Search

Your search keyword '"Kibriya, Muhammad G."' showing total 6 results
Start Over Author "Kibriya, Muhammad G." Journal plos genetics
6 results on '"Kibriya, Muhammad G."'

1. Sequencing-based fine-mapping and in silico functional characterization of the 10q24.32 arsenic metabolism efficiency locus across multiple arsenic-exposed populations

Author

Chernoff, Meytal Batya, primary, Delgado, Dayana, additional, Tong, Lin, additional, Chen, Lin, additional, Oliva, Meritxell, additional, Tamayo, Lizeth I., additional, Best, Lyle G., additional, Cole, Shelley, additional, Jasmine, Farzana, additional, Kibriya, Muhammad G., additional, Nelson, Heather, additional, Huang, Lei, additional, Haack, Karin, additional, Kent, Jack, additional, Umans, Jason G., additional, Graziano, Joseph, additional, Navas-Acien, Ana, additional, Karagas, Margaret R., additional, Ahsan, Habib, additional, and Pierce, Brandon L., additional

Published
2023
Full Text
View/download PDF

2. Correction: A missense variant in FTCD is associated with arsenic metabolism and toxicity phenotypes in Bangladesh

Author

Pierce, Brandon L., primary, Tong, Lin, additional, Dean, Samantha, additional, Argos, Maria, additional, Jasmine, Farzana, additional, Rakibuz-Zaman, Muhammad, additional, Sarwar, Golam, additional, Islam, Md. Tariqul, additional, Shahriar, Hasan, additional, Islam, Tariqul, additional, Rahman, Mahfuzar, additional, Yunus, Md., additional, Lynch, Vincent J., additional, Oglesbee, Devin, additional, Graziano, Joseph H., additional, Kibriya, Muhammad G., additional, Gamble, Mary V., additional, and Ahsan, Habibul, additional

Published
2019
Full Text
View/download PDF

3. A missense variant in FTCD is associated with arsenic metabolism and toxicity phenotypes in Bangladesh

Author

Pierce, Brandon L., primary, Tong, Lin, additional, Dean, Samantha, additional, Argos, Maria, additional, Jasmine, Farzana, additional, Rakibuz-Zaman, Muhammad, additional, Sarwar, Golam, additional, Islam, Md. Tariqul, additional, Shahriar, Hasan, additional, Islam, Tariqul, additional, Rahman, Mahfuzar, additional, Yunus, Md., additional, Lynch, Vincent J., additional, Oglesbee, Devin, additional, Graziano, Joseph H., additional, Kibriya, Muhammad G., additional, Gamble, Mary V., additional, and Ahsan, Habibul, additional

Published
2019
Full Text
View/download PDF

4. A missense variant in FTCD affects arsenic metabolism and toxicity phenotypes in Bangladesh.

Author

Pierce, Brandon L., Tong, Lin, Dean, Samantha, Argos, Maria, Jasmine, Farzana, Rakibuz-Zaman, Muhammad, Sarwar, Golam, Islam, Md. Tariqul, Shahriar, Hasan, Islam, Tariqul, Rahman, Mahfuzar, Yunus, Md., Lynch, Vincent J., Oglesbee, Devin, Graziano, Joseph H., Kibriya, Muhammad G., Gamble, Mary V., and Ahsan, Habibul

Subjects
ARSENIC poisoning, ARSENIC metabolism, PHYSIOLOGICAL effects of arsenic, CARCINOGENS, ARSENIC in water, MISSENSE mutation
Abstract

Inorganic arsenic (iAs) is a carcinogen, and exposure to iAs via food and water is a global public health problem. iAs-contaminated drinking water alone affects >100 million people worldwide, including ~50 million in Bangladesh. Once absorbed into the blood stream, most iAs is converted to mono-methylated (MMA) and then di-methylated (DMA) forms, facilitating excretion in urine. Arsenic metabolism efficiency varies among individuals, in part due to genetic variation near AS3MT (arsenite methyltransferase; 10q24.32). To identify additional arsenic metabolism loci, we measured protein-coding variants across the human exome for 1,660 Bangladeshi individuals participating in the Health Effects of Arsenic Longitudinal Study (HEALS). Among the 19,992 coding variants analyzed exome-wide, the minor allele (A) of rs61735836 (p.Val101Met) in exon 3 of FTCD (formiminotransferase cyclodeaminase) was associated with increased urinary iAs% (P = 8x10-13), increased MMA% (P = 2x10-16) and decreased DMA% (P = 6x10-23). Among 2,401 individuals with arsenic-induced skin lesions (an indicator of arsenic toxicity and cancer risk) and 2,472 controls, carrying the low-efficiency A allele (frequency = 7%) was associated with increased skin lesion risk (odds ratio = 1.35; P = 1x10-5). rs61735836 is in weak linkage disequilibrium with all nearby variants. The high-efficiency/major allele (G/Valine) is human-specific and eliminates a start codon at the first 5´-proximal Kozak sequence in FTCD, suggesting selection against an alternative translation start site. FTCD is critical for catabolism of histidine, a process that generates one-carbon units that can enter the one-carbon/folate cycle, which provides methyl groups for arsenic metabolism. In our study population, FTCD and AS3MT SNPs together explain ~10% of the variation in DMA% and support a causal effect of arsenic metabolism efficiency on arsenic toxicity (i.e., skin lesions). In summary, this work identifies a coding variant in FTCD associated with arsenic metabolism efficiency, providing new evidence supporting the established link between one-carbon/folate metabolism and arsenic toxicity. [ABSTRACT FROM AUTHOR]

Published
2019
Full Text
View/download PDF

5. Mediation Analysis Demonstrates That Trans-eQTLs Are Often Explained by Cis-Mediation: A Genome-Wide Analysis among 1,800 South Asians

Author

Pierce, Brandon L., primary, Tong, Lin, additional, Chen, Lin S., additional, Rahaman, Ronald, additional, Argos, Maria, additional, Jasmine, Farzana, additional, Roy, Shantanu, additional, Paul-Brutus, Rachelle, additional, Westra, Harm-Jan, additional, Franke, Lude, additional, Esko, Tonu, additional, Zaman, Rakibuz, additional, Islam, Tariqul, additional, Rahman, Mahfuzar, additional, Baron, John A., additional, Kibriya, Muhammad G., additional, and Ahsan, Habibul, additional

Published
2014
Full Text
View/download PDF

6. Genome-Wide Association Study Identifies Chromosome 10q24.32 Variants Associated with Arsenic Metabolism and Toxicity Phenotypes in Bangladesh

Author

Pierce, Brandon L., primary, Kibriya, Muhammad G., additional, Tong, Lin, additional, Jasmine, Farzana, additional, Argos, Maria, additional, Roy, Shantanu, additional, Paul-Brutus, Rachelle, additional, Rahaman, Ronald, additional, Rakibuz-Zaman, Muhammad, additional, Parvez, Faruque, additional, Ahmed, Alauddin, additional, Quasem, Iftekhar, additional, Hore, Samar K., additional, Alam, Shafiul, additional, Islam, Tariqul, additional, Slavkovich, Vesna, additional, Gamble, Mary V., additional, Yunus, Md, additional, Rahman, Mahfuzar, additional, Baron, John A., additional, Graziano, Joseph H., additional, and Ahsan, Habibul, additional

Published
2012
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results