1. Anti-scratching behavioral effect of the essential oil and phytol isolated from Artemisia princeps Pamp. in mice
- Author
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Kwon-Ryeol Ryu, Jong-Youl Choi, Suna Chung, and Dong-Hyun Kim
- Subjects
Pharmaceutical Science ,Pharmacology ,Pharmacognosy ,Asteraceae ,Analytical Chemistry ,law.invention ,chemistry.chemical_compound ,Phytol ,Mice ,law ,In vivo ,Drug Discovery ,Oils, Volatile ,Animals ,Plant Oils ,Essential oil ,Mice, Inbred BALB C ,Mice, Inbred ICR ,integumentary system ,Traditional medicine ,biology ,Tumor Necrosis Factor-alpha ,Pruritus ,Organic Chemistry ,NF-kappa B ,Antipruritics ,biology.organism_classification ,Enzyme Activation ,Transcription Factor AP-1 ,Complementary and alternative medicine ,chemistry ,Molecular Medicine ,Artemisia ,Tumor necrosis factor alpha ,Interleukin-4 ,Diterpene ,Histamine - Abstract
The anti-scratching behavioral effect of the essential oil and phytol isolated from Artemisia princeps Pamp. (AP, family Asteraceae), which is widely used in traditional medicine for inflammatory diseases, was investigated IN VIVO. Treatment of mice with AP essential oil (APEO) and phytol inhibited histamine- and compound 48/80-induced scratching behaviors. The anti-scratching behavioral effects of APEO and phytol are in proportion to their vascular permeability-inhibitory effects. These agents also inhibited the level of allergic cytokines, IL-4, and TNF- α, and the activation of transcription factors, NF- κB and c-jun (AP-1), in histamine-treated skin tissues. Based on these results, APEO and phytol may improve scratching behavior in skin by inhibiting the expression of allergic cytokines via the regulation of NF- κB and AP-1 activation.
- Published
- 2010