1. Predictors of high on-clopidogrel platelet reactivity in patients with acute coronary syndrome
- Author
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Andrea Kovacs, Nóra Zsuzsa Kiss, Sarolta Leé, Zsófia Horváth, Róbert Gábor Kiss, Istvan Hizoh, and Emese Toth-Zsamboki
- Subjects
Blood Platelets ,medicine.medical_specialty ,Acute coronary syndrome ,Ticlopidine ,Platelet Aggregation ,medicine.medical_treatment ,030204 cardiovascular system & hematology ,Coronary Angiography ,03 medical and health sciences ,Percutaneous Coronary Intervention ,0302 clinical medicine ,Risk Factors ,Internal medicine ,medicine ,Platelet ,Prospective Studies ,030212 general & internal medicine ,Acute Coronary Syndrome ,Prospective cohort study ,Platelet Count ,business.industry ,Smoking ,Area under the curve ,Percutaneous coronary intervention ,Thrombosis ,Hematology ,General Medicine ,Platelet Activation ,Clopidogrel ,medicine.disease ,Surgery ,C-Reactive Protein ,Logistic Models ,Treatment Outcome ,Area Under Curve ,Cohort ,Cardiology ,business ,Platelet Aggregation Inhibitors ,medicine.drug - Abstract
High on-clopidogrel platelet reactivity (HPR) is a predictor of ischemic events after percutaneous coronary intervention. We conducted a prospective cohort study to identify variables related to HPR in acute coronary syndrome patients who are at high thrombotic risk. We enrolled 463 patients undergoing urgent coronary angiography. Platelet reactivity was measured 12-36 hours after 600 mg clopidogrel loading with multiple electrode aggregometry (Multiplate® analyzer, Roche, Basel, Switzerland, 6.4 µM ADP). HPR was defined by the consensus cut-off area under the curve >46 U. The rate of HPR was 16.0%. We analyzed simple clinical and laboratory parameters with backward multivariate logistic regression and identified the following predictors of HPR: platelet count (per G/L, OR: 1.0073, 95% CI: 1.0035-1.0112, p = 0.0002), CRP level (per mg/L, OR: 1.0077, 95% CI: 1.0016-1.01372, p = 0.01), and active smoking (OR: 0.51, 95% CI: 0.29-0.89, p = 0.02). We developed and internally validated a risk prediction model demonstrating moderate discriminative capacity (area-under-the-receiver operating characteristic curve = 0.67). In conclusion, we found a relatively low rate of high on-clopidogrel platelet reactivity (16.0%) even in an acute patient cohort. HPR measured by Multiplate was associated with high platelet count and CRP level on admission and was inversely related to active smoking. The model with rapidly available simple parameters might help to identify individuals at risk for HPR in the acute setting.
- Published
- 2015