested genotype-phenotype associations reported in two previous genome-wide studies and found evidence of replication for nasal ala length and SNPs in CACNA2D3 and PRDM16. These results provide further evidence that common variants in regions harboring genes of known craniofacial function contribute to normal variation in human facial features. Improved understanding of the genes associated with facial morphology in healthy individuals can provide insights into the pathways and mechanisms controlling normal and abnormal facial morphogenesis.

Published
2016

8. Modeling 3D Facial Shape from DNA

Author

Claes, Peter, primary, Liberton, Denise K., additional, Daniels, Katleen, additional, Rosana, Kerri Matthes, additional, Quillen, Ellen E., additional, Pearson, Laurel N., additional, McEvoy, Brian, additional, Bauchet, Marc, additional, Zaidi, Arslan A., additional, Yao, Wei, additional, Tang, Hua, additional, Barsh, Gregory S., additional, Absher, Devin M., additional, Puts, David A., additional, Rocha, Jorge, additional, Beleza, Sandra, additional, Pereira, Rinaldo W., additional, Baynam, Gareth, additional, Suetens, Paul, additional, Vandermeulen, Dirk, additional, Wagner, Jennifer K., additional, Boster, James S., additional, and Shriver, Mark D., additional

Published
2014
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9. Genetic Architecture of Skin and Eye Color in an African-European Admixed Population

Author

Beleza, Sandra, primary, Johnson, Nicholas A., additional, Candille, Sophie I., additional, Absher, Devin M., additional, Coram, Marc A., additional, Lopes, Jailson, additional, Campos, Joana, additional, Araújo, Isabel Inês, additional, Anderson, Tovi M., additional, Vilhjálmsson, Bjarni J., additional, Nordborg, Magnus, additional, Correia e Silva, António, additional, Shriver, Mark D., additional, Rocha, Jorge, additional, Barsh, Gregory S., additional, and Tang, Hua, additional

Published
2013
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11. Identifying Signatures of Natural Selection in Tibetan and Andean Populations Using Dense Genome Scan Data

Author

Bigham, Abigail, primary, Bauchet, Marc, additional, Pinto, Dalila, additional, Mao, Xianyun, additional, Akey, Joshua M., additional, Mei, Rui, additional, Scherer, Stephen W., additional, Julian, Colleen G., additional, Wilson, Megan J., additional, López Herráez, David, additional, Brutsaert, Tom, additional, Parra, Esteban J., additional, Moore, Lorna G., additional, and Shriver, Mark D., additional

Published
2010
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