1. Predictive value of blood measurement of Complement System proteins and metabolic components for early detection of obstetric complications linked to poor placental function
- Author
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Mariana Cora, Valentina López, Sebastián Rosano, Claudio Rodríguez-Camejo, Valentina Zubiaurre, Ana Hernández, Valentina Colistro, Paula Arbildi, Leonardo Sosa, Nahir Correa, and Cecilia Sóñora
- Subjects
Adult ,0301 basic medicine ,Obstetric risk ,Physiology ,Early detection ,Young Adult ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Blood concentration ,Predictive Value of Tests ,Pregnancy ,Humans ,Medicine ,030219 obstetrics & reproductive medicine ,biology ,business.industry ,Cholesterol ,C-reactive protein ,Obstetrics and Gynecology ,Complement System Proteins ,Predictive value ,Complement system ,Pregnancy Complications ,030104 developmental biology ,Reproductive Medicine ,chemistry ,Case-Control Studies ,Metabolic markers ,biology.protein ,Female ,business ,Developmental Biology - Abstract
Preeclampsia-eclampsia syndrome (PES) is associated with severe obstetric complications and there are no efficient methods available for an early detection. We studied blood concentration of some immunological and metabolic markers in association with obstetric outcome in healthy pregnant women and patients with obstetric risk factors, by ELISA and biochemical tests. Patients with complications showed higher levels of CRP and C4 positively correlated with Triglycerides and Cholesterol concentrations. Our results provide evidence that Immunological and metabolic alterations contribute to obstetric complications and that biomarkers linked to these alterations could be useful for an early detection of these problems.
- Published
- 2020
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